Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.66662203
Here we show that TRAIL R 1 can associate with TRAIL R 2 , suggesting that TRAIL may signal through heteroreceptor signaling complexes . 0.66662203^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Death receptor 5 , a new member of the TNFR family , and DR 4 induce FADD dependent apoptosis and activate the NF kappaB pathway . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Despite the expression of TRAIL receptors death receptor 4 and death receptor 5 , purified TRAIL could not induce programmed cell death ( PCD ) in any of the thyroid follicular cells examined . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Apo 2 ligand / TNF related apoptosis inducing ligand and death receptor 5 mediate the apoptotic signaling induced by ionizing radiation in leukemic cells . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Ewing ' s sarcoma family tumors are sensitive to tumor necrosis factor related apoptosis inducing ligand and express death receptor 4 and death receptor 5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) related apoptosis inducing ligand ( TRAIL ) induces apoptosis through two receptors , TRAIL R 1 ( also known as death receptor 4 ) and TRAIL R 2 ( also known as death receptor 5 ) , that are members of the TNF receptor superfamily of death domain containing receptors . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
This activation is regulated by the recruitment of an adaptor protein Fas associating death domain ( FADD ) to TRAIL death receptors , death receptor 4 ( DR 4 , TRAIL R 1 ) and death receptor 5 ( DR 5 TRAIL R 2 ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Both cleavage of MEKK 1 and increased expression of death receptor 4 ( DR 4 , TRAILR 1 ) and death receptor 5 ( DR 5 , TRAILR 2 ) occur following exposure of cells to genotoxins . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The RT PCR and Western blotting results demonstrated that the levels of both mRNA and protein for death receptor 4 , death receptor 5 and decoy receptor 2 remained unchanged in response to etoposide , indicating that the synergistic effect of TRAIL and etoposide is not a result of increasing the expression for TRAIL receptors , but rather is associated with amplification of the mitochondrial signal pathway . . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Fas ( CD 95 ) , FasL ( CD95L ) , and TRAIL ( TNF related apoptosis inducing ligand ) with its receptors DR 4 ( Death Receptor 4 ) , and DR 5 ( Death Receptor 5 ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Transformation by oncogenic RAS sensitizes human colon cells to TRAIL induced apoptosis by up regulating death receptor 4 and death receptor 5 through a MEK dependent pathway . ^^^ However , tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) is able to kill specific tumor cells through the engagement of its receptors , death receptor 4 ( DR 4 ) and death receptor 5 ( DR 5 ) , and the activation of apoptotic pathways , providing promising targets for anticancer therapies . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Tumour necrosis factor related apoptosis inducing ligand ( TRAIL ) and antibodies against TRAIL receptors death receptor 4 ( DR 4 ) and death receptor 5 ( DR 5 ) are under investigation for cancer therapy . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Activation of the transcription factor , nuclear factor kappaB ( NF kappaB ) , results in up regulation of not only antiapoptotic genes but also proapoptotic genes , including death receptor 4 ( DR 4 ) and death receptor 5 ( DR 5 ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Although chemotherapy treatment did not modulate mRNA or cell surface expression of the TRAIL receptors death receptor 4 , death receptor 5 , decoy receptor 1 , or decoy receptor 2 , it was found to down regulate expression of the caspase 8 inhibitor , c FLIP . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Like TRAIL R 1 , TRAIL R 2 engages a caspase dependent apoptotic pathway but , in contrast to TRAIL R 1 , TRAIL R 2 mediates apoptosis via the intracellular adaptor molecule FADD / MORT1 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
TRAIL R 2 is structurally similar to the death domain containing receptor TRAIL R 1 ( DR 4 ) , and is capable of inducing apoptosis . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
TRAIL R 4 encodes a 386 amino acid protein with an extracellular domain showing 58 % 70 % identity to those of TRAIL R 1 , TRAIL R 2 , and TRAIL R 3 . ^^^ The signaling capacity of TRAIL R 4 is similar to that of TRAIL R 1 and TRAIL R 2 with respect to NF kappaB activation , but differs in its inability to induce apoptosis . ^^^ Like TRAIL R 1 and TRAIL R 2 , this receptor shows widespread tissue expression . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
