| We report here that the intracellular domain of the Xenopus IGF 1 receptor is capable of binding to the Xenopus homolog of mammalian GIPC , a PDZ domain containing protein previously identified as a binding partner of G ( 1 ) specific GAP ( RGS GAIP ) . ^^^ This represents the first demonstration that GIPC 10 RGS GAIP complex acts positively in IGF 1 receptor signal transduction . . ^^^ GIPC participates in G protein signaling downstream of insulin like growth factor 1 receptor . ^^^ |