Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
The protein microarray approach revealed radiation induced up regulation of apoptotic regulators including p 53 , DNA fragmentation factor 40 / caspase activated DNase , DNA fragmentation factor 45 / inhibitor of caspase activated DNase , tumor necrosis factor related apoptosis inducing ligand , death receptor 5 , decoy receptor 2 , FLICE like inhibitory protein , signal transducers and activators of transcription 1alpha , and uncoupling protein 2 , among others . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
The RT PCR and Western blotting results demonstrated that the levels of both mRNA and protein for death receptor 4 , death receptor 5 and decoy receptor 2 remained unchanged in response to etoposide , indicating that the synergistic effect of TRAIL and etoposide is not a result of increasing the expression for TRAIL receptors , but rather is associated with amplification of the mitochondrial signal pathway . . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
Although chemotherapy treatment did not modulate mRNA or cell surface expression of the TRAIL receptors death receptor 4 , death receptor 5 , decoy receptor 1 , or decoy receptor 2 , it was found to down regulate expression of the caspase 8 inhibitor , c FLIP . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
TRAIL R 4 encodes a 386 amino acid protein with an extracellular domain showing 58 % 70 % identity to those of TRAIL R 1 , TRAIL R 2 , and TRAIL R 3 . ^^^ The signaling capacity of TRAIL R 4 is similar to that of TRAIL R 1 and TRAIL R 2 with respect to NF kappaB activation , but differs in its inability to induce apoptosis . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
Past studies have shown that apoptosis mediated by TNF related apoptosis inducing ligand ( TRAIL ) is regulated by the expression of two death receptors [ TRAIL receptor 1 ( TRAIL R 1 ) and TRAIL R 2 ] and two decoy receptors ( TRAIL R 3 and TRAIL R 4 ) that inhibit apoptosis . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) related apoptosis inducing ligand ( TRAIL ) is a member of the TNF family that interacts with several receptors , including TRAIL R 1 , TRAIL R 2 , and TRAIL R 4 . ^^^ Here we show that TRAIL R 1 , TRAIL R 2 , and TRAIL R 4 induced NF kappaB activation are mediated by a TRAF 2 NIK IkappaB kinase alpha / beta signaling cascade but is MEKK 1 independent . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
The ( auto ) antigen specific T cells were also resistant to specific TRAIL R1 / TRAIL R 2 directed induction of apoptosis , indicating that coexpression of the truncated TRAIL R 3 and TRAIL R 4 in these T cells is not responsible for the observed resistance . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
It is regulated by 2 death receptors , TRAIL receptor 1 ( TRAIL R 1 ) and TRAIL R 2 , and 2 decoy receptors , TRAIL R 3 and TRAIL R 4 . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
TRAIL sensitivity of the PNET cell lines was correlated with mRNA expression levels of TRAIL , its agonistic ( TRAIL R 1 , TRAIL R 2 ) and antagonistic ( TRAIL R 3 , TRAIL R 4 ) receptors , cellular FLICE like inhibitory protein ( cFLIP ) , caspase 3 and caspase 8 . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
Drug exposure resulted in enhanced TRAIL R 2 expression , but decreased TRAIL R 4 expression in U87MG cells . ^^^ Ectopic expression of dominant negative p 53 ( V135A ) abrogated the drug induced changes in TRAIL R 2 and TRAIL R 4 expression , but had no effect on synergy . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
Tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) , a member of the tumor necrosis factor ( TNF ) family , binds to several cell surface receptors with distinct functions ( agonistic receptors 1 and 2 [ TRAIL R 1 , TRAIL R 2 ] ; decoy receptors 3 and 4 [ TRAIL R 3 , TRAIL R 4 ] ) . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
RESULTS : Normal colonic epithelial cells express TRAIL , TRAIL R 1 , TRAIL R 2 , and TRAIL R 4 . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
It is regulated by 2 death receptors , TRAIL receptor 1 ( TRAIL R 1 ) and TRAIL R 2 and 2 decoy receptors , TRAIL R 3 and TRAIL R 4 . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
RESULTS : For RPE cells derived directly from the eye , we detected mRNAs of Trail R 2 , Trail R 3 , TRAIL , and APO 3 L , but not Trail R 1 , Trail R 4 , and TRAMP . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