When used in solution , one of the anti TRAIL R 2 mAbs was capable of blocking leucine zipper human TRAIL binding to TRAIL R 2 expressing cells and prevented TRAIL induced death of these cells , whereas two of the anti TRAIL R 1 mAbs could inhibit leucine zipper human TRAIL binding to TRAIL R 1 : Fc . ^^^ Furthermore , use of the blocking anti TRAIL R 2 mAb allowed us to demonstrate that the signals transduced through either TRAIL R 1 or TRAIL R 2 were necessary and sufficient to mediate cell death . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Constant co expression of TRAIL and of receptors TRAIL R 1 , TRAIL R 2 , and TRAIL R 3 in different tumor entities as well as in normal brain indicates that additional mechanisms might modulate the previously proposed `` decoy ' ' model . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Two of these receptors , TRAIL R 1 and TRAIL R 2 , contain classical cytoplasmic death domains and are able to transduce an apoptotic signal . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
For TNF R 1 , Fas / APO 1 , DR 3 , DR 6 , TRAIL R 1 and TRAIL R 2 , a conserved ' death domain ' in the intracellular region couples these receptors to activation of caspases . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Past studies have shown that apoptosis mediated by TNF related apoptosis inducing ligand ( TRAIL ) is regulated by the expression of two death receptors [ TRAIL receptor 1 ( TRAIL R 1 ) and TRAIL R 2 ] and two decoy receptors ( TRAIL R 3 and TRAIL R 4 ) that inhibit apoptosis . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) related apoptosis inducing ligand ( TRAIL ) is a member of the TNF family that interacts with several receptors , including TRAIL R 1 , TRAIL R 2 , and TRAIL R 4 . ^^^ TRAIL R 1 and TRAIL R 2 can induce apoptosis of cancer cells and activate the transcription factor NF kappaB . ^^^ Here we show that TRAIL R 1 , TRAIL R 2 , and TRAIL R 4 induced NF kappaB activation are mediated by a TRAF 2 NIK IkappaB kinase alpha / beta signaling cascade but is MEKK 1 independent . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The tumor necrosis factor related apoptosis inducing ligand receptors TRAIL R 1 and TRAIL R 2 have distinct cross linking requirements for initiation of apoptosis and are non redundant in JNK activation . ^^^ Overexpression of the tumor necrosis factor ( TNF ) related apoptosis inducing ligand ( TRAIL ) receptors , TRAIL R 1 and TRAIL R 2 , induces apoptosis and activation of NF kappaB in cultured cells . ^^^ Interestingly , sTRAIL was sufficient for induction of apoptosis only in cell lines that were killed by agonistic TRAIL R 1 and TRAIL R 2 specific IgG preparations . ^^^ Taken together , our data suggest that TRAIL R 1 responds to either cross linked or non cross linked sTRAIL which signals NF kappaB activation and apoptosis , whereas TRAIL R 2 signals NF kappaB activation , apoptosis , and JNK activation only in response to cross linked TRAIL . . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
TRAIL induced apoptosis in humans is mediated by its receptors DR 4 ( TRAIL R 1 ) and DR 5 ( TRAIL R 2 ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Here , we report that ( auto ) antigen specific human T cells are not killed in vitro by soluble TNF related apoptosis inducing ligand ( TRAIL ) although expressing death inducing receptors , TRAIL receptor 1 ( TRAIL R 1 ) and TRAIL R 2 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The involvement of the death adaptor proteins FADD / MORT1 , TRADD , and RIP and the apoptosis initiating caspases 8 and 10 in death signaling by the two death inducing TRAIL receptors 1 and 2 ( TRAIL R 1 and TRAIL R 2 ) are controversial . ^^^ Differential precipitation of ligand stimulated TRAIL receptors demonstrated that FADD / MORT1 and caspase 8 were recruited to TRAIL R 1 and TRAIL R 2 independently of each other . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Although it is known that TRAIL ( Apo2L ) induces apoptosis and activates NF kappaB and Jun N terminal kinase ( JNK ) through receptors such as TRAIL R 1 ( DR 4 ) and TRAIL R 2 ( DR 5 ) , the components of its signaling cascade have not been well defined . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
It is regulated by 2 death receptors , TRAIL receptor 1 ( TRAIL R 1 ) and TRAIL R 2 , and 2 decoy receptors , TRAIL R 3 and TRAIL R 4 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
