| Interacting proteins: O14763 and Q15628 |
Pubmed |
SVM Score :0.0 |
| The involvement of the death adaptor proteins FADD / MORT1 , TRADD , and RIP and the apoptosis initiating caspases 8 and 10 in death signaling by the two death inducing TRAIL receptors 1 and 2 ( TRAIL R 1 and TRAIL R 2 ) are controversial . ^^^ |
|
| Interacting proteins: O14763 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Rather , CARDINAL potently suppressed NF kappaB activation associated with overexpression of TRAIL R 1 , TRAIL R 2 , RIP , RICK , Bcl 10 , and TRADD , or through ligand induced stimulation of the interleukin 1 or tumor necrosis factor receptors . ^^^ |
|
| Interacting proteins: O14763 and Q15628 |
Pubmed |
SVM Score :0.0 |
| CD 95 , TNF related apoptosis inducing ligand ( TRAIL R 1 ) , and TRAIL R 2 bind FADD directly , whereas recruitment to TNF R 1 is indirect through another adaptor TNF receptor associated death domain protein ( TRADD ) . ^^^ |
|
| Interacting proteins: O14763 and Q15628 |
Pubmed |
SVM Score :0.0 |
| In particular , the expression of procaspase 8 gene and subsequent cleavage of caspase 8 were markedly reduced in HL 60 / FAK cells , while expression of TRAIL receptor 2 and 3 , TRADD , and FADD was equivalent in both types of cells . ^^^ |
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| Interacting proteins: O14763 and Q15628 |
Pubmed |
SVM Score :0.0 |
| However , contrary to the previous reports , both DR 4 and DR 5 induced apoptosis can be blocked by dominant negative FADD , and both receptors can activate NF kappaB using a TRADD dependent pathway . ^^^ Thus , both DR 5 and DR 4 use FADD , TRADD , and RIP in their signal transduction pathways , and FADD is the common mediator of apoptosis by all known death domain containing receptors . . ^^^ |
|
| Interacting proteins: O14763 and Q15628 |
Pubmed |
SVM Score :0.0 |
| TRADD and RIP , which bound TNFR 1 , did not bind DR 4 and DR 5 . ^^^ |
|
| Interacting proteins: O14763 and Q15628 |
Pubmed |
SVM Score :0.0 |
| TRAIL / PSI did not affect the level of mRNA expression for TRAIL receptors ( DR 4 , DR 5 , DcR 1 ) and other apoptosis signal transduction molecules ( TRADD , caspase 8 ) . . ^^^ |
|
| Interacting proteins: O14763 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Some members of the DR family , CD 95 and the TRAIL receptors DR 4 and DR 5 , directly bind FADD , whereas others , such as TNF receptor 1 and DR 3 , initially bind another adaptor protein , TRADD , which then recruits FADD . ^^^ |
|
| Interacting proteins: O14763 and Q15628 |
Pubmed |
SVM Score :0.0 |
| NA |
|