Low levels of the death inducing TRAIL receptors , TRAIL R 1 and TRAIL R 2 but not the putative ' decoy ' receptors , TRAIL R 3 and TRAIL R 4 , were expressed on the surface of B CLL cells . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
TRAIL interacts with four receptors : two signalling receptors ( TRAIL R 1 and TRAIL R 2 ) and two decoy receptors ( TRAIL R 3 and TRAIL R 4 ) . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
TRAIL receptor ( TRAIL R ) 1 and TRAIL R 2 , but not TRAIL R 3 and TRAIL R 4 , mediate apoptosis . ^^^ RESULTS : In normal colon mucosa , TRAIL and TRAIL R 2 were expressed mostly in the surface epithelium , whereas TRAIL R 1 and TRAIL R 4 were detected all along the crypt axis . ^^^ TRAIL , TRAIL R 2 , TRAIL R 3 , and TRAIL R 4 expression did not correlate statistically with disease free survival ( multivariate analysis : P = 0 . 54 , P = 0 . 67 , P = 0 . 45 , and P = 0 . 69 , respectively ) , but TRAIL R 1 expression was significantly associated with disease free survival in colon cancer ( multivariate analysis : P = 0 . 003 ) . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
The SK N MC neuroblastoma cell line , which expresses surface tumour necrosis factor related apoptosis inducing ligand ( TRAIL ) receptors TRAIL R 2 and TRAIL R 4 , was used as a model system to examine the effect of TRAIL on key intracellular pathways involved in the control of neuronal cell survival and apoptosis . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
In normal pancreas , a minor subset of acinar cells coexpressed TRAIL R 2 and TRAIL R 4 , whereas ductular epithelium and interstitial fibroblast like cells ( FLC ) expressed TRAIL R 4 . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
TRAIL is unusual as compared to the other cytokines of this family , as it interacts with a complex system of receptors consisting of two pro apoptotic death receptors ( TRAIL R 1 and TRAIL R 2 ) and three decoy receptors ( TRAIL R 3 , TRAIL R 4 and osteoprotegerin ) . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
Five distinct receptors have been described for TRAIL : TRAIL R 1 ( DR 4 ) , TRAIL R 2 ( DR 5 , TRICK ) , TRAIL R 3 ( TRID , DcR 1 ) , TRAIL R 4 ( TRUNDD , DcR 2 ) , and osteoprotegerin . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
The `` decoy receptors ' ' TRAIL R 3 ( TR 3 ) and TRAIL R 4 ( TR 4 ) were believed to negatively regulate TRAIL induced cytotoxicity by competing for ligand binding with TRAIL R 1 ( TR 1 ) and TRAIL R 2 ( TR 2 ) . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
Tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) induces apoptosis in melanoma by interaction with death receptors TRAIL R 1 ( DR 4 ) or TRAIL R 2 ( DR 5 ) on melanoma cells or resists apoptosis by interaction with decoy receptors TRAIL R 3 ( DcR 1 ) or TRAIL R 4 ( DcR 2 ) . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
Susceptibility of the prostate cancer cell types to Apo 2L / TRAIL induced apoptosis did not appear to correlate with the levels of the Apo 2L / TRAIL receptors death receptor ( DR ) 4 ( TRAIL receptor 1 ) or DR 5 ( TRAIL receptor 2 ) , decoy receptor ( DcR ) 1 and DcR 2 , Flame 1 , or the inhibitors of apoptosis proteins family of proteins . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
The DcR 2 gene mapped to human chromosome 8p21 , as did the genes encoding DR 4 , DR 5 and DcR 1 . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
APO2L ( TRAIL ) is a novel CD95L ( Fas / APO 1 L ) homologous cytotoxic cytokine that interacts with various receptors which transmit ( DR 4 , DR 5 ) or inhibit ( DcR 1 , DcR 2 ) an apoptotic signal . ^^^ Here , we report that human glioma cell lines preferentially express mRNAs for agonistic death receptors DR 4 ( 8 / 12 ) and DR 5 ( 11 / 12 ) rather than the death inhibitory decoy receptors DcR 1 ( 4 / 12 ) and DcR 2 ( 2 / 12 ) . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
AP 02 ligand ( APO2L ) is a CD 95 ligand ( CD95L ) related cytokine of the tumor necrosis factor family that interacts with agonistic ( DR 4 , DR 5 ) and antagonistic ( DcR 1 , DcR 2 ) receptors . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
Although all four lines contained mRNA encoding the apoptosis inducing DR 5 receptor , only trophoblast cells contained mRNA encoding the DcR 1 decoy receptor and only macrophages contained DcR 2 decoy receptor transcripts . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