TRAIL sensitivity of the PNET cell lines was correlated with mRNA expression levels of TRAIL , its agonistic ( TRAIL R 1 , TRAIL R 2 ) and antagonistic ( TRAIL R 3 , TRAIL R 4 ) receptors , cellular FLICE like inhibitory protein ( cFLIP ) , caspase 3 and caspase 8 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Flow cytometric analysis revealed cell surface expression of TRAIL R 1 and TRAIL R 2 on PancTuI and Colo 357 , and TRAIL R 2 on Panc 1 cells . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Here , we demonstrate that all RCC cell lines express TRAIL as well as the death inducing receptors TRAIL R 1 ( DR 4 ) and TRAIL R 2 ( Killer / DR5 ) . ^^^ Neutralization of TRAIL with recombinant soluble TRAIL R 1 Fc and TRAIL R 2 Fc failed to inhibit topotecan induced apoptosis indicating that topotecan induced cell death can occur in a TRAIL independent fashion . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The levels of both TRAIL R 1 and TRAIL R 2 , low in Daudi cells , were enhanced by IFN alpha . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Trail , a tumor necrosis factor related apoptosis inducing ligand , is a novel potent endogenous activator of the cell death pathway through the activation of cell surface death receptors Trail R 1 and Trail R 2 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Differential activation of TRAIL R 1 and 2 by soluble and membrane TRAIL allows selective surface antigen directed activation of TRAIL R 2 by a soluble TRAIL derivative . ^^^ Using antagonistic antigen binding fragment ( Fab ) preparations of TRAIL R 1 and TRAIL R 2 specific antibodies , we demonstrate in this study that TRAIL R 1 becomes activated by both the soluble and the membrane bound form of the ligand , whereas TRAIL R 2 becomes only activated by memTRAIL or soluble TRAIL secondarily cross linked by antibodies . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Rather , CARDINAL potently suppressed NF kappaB activation associated with overexpression of TRAIL R 1 , TRAIL R 2 , RIP , RICK , Bcl 10 , and TRADD , or through ligand induced stimulation of the interleukin 1 or tumor necrosis factor receptors . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
By contrast , HHV 7 infection caused a marked decrease of surface TRAIL R 1 , but not of TRAIL R 2 , CD 95 , TNF R 1 , or TNF R 2 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) , a member of the tumor necrosis factor ( TNF ) family , binds to several cell surface receptors with distinct functions ( agonistic receptors 1 and 2 [ TRAIL R 1 , TRAIL R 2 ] ; decoy receptors 3 and 4 [ TRAIL R 3 , TRAIL R 4 ] ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
BACKGROUND & AIMS : Tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) is a member of the tumor necrosis factor family and induces apoptosis by cross linking either of the 2 TRAIL receptors containing a death domain ( TRAIL R 1 or TRAIL R 2 ) . ^^^ RESULTS : Normal colonic epithelial cells express TRAIL , TRAIL R 1 , TRAIL R 2 , and TRAIL R 4 . ^^^ Using an infection model with restricted human cytomegalovirus gene expression or productive adenovirus infection in the colon carcinoma cell line Caco 2 , we show that TRAIL sensitivity of colonic epithelial cells is induced on virus infection along with an up regulation of TRAIL R 1 and TRAIL R 2 on the cell surface . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Tumour necrosis factor related apoptosis inducing ligand ( TRAIL / APO 2L ) induces apoptosis in a variety of tumour cells upon binding to death receptors TRAIL R 1 and TRAIL R 2 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
It is regulated by 2 death receptors , TRAIL receptor 1 ( TRAIL R 1 ) and TRAIL R 2 and 2 decoy receptors , TRAIL R 3 and TRAIL R 4 . ^^^ In HCC cell lines , their TRAIL resistance did not correlate with the basal expression level of TRAIL receptors or c FLIP , however , in human tissues , TRAIL R 1 and TRAIL R 2 expressions were notably decreased compared to normal counterpart . ^^^ These results suggest that ( a ) the majority of human HCC cell lines are resistant to TRAIL induced apoptosis and cycloheximide sensitive short lived antiapoptotic molecule ( s ) is responsible for this resistance , ( b ) the expression of TRAIL R 1 and TRAIL R 2 is reduced in HCC tissues , and the increased expression of TRAIL R 1 may be a mechanism of cisplatininduced sensitization to TRAIL induced apoptosis in some HCC cells , and ( c ) the activation of NF kappaB may not be involved in the TRAIL resistance of HCC cells . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
RESULTS : For RPE cells derived directly from the eye , we detected mRNAs of Trail R 2 , Trail R 3 , TRAIL , and APO 3 L , but not Trail R 1 , Trail R 4 , and TRAMP . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
TNF related apoptosis inducing ligand ( TRAIL / APO 2L ) is a typical member of the TNF ligand family that induces apoptosis by activating the death receptors TRAIL R 1 and TRAIL R 2 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) induced apoptosis is mediated by its receptors DR 4 ( TRAIL R 1 ) and DR 5 ( TRAIL R 2 ) and the adapter protein Fas associated death domain protein ( FADD ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Low levels of the death inducing TRAIL receptors , TRAIL R 1 and TRAIL R 2 but not the putative ' decoy ' receptors , TRAIL R 3 and TRAIL R 4 , were expressed on the surface of B CLL cells . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
