| Furthermore , knocking down of RGS GAIP interacting protein C terminus ( GIPC ) in zebrafish , which is associated with C terminal domain of NRP 1 , exhibits similar vasculature phenotypes to those from NRP 1 null . ^^^ Specific and effective silencing of GIPC in vascular endothelium results in inhibition of NRP 1 mediated migration . ^^^ Taken together , our data suggest a novel role of GIPC in angiogenesis and vessel formation and also support our hypothesis that NRP 1 can facilitate downstream signaling to promote angiogenesis through GIPC . . ^^^ |