The third receptor , called DcR 2 , is structurally similar to DR 4 and DR 5 but has a truncated cytoplasmic death domain and does not transmit a death signal . ^^^ Transfection experiments indicate that DcR 1 and DcR 2 act as decoys that prevent Apo2L from inducing apoptosis through DR 4 and DR 5 . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
This protective effect of TRUNDD was not dependent on the presence of TRAIL , and overexpression of TRUNDD did not alter the protein levels of either p 53 or KILLER / DR 5 . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
Treatment of human leukemic cells with etoposide , Ara C , or doxorubicin increased DR 5 but not DR 4 , Fas , DcR 1 , DcR 2 , Fas ligand , or Apo 2L levels . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
TRAIL triggers apoptosis by binding to its two proapoptotic receptors DR 4 and DR 5 , a process which is negatively regulated by binding of TRAIL to its two decoy receptors TRID and TRUNDD . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
TRAIL binds to death receptors ( DRs ) DR 4 , DR 5 , DcR 1 , and DcR 2 . ^^^ Either DR 4 or DR 5 can induce apoptosis , whereas DcR 1 and DcR 2 are considered inhibitory receptors . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
Apo2L / TRAIL also binds to `` decoy ' ' receptors ( DcR 1 and DcR 2 ) that can antagonize its interaction with DR 4 and DR 5 . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
Four related receptors bind TRAIL , two death receptors ( DR 4 and DR 5 ) that signal apoptosis and two decoy receptors ( DcR 1 and DcR 2 ) that act as dominant negative inhibitors of TRAIL mediated apoptosis . ^^^ Our results indicate that overexpression of cRel or activation of endogenous Rel / NF kappaB factors by TNFalpha in HeLa cells up regulates DcR 1 without changing the expression of DcR 2 , DR 4 , and DR 5 and makes cells resistant against TRAIL induced apoptosis . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
Although three other TRAIL receptors DR 5 , DcR 1 , and DcR 2 are induced by DNA damage and are regulated by the wild type p 53 tumor suppressor , it was not known whether these factors also affect DR 4 expression . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
TRAIL ( tumor necrosis factor ( TNF ) related apoptosis inducing ligand ) , a recently identified member of the growing TNF superfamily , binds to its cognate `` death ' ' receptors DR 4 and DR 5 as well as `` decoy ' ' receptors DcR 1 and DcR 2 . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
Platelets do not express the death receptors Fas , DR 4 and DR 5 on their plasma membrane , while the expression of the decoy receptor DcR 2 increases progressively during platelet storage . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
AZT and IFN alpha mediated apoptosis in PEL was blocked by stable overexpression of dominant negative Fas Associated Death Domain ( FADD ) , decoy receptor 2 ( DcR 2 ) , soluble TRAIL receptor fusion proteins ( DR 4 and DR 5 ) and thymidine . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
METHODS : We investigated the presence and functional status of TRAIL and its receptors , DR 4 , DR 5 , and DcR 2 on tumor as well as tumor infiltrating lymphocytes ( TIL ) in primary ( n=37 ) , and metastatic gastric carcinoma from malignant ascites ( n=37 ) by a flow cytometry . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
TRAIL can bind to four different receptors , two pro apoptotic death receptors ( DRs ) , DR 4 and DR 5 , and two antiapoptotic decoy receptors ( DcRs ) , DcR 1 and DcR 2 . ^^^ We studied the tumor specific down regulation of the TRAIL receptors DcR 1 and DcR 2 , as well as DR 4 and DR 5 , in a group of pediatric tumor cell lines [ nine neuroblastoma and three peripheral primitive neuro ectodermal tumors ( PNETs ) ] and three cell lines from adult tumors . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
Western analysis demonstrated that increased apoptotic response of PC3AR cells may be due to differential response of death receptors DR 4 , DR 5 and decoy receptors DcR 1 and DcR 2 . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
TRAIL binds four different membrane bound receptors : DR 4 , DR 5 , DcR 1 , and DcR 2 . ^^^ We demonstrated by reverse transcriptase polymerase chain reaction and flow cytometry that , in vitro , normal human articular chondrocytes express the receptors mediating apoptosis ( DR 4 and DR 5 ) and one of the decoy receptors ( DcR 2 ) . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