To evaluate the involvement of TRAIL receptors in breast carcinogenesis , we have analyzed the entire coding region of TRAIL R 2 and the death domain ( DD ) regions of TRAIL R 1 and R 4 for the detection of somatic mutations in a series of breast tumors , lymph node metastases and BC cell lines . ^^^ In BC cell lines , a strongly decreased mRNA expression of TRAIL , TRAIL R 1 , R 3 and R 4 was found , whereas the expression of TRAIL R 2 was only slightly reduced . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
TRAIL interacts with four receptors : two signalling receptors ( TRAIL R 1 and TRAIL R 2 ) and two decoy receptors ( TRAIL R 3 and TRAIL R 4 ) . ^^^ A blocking experiment with monoclonal antibodies directed against TRAIL R 1 and TRAIL R 2 revealed that TRAIL R 1 is mainly involved in TRAIL induced apoptosis of ahOL . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
We found no alteration in any death receptors Fas , TRAIL R 1 , TRAIL R 2 , or in their ligands on circulating blood cells . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
RESULTS : In normal colon mucosa , TRAIL and TRAIL R 2 were expressed mostly in the surface epithelium , whereas TRAIL R 1 and TRAIL R 4 were detected all along the crypt axis . ^^^ TRAIL , TRAIL R 2 , TRAIL R 3 , and TRAIL R 4 expression did not correlate statistically with disease free survival ( multivariate analysis : P = 0 . 54 , P = 0 . 67 , P = 0 . 45 , and P = 0 . 69 , respectively ) , but TRAIL R 1 expression was significantly associated with disease free survival in colon cancer ( multivariate analysis : P = 0 . 003 ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Many cancer cell lines preferentially express TRAIL R 1 and TRAIL R 2 , suggesting differential regulation of the death and decoy receptors . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
In addition , we show the presence of Fas , TRAIL R 1 ( Death Receptor 4 , DR 4 ) , and TRAIL R 2 ( DR 5 ) in the testis of C57BL / 6 ( B 6 ) and gld mice ( 4 weeks old ) , and Sprague Dawley rats ( 5 weeks old ) and their responsiveness after MEHP treatment . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
In patients with severe lymphocytic sialadenitis , TRAIL R 1 , TRAIL R 2 , or both were strongly expressed on the ductal epithelial cells . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Somatic mutations of TRAIL R 1 and TRAIL R 2 genes may play a role in the pathogenesis of some tumors . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Using blocking Abs to TRAIL receptors , specifically TRAIL R 2 , and a TRAIL R 1 : FcR fusion protein , we have excluded a role for TRAIL in regulating constitutive neutrophil apoptosis . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The most promising candidate for tumor selective death receptor activation is tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) / Apo2L , which activates the death receptors TRAIL R 1 and TRAIL R 2 , and induces apoptosis preferentially in tumor cells but not in normal tissues . ^^^ Effects of siRNA on FLIP expression were analyzed by Western blotting and RNase protection assay and correlated with TRAIL sensitivity upon stimulation with recombinant soluble TRAIL and TRAIL R 1 and TRAIL R 2 specific agonistic antibodies . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Apo 2L / TRAIL ( tumor necrosis factor related apoptosis inducing ligand ) is a member of the tumor necrosis factor superfamily and has recently been shown to induce apoptosis through engagement of the death receptors TRAIL R 1 ( DR 4 ) and TRAIL R 2 ( DR 5 ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
This resistance was determined by failure to form the TRAIL DISC and by decreased TRAIL R 1 and TRAIL R 2 levels after androgen deprivation ; the capacity of TRAIL to induce DISC formation was completely restored in the presence of DHT . ^^^ Surprisingly , we found that wortmannin decreased the total amount of TRAIL R 1 , but not TRAIL R 2 , in the cells as well as the amount of TRAIL R 1 precipitated by TRAIL . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Eight human DRs ( Fas , TNF R 1 , TRAMP , TRAIL R 1 , TRAIL R 2 , DR 6 , EDA R and NGF R ) have been identified . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Small cell lung cancer cell lines were resistant to FasL and TRAIL induced apoptosis , which could be explained by an absence of Fas and TRAIL R 1 mRNA expression and a deficiency of surface TRAIL R 2 protein . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
