| Interacting proteins: P49795 and O14908 |
Pubmed |
SVM Score :0.91607976 |
| Since GIPC exclusively interacted with GAIP and selectively with subsets of GPCR , this mechanism may serve to sort GPCR signaling in cells that usually express a large repertoire of GPCRs , G proteins , and RGS . . 0.91607976^^^ |
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| Interacting proteins: P49795 and O14908 |
Pubmed |
SVM Score :0.0 |
| GIPC , a PDZ domain containing protein , interacts specifically with the C terminus of RGS GAIP . ^^^ We have identified a mammalian protein called GIPC ( for GAIP interacting protein , C terminus ) , which has a central PDZ domain and a C terminal acyl carrier protein ( ACP ) domain . ^^^ The PDZ domain of GIPC specifically interacts with RGS GAIP , a GTPase activating protein ( GAP ) for Galphai subunits recently localized on clathrin coated vesicles . ^^^ Analysis of deletion mutants indicated that the PDZ domain of GIPC specifically interacts with the C terminus of GAIP ( 11 amino acids ) in the yeast two hybrid system and glutathione S transferase ( GST ) GIPC pull down assays , but GIPC does not interact with other members of the RGS ( regulators of G protein signaling ) family tested . ^^^ The location of GIPC together with its binding to GAIP suggest that GAIP and GIPC may be components of a G protein coupled signaling complex involved in the regulation of vesicular trafficking . ^^^ |
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| Interacting proteins: P49795 and O14908 |
Pubmed |
SVM Score :0.0 |
| SEMCAP 1 has recently also been identified as GIPC , by virtue of its interaction with the RGS protein GAIP in vitro ( De Vries , L . , Lou , X . , Zhao , G . , Zheng , B . , and Farquhar , M . ^^^ Expression studies support the notion that SEMCAP 1 ( GIPC ) interacts with M SemF , but not GAIP , in brain . ^^^ Lung SEMCAP 2 and SEMCAP 1 ( GIPC ) are potential partners for both GAIP and M SemF . ^^^ |
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| Interacting proteins: P49795 and O14908 |
Pubmed |
SVM Score :0.0 |
| GIPC and GAIP form a complex with TrkA : a putative link between G protein and receptor tyrosine kinase pathways . ^^^ The PDZ domain of GIPC also interacts with GAIP , an RGS ( regulators of G protein signaling ) protein . ^^^ GIPC and GAIP are components of a G protein coupled signaling complex thought to be involved in vesicular trafficking . ^^^ In transfected HEK 293T cells GIPC , GAIP , and TrkA form a coprecipitable protein complex . ^^^ Both TrkA and GAIP bind to the PDZ domain of GIPC , but their binding sites within the PDZ domain are different . ^^^ |
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| Interacting proteins: P49795 and O14908 |
Pubmed |
SVM Score :0.0 |
| GAIP , GIPC and Galphai 3 are concentrated in endocytic compartments of proximal tubule cells : putative role in regulating megalin ' s function . ^^^ By immunofluorescence GIPC and GAIP , components of G protein mediated signaling pathways , are also concentrated in the brush border region of PTE and are present in megalin expressing cell lines . ^^^ GAIP is found by immunoelectron microscopy in CCPs , and GIPC is found in CCPs and apical tubules of endocytic compartments in the renal brush border . ^^^ The concentration of Galphai 3 , GIPC , and GAIP with megalin in endocytic compartments of the proximal tubule , where extensive endocytosis occurs , and the interaction between GIPC and the cytoplasmic tail of megalin suggest a model whereby G protein mediated signaling may regulate megalin ' s endocytic function and / or trafficking . . ^^^ |
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| Interacting proteins: P49795 and O14908 |
Pubmed |
SVM Score :0.0 |
| By screening a rat brain cDNA library using the yeast two hybrid system with the C terminus domain of the dopamine D ( 3 ) receptor ( D ( 3 ) R ) as bait , we characterized a new interaction with the PDZ domain containing protein , GIPC ( GAIP interacting protein , C terminus ) . ^^^ |
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| Interacting proteins: P49795 and O14908 |
Pubmed |
SVM Score :0.0 |
| Knockdown of GAIP and of the GAIP interacting protein C terminus ( GIPC ) led to changes in agonist effects at mu but not at delta receptors . ^^^ |
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| Interacting proteins: P49795 and O14908 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49795 and O14908 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49795 and O14908 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49795 and O14908 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49795 and O14908 |
Pubmed |
SVM Score :0.0 |
| NA |
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