Reverse transcriptase polymerase chain reaction ( RT PCR ) was applied to assay mRNA expression of TRAIl ( the TNF related apoptosis inducing ligand ) receptors ( DR 5 , DcR 1 , and DcR 2 ) in 3 cases of normal ovarian tissues , 6 cases of ovarian benign tumors , and 16 cases of ovarian cancers . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
We have investigated the expression , in human osteoblast like cells ( NHBC ) , of Apo2L / TRAIL and the known Apo2L / TRAIL death receptors , DR 4 and DR 5 , and the Apo2L / TRAIL decoy receptors , DcR 1 , DcR 2 , and osteoprotegerin ( OPG ) . ^^^ DR 5 and DcR 2 were present in the cell membrane and cytoplasm and DcR 1 was confined to the nucleus . ^^^ In NHBC , we observed strong associations between the levels of mRNA corresponding to the pro apoptotic molecules , Apo2L / TRAIL , DR 4 , and DR 5 , and those corresponding to pro survival molecules , DcR 1 , DcR 2 , OPG , and FLIP , suggesting that the balance between pro survival and pro apoptotic molecules is a mechanism by which NHBC can resist Apo2L / TRAIL mediated apoptosis . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
This was confirmed by quantitative immunocytochemical image analysis of BAL eosinophils and alveolar macrophages , which demonstrated that expression levels of TRAIL and DcR 2 increased , whereas expression levels of the TRAIL Rs DR 4 and DR 5 decreased in asthmatic subjects after SAC . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
Apo2L / TRAIL receptors ( DR 4 , DR 5 , DcR 1 , and DcR 2 ) , c FLIP , Bcl 2 , and other IAP members ( c IAP 1 and c IAP 2 ) were marginally affected at later times in the cells sensitized by Act D . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
TRAIL receptor mRNAs ( DR 4 , DR 5 , and DcR 2 ) were induced by doxorubicin but these changes were not reflected at the protein level . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
AIM : To observe the localization of TRAIL / TRAIR ( DR 4 , DR 5 , DcR 1 , DcR 2 ) in the fetal pancreas . ^^^ There were a few DcR 1 and DcR 2 positive cells whereas there were no immunoreactive cells of DR 4 and DR 5 in the pancreas islets . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
To determine the molecular mechanisms involved in the enhanced apoptosis , we examined the expression of two TRAIL death receptors ( DR 4 and DR 5 ) and two TRAIL decoy receptors ( DcR 1 and DcR 2 ) . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
Preparation and characterization of a set of monoclonal antibodies to TRAIL and TRAIL receptors DR 4 , DR 5 , DcR 1 , and DcR 2 . ^^^ Among TRAIL receptors , death receptor 4 ( DR 4 ) and DR 5 containing death domain ( DD ) in their cytoplasmic region mediate apoptosis signaling upon TRAIL binding , while decoy receptor 1 ( DcR 1 ) and DcR 2 with a truncated or non functional DD play `` decoy ' ' role . ^^^ In this study , we raised hybridomas secreting monoclonal antibodies against TRAIL ( FMU1 . 1 , 1 . 2 , 1 . 3 ) , DR 4 ( FMU1 . 4 ) , DR 5 ( FMU1 . 5 , 1 . 6 ) , DcR 1 ( FMU1 . 7 ) and DcR 2 ( FMU1 . 8 , 1 . 9 ) . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
Four membrane bound receptors for TRAIL have been identified , two apoptosis mediating receptors , DR 4 and DR 5 , and two apoptosis inhibiting receptors , DcR 1 and DcR 2 . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
Death receptors DR 4 and DR 5 can induce and decoy receptors DcR 1 and DcR 2 can inhibit TRAIL mediated apoptosis . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
DR 5 , DR 4 , and DcR 2 expressed in both cell lines , while no DcR 1 expression was detected . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
Four TRAIL / Apo2L receptors ( DR 4 , DR 5 , DcR 1 , and DcR 2 ) have been identified . ^^^ DR 4 and DR 5 have a death domain , whereas DcR 1 and DcR 2 are called decoy receptors because of their incomplete or lack of a death domain . ^^^ Western blot and flow cytometric analyses revealed that doxorubicin significantly increased the expression of DR 5 , and somewhat up regulated the expression of DR 4 and DcR 2 . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
Furthermore , co methylation patterns were observed for the TRAIL receptor pairs DCR 1 and DCR 2 and between DR 4 and DR 5 . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
DR 5 , DR 4 , and DcR 2 expressed in both cell lines , while no DcR 1 expression was detected . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