CD 95 , TNF related apoptosis inducing ligand ( TRAIL R 1 ) , and TRAIL R 2 bind FADD directly , whereas recruitment to TNF R 1 is indirect through another adaptor TNF receptor associated death domain protein ( TRADD ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Here , we demonstrate that all RCC cell lines coexpress TRAIL and the death inducing receptors , TRAIL R 1 and TRAIL R 2 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
TRAIL ( TNF related apoptosis inducing ligand ) induces apoptosis by cross linking of the two TRAIL receptors that contain a death domain , TRAIL R 1 and TRAIL R 2 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
RT PCR and flow cytometry were performed to monitor TRAIL R 1 and TRAIL R 2 levels after chemotherapeutic treatment . ^^^ Furthermore , the increase in TRAIL / Apo 2L sensitivity following topotecan treatment correlated with increased expression of TRAIL R 1 and TRAIL R 2 and decreased intracellular levels of the antiapoptotic protein survivin . ^^^ The sensitivity of DU 145 cells to TRAIL / Apo 2L was dramatically increased when combined with topotecan , suggesting that low dose topotecan treatment to upregulate TRAIL R 1 and TRAIL R 2 and downregulate survivin , followed by TRAIL / Apo 2L administration , may be a viable therapy for treating cancer of the prostate . . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Using two agonistic mAbs specific for TRAIL R 1 ( DR 4 ) and TRAIL R 2 ( DR 5 ) , we examined the expression and function of these death receptors in RA synovial fibroblast cells . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Of the two TRAIL receptors constitutively expressed by HL 60 ( TRAIL R 1 and TRAIL R 2 ) , only the former was involved in IkappaB degradation , as demonstrated by using agonistic anti TRAIL receptor antibodies . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
These cell lines expressed death receptors TRAIL receptor 1 ( TRAIL R 1 ) and TRAIL R 2 , which were unaltered by treatment with CDDP , as assessed by flow cytometry . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
In an in vitro binding assay , the intracellular domains of both TRAIL R 1 and TRAIL R 2 bound FADD : activation of PKC significantly inhibited this interaction suggesting that PKC may be targeting key apical components of death receptor signaling . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The surface expression of TRAIL R 1 was weakly detectable in the early intermediate phase of erythroid differentiation ( days 4 6 ; dim intermediate GPA expression ) , whereas a clear cut expression of TRAIL R 2 was observed through the entire course of erythroid differentiation ( up to days 12 14 ; bright GPA expression ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Infection of primary cells with adenoviruses carrying the relevant point mutations confirmed the crucial role of these transport motifs for down regulation of Fas , TRAIL R 1 , TRAIL R 2 , and epidermal growth factor receptor . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Human normal hepatocytes are susceptible to apoptosis signal mediated by both TRAIL R 1 and TRAIL R 2 . ^^^ We generated fully human monoclonal antibodies ( mAbs ) that bind specifically to TRAIL receptor 1 ( TRAIL R 1 ) and TRAIL receptor 2 ( TRAIL R 2 ) , which mediate apoptosis signal when they ligate with TRAIL , to investigate the contribution of each receptor to induce tumor cell apoptosis and hepatocyte toxicity . ^^^ All of mAbs to TRAIL R 1 and TRAIL R 2 induced cell death in several cancer cell lines susceptible to TRAIL but not in human umbilical vein endothelial cells in vitro . ^^^ These results indicate that human normal hepatocytes are susceptible to both TRAIL R 1 and TRAIL R 2 mediated apoptosis signal . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Death receptors [ Fas / Apo 1 / CD95 , TNF R 1 [ tumour necrosis factor ( TNF ) receptor 1 ] , DR 3 [ death receptor 3 ] , TRAIL R 1 [ TNF related apoptosis inducing ligand receptor 1 ] , TRAIL R 2 , DR 6 , p 75 NGFR [ p 75 nerve growth factor receptor ] , EDAR [ ectodermal dysplasia receptor ] ] form a subgroup of the TNF R superfamily that can induce apoptosis ( programmed cell death ) via a conserved cytoplasmic signalling module termed the death domain . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The external pathway is mainly triggered by ligation of death receptors such as Fas , tumor necrosis factor ( TNF ) related apoptosis inducing ligand R 1 ( TRAIL R 1 ) , TRAIL R 2 and TNFRp 55 , and mediated by direct activation of upstream caspases . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
