| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| Data from immunoblotting analysis reveal that glucose deprivation enhanced TRAIL cytotoxicity is inversely related to the intracellular level of FLICE inhibitory protein ( FLIP ) but not that of death receptor 5 ( DR 5 ) . ^^^ |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| Fas associated protein with death domain ( FADD ) independent recruitment of c FLIPL to death receptor 5 . ^^^ |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| Although chemotherapy treatment did not modulate mRNA or cell surface expression of the TRAIL receptors death receptor 4 , death receptor 5 , decoy receptor 1 , or decoy receptor 2 , it was found to down regulate expression of the caspase 8 inhibitor , c FLIP . ^^^ |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| Arsenic trioxide led to increased cell surface expression of DR 5 ( death receptor 5 ) , inhibition of the serine / threonine kinase Akt and downregulation of the short isoform of FLIP ( FLICE inhibitory protein , FLIPS ) . ^^^ |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| TRAIL sensitivity of the PNET cell lines was correlated with mRNA expression levels of TRAIL , its agonistic ( TRAIL R 1 , TRAIL R 2 ) and antagonistic ( TRAIL R 3 , TRAIL R 4 ) receptors , cellular FLICE like inhibitory protein ( cFLIP ) , caspase 3 and caspase 8 . ^^^ |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| In contrast , the expression of the death receptor KILLER / DR5 ( TRAIL R 2 ) had no effect on FLIP expression , although exogenous p 53 is known to induce KILLER / DR5 expression . ^^^ |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| In HCC cell lines , their TRAIL resistance did not correlate with the basal expression level of TRAIL receptors or c FLIP , however , in human tissues , TRAIL R 1 and TRAIL R 2 expressions were notably decreased compared to normal counterpart . ^^^ |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| Effects of siRNA on FLIP expression were analyzed by Western blotting and RNase protection assay and correlated with TRAIL sensitivity upon stimulation with recombinant soluble TRAIL and TRAIL R 1 and TRAIL R 2 specific agonistic antibodies . ^^^ |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| Sensitization of PSC with culture duration was accompanied by increased expression of CD 95 and TRAIL receptor 2 and no alterations of Flip expression or protein kinase B phosphorylation but was paralleled by the appearance of a COOH terminal cleavage product of receptor interacting protein . ^^^ |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| Susceptibility of these acute leukemia cell types , which are known to lack p 53 ( wt ) function , did not appear to correlate with the levels of the apoptosis signaling death receptors ( DRs ) of Apo 2L , ie , DR 4 and DR 5 ; decoy receptors ( DcR 1 and 2 ) ; FLAME 1 ( cFLIP ) ; or proteins in the inhibitors of apoptosis proteins ( IAP ) family . ^^^ |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| Adriamycin treatment modestly up regulated Apo2L / TRAIL R 2 ( DR 5 ) and had no effect on the expression of Fas associated death domain , c FLIP , Bcl 2 , Bcl ( xL ) , Bax , and IAP family members ( cIAP 1 , cIAP 2 , XIAP , and survivin ) . ^^^ |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| In NHBC , we observed strong associations between the levels of mRNA corresponding to the pro apoptotic molecules , Apo2L / TRAIL , DR 4 , and DR 5 , and those corresponding to pro survival molecules , DcR 1 , DcR 2 , OPG , and FLIP , suggesting that the balance between pro survival and pro apoptotic molecules is a mechanism by which NHBC can resist Apo2L / TRAIL mediated apoptosis . ^^^ |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| Apo2L / TRAIL receptors ( DR 4 , DR 5 , DcR 1 , and DcR 2 ) , c FLIP , Bcl 2 , and other IAP members ( c IAP 1 and c IAP 2 ) were marginally affected at later times in the cells sensitized by Act D . ^^^ |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| Abnormalities of various components of these pathways have been identified in human cancer including loss of FAS expression , deletion or loss of TRAIL receptor DR 4 , mutation of TRAIL receptor DR 5 , overexpression of TRAIL decoy TRID or overexpression of Fas decoy , as well as overexpression of the caspase activation inhibitor , FLIP . ^^^ |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| PS 341 treatment by itself does not affect the levels of Bax , Bak , caspases 3 and 8 , c Flip or FADD , but elevates levels of TRAIL receptors DR 4 and DR 5 . ^^^ |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| Western blot analysis also shows that the low extracellular pH enhanced TRAIL cytotoxicity does not involve modulation of the levels of TRAIL receptors ( DR 4 , DR 5 , and DcR 2 ) , FLIP , inhibitor of apoptosis ( IAP ) , and Bcl 2 . ^^^ |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| Recent studies show that death receptors ( DR 4 and DR 5 ) , decoy receptors ( DcR 1 and DcR 2 ) , and death inhibitors ( FLIP , FAP 1 , and IAP ) are responsible for the differential sensitivity to TRAIL of normal and tumor cells . ^^^ Several researchers have also shown that genotoxic agents , such as chemotherapeutic agents and ionizing radiation , enhance TRAIL induced cytotoxicity by increasing DR 5 gene expression or decreasing the intracellular level of FLIP , an antiapoptotic protein . ^^^ |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| The p 53 protein influences the sensitivity of testicular germ cells to mono ( 2 ethylhexyl ) phthalate induced apoptosis by increasing the membrane levels of Fas and DR 5 and decreasing the intracellular amount of c FLIP . ^^^ Taken together , these data suggest that MEHP induced germ cell apoptosis is dependent , in part , on the p 53 protein and on its abilities to increase the localization of Fas and DR 5 on the germ cell membrane as well as to decrease the cellular levels of c FLIP ( L ) . . ^^^ |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| TRAIL / FP induced no discernible changes in FLIP , DR 4 , DR 5 , Mcl 1 , or survivin expression , modest declines in levels of DcR 2 and c IAP , but resulted in the marked transcriptional downregulation of XIAP . ^^^ |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| Western blot analysis showed that combined treatment with TRAIL and amiloride did not change the levels of TRAIL receptors ( death receptor ( DR ) 4 , DR 5 , and DcR 2 ( decoy recepter 2 ) or antiapoptotic proteins ( FLICE inhibitory protein ( FLIP ) , inhibitor of apoptosis ( IAP ) , and Bcl 2 ) . ^^^ |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| Epigenetic analysis of HIC 1 , CASP 8 , FLIP , TSP 1 , DCR 1 , DCR 2 , DR 4 , DR 5 , KvDMR 1 , H 19 and preferential 11p15 . 5 maternal allele loss in von Hippel Lindau and sporadic phaeochromocytomas . ^^^ |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| From a mechanistic standpoint , we show that CDDO and CDDO Im down regulate the antiapoptotic protein c FLIP ( L ) , and up regulate cell surface TRAIL receptors DR 4 and DR 5 . ^^^ |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| Western blot analysis showed that combined treatment with TRAIL and amiloride did not change the levels of TRAIL receptors ( DR 4 , DR 5 , and DcR 2 ) and anti apoptotic proteins ( FLIP , IAP , and Bcl 2 ) . ^^^ |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| FLIP inhibits chemotherapy induced colorectal cancer cell death . c FLIP inhibits caspase 8 activation and apoptosis mediated by death receptors such as Fas and DR 5 . ^^^ These results indicate that c FLIP inhibits TRAIL independent , DR 5 and caspase 8 dependent apoptosis in response to chemotherapy in CRC cells . ^^^ |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| The synergistic effect is not associated with DR 4 , DR 5 , FADD , and FLIP ( L ) . ^^^ |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : As advanced prostate cancers are resistant to currently available chemotherapies , we evaluated the cytotoxic effect of TNF related apoptosis inducing ligand ( TRAIL ) and characterized the involvement of its five receptors DR 4 , DR 5 , DcR 1 , DcR 2 , and osteoprotegerin ( OPG ) and of the death inducing signaling complex ( DISC ) forming proteins caspase 8 and c FLIP in prostate cell lines . ^^^ |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| Overexpression of DR 5 restores TRAIL signaling pathways and sensitizes the human astrocytes to TRAIL induced apoptosis if CaMKII kinase activity or expression of PEA 15 and c FLIP is inhibited ; the results suggest that CaMKII mediated pathways prevent TRAIL induced apoptosis in human astrocytes under conditions in which TRAIL death receptors are upregulated . ^^^ |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| Furthermore both c FLIP ( S ) and Bcl XL protected against overexpression of the TRAIL receptors DR 4 and KILLER / DR5 . ^^^ |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14763 and O15519 |
Pubmed |
SVM Score :0.0 |
| NA |
|