Western blot analysis also shows that the low extracellular pH enhanced TRAIL cytotoxicity does not involve modulation of the levels of TRAIL receptors ( DR 4 , DR 5 , and DcR 2 ) , FLIP , inhibitor of apoptosis ( IAP ) , and Bcl 2 . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
Although DR 4 , DR 5 , DcR 1 and DcR 2 can also be detected in the placenta throughout pregnancy , DR 4 and DR 5 staining increased with development whereas DcR 1 and DcR 2 staining decreased . ^^^ Interestingly , at the beginning of the gestation DR 4 and DR 5 staining distributed on the cytotrophoblast mainly , whereas DcR 1 and DcR 2 mainly located in the syncytiotrophoblast cells . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
TRAIL is known to bind to 4 different receptors , 2 proapoptotic ( DR 4 and DR 5 ) , and 2 potentially antiapoptotic receptors lacking death domains ( DcR 1 and DcR 2 ) . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
The combined cytotoxicity of TRAIL and EPI was significantly inhibited by the TRAIL neutralizing fusion protein DR 5 : Fc , although EPI did not affect the mRNA expression of DR 4 , DR 5 , DcR 1 or DcR 2 . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
Recent studies show that death receptors ( DR 4 and DR 5 ) , decoy receptors ( DcR 1 and DcR 2 ) , and death inhibitors ( FLIP , FAP 1 , and IAP ) are responsible for the differential sensitivity to TRAIL of normal and tumor cells . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
TRAIL has been shown to interact with the cell surface through five distinct receptors , named death receptor ( DR ) 4 , DR 5 , decoy receptor ( Dc ) R 1 , DcR 2 , and osteoprotegrin . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
We show that both mRNA and protein of TRAIL receptors death receptors ( DR 4 , DR 5 ) and decoy receptors ( DcR 1 , DcR 2 ) are present in GCT stromal tumor cells . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
Rheumatoid FLS in vitro expressed both death domain containing receptors [ death receptor 4 ( DR 4 ) and DR 5 ] and decoy receptors [ decoy receptor 1 ( DcR 1 ) and DcR 2 ] . ^^^ DR 4 expression on FLS was weak compared with the expression of DR 5 , DcR 1 and DcR 2 . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
Membrane expression of TRAIL receptors DR 4 ( death receptor 4 ) , DR 5 ( pro apoptotic ) , DcR 1 ( decoy receptor 1 ) , DcR 2 ( anti apoptotic ) was assessed by flow cytometry . ^^^ All cell lines expressed DR 4 and DR 5 , but hardly any DcR 1 or DcR 2 . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
The expression levels of DR 4 , DR 5 , DcR 1 and DcR 2 were measured in TRAIL treated and chemotherapeutic agent treated A 549 cells by Western blotting . ^^^ The expression levels of DR 4 and DR 5 were not significantly different and the expression of DcR 2 was slightly downregulated , but the expression of DcR 1 was not detected in non treated , TRAIL treated and chemotherapeutic agent treated A 549 cells . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
TRAIL / FP induced no discernible changes in FLIP , DR 4 , DR 5 , Mcl 1 , or survivin expression , modest declines in levels of DcR 2 and c IAP , but resulted in the marked transcriptional downregulation of XIAP . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
Apo2L / TRAIL is a homotrimeric protein that interacts with five receptors : death receptor 4 ( DR 4 ) and DR 5 mediate apoptosis activation , whereas decoy receptor 1 ( DcR 1 ) , DcR 2 , and osteoprotegerin counteract this function . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
Western blot analysis showed that combined treatment with TRAIL and amiloride did not change the levels of TRAIL receptors ( death receptor ( DR ) 4 , DR 5 , and DcR 2 ( decoy recepter 2 ) or antiapoptotic proteins ( FLICE inhibitory protein ( FLIP ) , inhibitor of apoptosis ( IAP ) , and Bcl 2 ) . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
Expression levels of TRAIL death ( DR 4 and DR 5 ) and decoy ( DcR 1 and DcR 2 ) receptors were not different between primary and metastatic OC cells . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
Epigenetic analysis of HIC 1 , CASP 8 , FLIP , TSP 1 , DCR 1 , DCR 2 , DR 4 , DR 5 , KvDMR 1 , H 19 and preferential 11p15 . 5 maternal allele loss in von Hippel Lindau and sporadic phaeochromocytomas . ^^^ Of four tumour necrosis factor related apoptosis inducing ligand ( TRAIL ) receptors analysed , DR 4 was most commonly methylated ( 41 % ; compared with DcR 2 ( 26 % ) , DcR 1 ( 23 % ) and DR 5 ( 10 % ) ) . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