However , to exploit fully its therapeutic potential , the characteristics of both the TRAIL receptor system and soluble TRAIL ( sTRAIL ) should be taken into account : first , the widespread expression of the various TRAIL receptors throughout the human body ; second , the differential binding affinities and crosslinking requirements of the agonistic receptors TRAIL R 1 and TRAIL R 2 ; and third , the solution behavior of particular sTRAIL preparations . ^^^ Target antigen binding converted soluble scFvC 54 : sTRAIL into a membrane bound form of TRAIL that was capable of signaling apoptosis not only through TRAIL R 1 but also through TRAIL R 2 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
RESULTS : TRAIL R 1 was constitutively expressed on cultured synovial fibroblasts from RA and OA , however , expression of TRAIL R 2 and TRAIL R 3 was not observed by immunohistochemistry and Western blot . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Human and rat primary sub cultured vascular smooth muscle cells ( VSMCs ) showed clear expression of the death receptors TRAIL R 1 and TRAIL R 2 ; however , recombinant soluble TRAIL did not induce cell death when added to these cells . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
In the present study , we investigated the cellular effects of VPA , TSA and SAHA on four human melanoma cell lines ( WM 115 , WM 266 , A 375 , SK Mel 28 ) with particular reference to the modulation of regulators of apoptosis , including Bcl 2 , BclXL , Mcl 1 , Apaf 1 , BclXs , NOXA , TRAIL R 1 , TRAIL R 2 , caspase 8 , and survivin ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
These glioblastoma cell lines expressed TRAIL R 2 , but not TRAIL R 1 , R 3 , or R 4 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
TRAIL is unusual as compared to the other cytokines of this family , as it interacts with a complex system of receptors consisting of two pro apoptotic death receptors ( TRAIL R 1 and TRAIL R 2 ) and three decoy receptors ( TRAIL R 3 , TRAIL R 4 and osteoprotegerin ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Moreover , experiments performed with agonistic anti TRAIL receptor antibodies demonstrated that both TRAIL R 1 and TRAIL R 2 contributed , although at different levels , to TRAIL induced chemokine modulation . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
RA FLSs were found to express constitutively TRAIL receptors 1 and 2 ( TRAIL R 1 and TRAIL R 2 ) on the cell surface . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Interestingly , neutralization of TRAIL receptor 2 ( TRAIL R 2 ) , but not TRAIL R 1 , impaired apoptosis in a caspase 10 dependent manner , indicating that caspase 10 enhances TRAIL R 2 induced cell death . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Absence of gene mutation in TRAIL receptor 1 ( TRAIL R 1 ) and TRAIL receptor 2 ( TRAIL R 2 ) in chronic myelogenous leukemia and myelodysplastic syndrome , and analysis of mRNA Expressions of TRAIL and TRAIL related genes in chronic myelogenous leukemia . ^^^ We examined gene mutations in the death domains of TRAIL receptor 1 ( TRAIL R 1 ) and TRAIL receptor 2 ( TRAIL R 2 ) , and in the TRAIL gene promoter in 46 chronic myelogenous leukemia ( CML ) patients . ^^^ Furthermore , no mutation in the death domains of TRAIL R 1 and TRAIL R 2 genes , which causes amino acid change , was found in 18 myelodysplastic syndrome ( MDS ) patients . ^^^ In addition , RPA revealed that the ratio of ( TRAIL R 1 plus TRAIL R 2 ) to TRAIL R 3 was also increased after IFN alpha stimulation . ^^^ Taken together , gene mutations of TRAIL R 1 , TRAIL R 2 are infrequent in patients with CML and MDS . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
METHODS : Tissue specimens of 10 tooth germs , 40 benign ameloblastomas , and five malignant ameloblastomas were examined by reverse transcriptase polymerase chain reaction ( RT PCR ) and immunohistochemistry to determine the expression of TNFalpha , TNF receptor 1 ( TNFRI ) , TRAIL , TRAIL receptor 1 ( TRAIL R 1 ) , TRAIL R 2 , caspase 8 , and nuclear factor kappaB ( NF kappaB ) . ^^^ RESULTS : Expression of TNFalpha , TNFRI , TRAIL , TRAIL R 1 , TRAIL R 2 , and NF kappaB mRNA was detected in most samples of normal and neoplastic odontogenic tissues . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Tumour necrosis factor related apoptosis inducing ligand ( TRAIL ) induces apoptosis in a variety of tumour cells through activation of TRAIL R 1 and TRAIL R 2 death signalling receptors . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
In spite of the majority of B CLL lymphocytes expressed variable surface levels of `` death receptors ' ' TRAIL R 1 and TRAIL R 2 , the addition in culture of recombinant TRAIL increased ( > 20 % vs . controls ) the degree of spontaneous apoptosis in only 11 / 44 of the B CLL samples , had no effect in 19 / 44 , while it significantly increased leukemic cell survival in 14 / 44 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
OBJECTIVE : To determine the potential immediate applicability of tumor necrosis factor related apoptosis inducing ligand receptor 1 ( TRAIL R 1 ) and TRAIL R 2 , the apoptotic forms of TRAIL Rs , for preclinical testing . ^^^ DESIGN AND SETTING : Head and neck squamous cell carcinoma ( HNSCC ) tumors were studied for TRAIL R 1 and TRAIL R 2 expression by immunohistochemical analysis . ^^^ MAIN OUTCOME MEASURES : The expression of TRAIL R 1 and TRAIL R 2 and the presence of the TRAIL R 1 polymorphisms C626G and G422A . ^^^ RESULTS : Fewer than 25 % of HNSCC tumor cells expressed TRAIL R 1 and TRAIL R 2 . ^^^ Surrounding tumor infiltrating polymorphonuclear cells expressed TRAIL R 1 and TRAIL R 2 in 12 ( 32 % ) and 14 ( 38 % ) of cases , respectively . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
TRAIL R 1 is distinctively expressed on B lymphocytes , TRAIL R 2 on monocytes , TRAIL R 3 on neutrophils and most impressively , CD8+ lymphocytes and NKT lymphocytes but not CD4+ lymphocytes express TRAIL R4 . . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Contrary to literature reports that TRAIL induced apoptosis occurs primarily via signaling through TRAIL R 2 , CLL cells , in the presence of HDACi , undergo predominantly TRAIL R 1 mediated apoptosis . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
In BT 474 cells , but not SKBr 3 cells , inhibition of the HER2 / phosphatidylinositol 3 ' kinase ( PI3K ) / Akt pathway resulted in downregulation of the pro apoptotic receptors TRAIL receptor 1 ( TRAIL R 1 ) and TRAIL R 2 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Evaluating the expression and prognostic value of TRAIL R 1 and TRAIL R 2 in breast cancer . ^^^ PURPOSE : The cell surface receptors tumor necrosis factor related apoptosis inducing ligand receptor 1 ( TRAIL R 1 ) and TRAIL R 2 transmit apoptotic signals , and agents that activate these receptors are in clinical development . ^^^ We sought to determine the expression and prognostic value of TRAIL R 1 and TRAIL R 2 in early stage breast cancer . ^^^ TRAIL R 1 and TRAIL R 2 expression were similarly studied on 95 unmatched normal breast specimens . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Characterization of 8p21 . 3 chromosomal deletions in B cell lymphoma : TRAIL R 1 and TRAIL R 2 as candidate dosage dependent tumor suppressor genes . ^^^ Gene expression analysis and quantitative reverse transcriptase polymerase chain reaction ( QRT PCR ) showed down regulation of TRAIL R 1 and TRAIL R 2 receptor genes as a consistent event in B NHL with 8p21 . 3 loss . ^^^ Resistance to apoptosis of cell lines with 8p21 . 3 deletion was reversed by restoration of TRAIL R 1 or TRAIL R 2 expression by gene transfection . ^^^ Our data suggest that TRAIL R 1 and TRAIL R 2 act as dosage dependent tumor suppressor genes whose monoallelic deletion can impair TRAIL induced apoptosis in B cell lymphoma . . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Activity of selective fully human agonistic antibodies to the TRAIL death receptors TRAIL R 1 and TRAIL R 2 in primary and cultured lymphoma cells : induction of apoptosis and enhancement of doxorubicin and bortezomib induced cell death . ^^^ TRAIL has four exclusive receptors , two of which ( TRAIL R 1 , TRAIL R 2 ) are death receptors . ^^^ Using two fully human selective agonistic monoclonal antibodies to the TRAIL death receptors TRAIL R 1 ( HGS ETR 1 ) and TRAIL R 2 ( HGS ETR 2 ) this study demonstrated that both monoclonal antibodies activated caspase 8 and induced cell death in five of nine human lymphoma cell lines , and induced > 10 % cell death in 67 % and 70 % , respectively , of 27 primary lymphoma cells , and > 20 % cell death in at least one thirds of the samples . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Five distinct receptors have been described for TRAIL : TRAIL R 1 ( DR 4 ) , TRAIL R 2 ( DR 5 , TRICK ) , TRAIL R 3 ( TRID , DcR 1 ) , TRAIL R 4 ( TRUNDD , DcR 2 ) , and osteoprotegerin . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Previously , we showed that although most adult T cell leukemia / lymphoma ( ATLL ) cells express the TRAIL death receptor DR 4 ( TRAIL R 1 ) or DR 5 ( TRAIL R 2 ) , they are resistant to TRAIL . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