To address this issue , the extracellular domains ( ECDs ) of DR 4 ( sDR 4 ) , DR 5 ( sDR 5 ) , DcR 1 ( sDcR 1 ) , and DcR 2 ( sDcR 2 ) were expressed in a soluble , monomeric form , and their binding interactions were quantified by surface plasmon resonance . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
The selective tumoricidal activity of TRAIL is believed to be modulated by agonistic ( DR 4 and DR 5 ) and antagonistic receptors ( DcR 1 and DcR 2 ) , which appear to compete for ligand binding . ^^^ Reverse transcriptase polymerase chain reaction ( RTPCR ) was performed to study expression of DR 4 , DR 5 , DcR 1 , and DcR 2 . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
The expression of DR 5 , DR 4 and DcR 2 in both HCC cell lines was detectable , but the expression of DcR 1 was not detectable . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
The expression of TRAIL receptors ( DR 4 , DR 5 , DcR 1 , and DcR 2 ) and the expression of death signal transducing proteins were investigated . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
Western blot analysis showed that combined treatment with TRAIL and amiloride did not change the levels of TRAIL receptors ( DR 4 , DR 5 , and DcR 2 ) and anti apoptotic proteins ( FLIP , IAP , and Bcl 2 ) . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
Here , we have generated and characterised a set of monoclonal antibodies , together with mAbs from the HLDA workshop , against DcR 1 , DcR 2 , DR 4 , DR 5 , TRAIL , APRIL , BAFF , BAFF R , BCMA , and TACI , which may be useful in phenotypic and functional studies of the role of TNF and TNF receptor family in immune function and regulation in relation to health and disease . . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
No changes were observed in DR 4 , DR 5 , DcR 1 , and TRAIL mRNA and protein levels in prostate after castration . ( 2 ) A specific decrease in DcR 2 expression was observed in the ventral prostate after treatment of rats with the anti androgen flutamide . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
Two of them , death receptors 4 and 5 ( DR 4 and DR 5 ) , induce apoptosis , whereas decoy receptors 1 and 2 ( DcR 1 and DcR 2 ) are unable to evoke cell death upon TRAIL binding . ^^^ We observed frequent expression of TRAIL DcR 1 and DcR 2 , while expression of DR 4 and DR 5 was less frequent . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
TSA induced the transcription of TRAIL death receptor DR 5 without affecting the transcription of DR 4 and the decoy receptors ; DcR 1 and DcR 2 . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
BACKGROUND : As advanced prostate cancers are resistant to currently available chemotherapies , we evaluated the cytotoxic effect of TNF related apoptosis inducing ligand ( TRAIL ) and characterized the involvement of its five receptors DR 4 , DR 5 , DcR 1 , DcR 2 , and osteoprotegerin ( OPG ) and of the death inducing signaling complex ( DISC ) forming proteins caspase 8 and c FLIP in prostate cell lines . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
In addition , DcR 1 and DcR 2 inhibit DR 4 and DR 5 mediated , TRAIL induced apoptosis and we demonstrate here that this occurs through distinct mechanisms . ^^^ While DcR 1 prevents the assembly of the death inducing signaling complex ( DISC ) by titrating TRAIL within lipid rafts , DcR 2 is corecruited with DR 5 within the DISC , where it inhibits initiator caspase activation . ^^^ In addition , DcR 2 prevents DR 4 recruitment within the DR 5 DISC . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
TRAIL binds to the proapoptotic death receptors DR 4 and the p 53 regulated proapoptotic KILLER / DR5 as well as to the decoy receptors TRID and TRUNDD . ^^^ The expression level of KILLER / DR5 , TRID , TRUNDD or TRID , and TRUNDD did not correlate with TRAIL sensitivity ( P > 0 . 05 ) . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
The family of tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) receptors , including the pro apoptotic DR 4 and p 53 regulated KILLER / DR5 , as well as the decoys TRID and TRUNDD , are all located on human chromosome 8p21 22 . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
Here , we show that IFNgamma as well as the type 1 interferon IFNalpha strongly inhibit cell surface expression of the decoy receptor TRAILR 4 while having only a moderate inhibitory or even an inducing effect on TRAILR 2 and CD 95 . ^^^
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and Q9UBN6	Pubmed	SVM Score :0.0
NA