In spite of the presence of TRAIL R 1 and TRAIL R 2 `` death receptors , ' ' recombinant TRAIL was not cytotoxic for tsFHI cells . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The `` decoy receptors ' ' TRAIL R 3 ( TR 3 ) and TRAIL R 4 ( TR 4 ) were believed to negatively regulate TRAIL induced cytotoxicity by competing for ligand binding with TRAIL R 1 ( TR 1 ) and TRAIL R 2 ( TR 2 ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) and its agonistic antibodies , which are currently in early clinical trials for treating various malignancies , induce apoptosis through triggering of either TRAIL R 1 or TRAIL R 2 . ^^^ We have now synthesized mutant forms of TRAIL specific for TRAIL R 1 or TRAIL R 2 . ^^^ Our study highlights the necessity to determine whether primary cells from a particular tumor signal via TRAIL R 1 or TRAIL R 2 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Functional expression of TRAIL receptors TRAIL R 1 and TRAIL R 2 in esophageal adenocarcinoma . ^^^ TRAIL induces apoptosis by interacting with its receptors TRAIL R 1 and TRAIL R 2 . ^^^ Recently , new humanized agonistic anti TRAIL R 1 and anti TRAIL R 2 antibodies have been developed , and are undergoing phase I / II clinical trails . ^^^ The aim of this study was to determine whether human EA tissue express TRAIL R 1 and / or TRAIL R 2 , and whether EA cell lines Bic 1 and Seg 1 expresses functional TRAIL R 1 and / or TRAIL R 2 . ^^^ The expression of TRAIL R 1 and TRAIL R 2 was determined in sections from 18 human EA by immunohistochemistry ( IHC ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Additional in vitro studies revealed that the apoptosis of erythroblasts and the expression of FasL , TRAIL , TRAIL R 1 and TRAIL R 2 was lower in cultures with thalidomide than in control cultures . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The aim of this study was to quantify the expression of the death regulating receptors TRAIL R 1 , TRAIL R 2 and TRAIL on primary GBM specimens and to correlate this expression with survival . ^^^ TRAIL R 2 expression was significantly higher expressed than TRAIL R 1 ( P=0 . 005 ) . ^^^ CONCLUSIONS : TRAIL R 1 and TRAIL R 2 expression on tumor cells are independent prognostic factors for survival in patients with a glioblastoma multiforme . ^^^ As TRAIL R 2 is more expressed , in comparison with TRAIL R 1 , on GBM tumor cells , TRAIL R 2 seems to be of more importance as a target for future TRAIL therapy than TRAIL R1 . . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Mcl 1L cleavage is involved in TRAIL R 1 and TRAIL R 2 mediated apoptosis induced by HGS ETR 1 and HGS ETR 2 human mAbs in myeloma cells . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
PURPOSE : The proapoptotic receptors tumor necrosis factor related apoptosis inducing ligand receptor 1 ( TRAIL R 1 ) and TRAIL R 2 are targets of drugs in clinical development , and receptor expression levels may be important determinants of sensitivity to receptor agonists . ^^^ We assessed TRAIL R 1 and TRAIL R 2 expression patterns in a large cohort of melanomas and benign nevi . ^^^ RESULTS : TRAIL R 1 and TRAIL R 2 expression was higher in melanomas than in nevi ( P < 0 . 0001 ) , and higher in primary than in metastatic specimens ( P = 0 . 0031 and P < 0 . 0001 , respectively ) . ^^^ TRAIL R 1 and TRAIL R 2 expression exceeding the 95th percentile for nevi was found in 19 % and 74 % of melanoma specimens , respectively . ^^^ CONCLUSIONS : TRAIL R 1 and TRAIL R 2 expression is higher in malignant melanocytes than in their benign counterparts , suggesting that these receptors might be effective therapeutic targets in melanoma . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) induces apoptosis in melanoma by interaction with death receptors TRAIL R 1 ( DR 4 ) or TRAIL R 2 ( DR 5 ) on melanoma cells or resists apoptosis by interaction with decoy receptors TRAIL R 3 ( DcR 1 ) or TRAIL R 4 ( DcR 2 ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
TRAIL induced apoptosis is mediated by the transmembrane receptors death receptor 4 ( DR 4 ) ( also known as TRAIL R 1 ) and DR 5 ( TRAIL R 2 ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Expression of TRAIL ( Apo2L ) , DR 4 ( TRAIL receptor 1 ) , DR 5 ( TRAIL receptor 2 ) and TRID ( TRAIL receptor 3 ) genes in multidrug resistant human acute myeloid leukemia cell lines that overexpress MDR 1 ( HL60 / Tax ) or MRP ( HL60 / AR ) . ^^^ TRAIL , a member of the TNF receptor family , induces apoptosis in many tumor cells by binding to DR 4 ( TRAIL receptor 1 ) and DR 5 ( TRAIL receptor 2 ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Susceptibility of the prostate cancer cell types to Apo 2L / TRAIL induced apoptosis did not appear to correlate with the levels of the Apo 2L / TRAIL receptors death receptor ( DR ) 4 ( TRAIL receptor 1 ) or DR 5 ( TRAIL receptor 2 ) , decoy receptor ( DcR ) 1 and DcR 2 , Flame 1 , or the inhibitors of apoptosis proteins family of proteins . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The adenovirus encoded receptor internalization and degradation ( RID ) protein ( previously named E 3 10 . 4K / 14 . 5K ) , which is composed of RIDalpha and RIDbeta subunits , down regulates a number of cell surface receptors in the tumor necrosis factor ( TNF ) receptor superfamily , namely Fas , TRAIL receptor 1 , and TRAIL receptor 2 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
DR 5 ( also called TRAIL receptor 2 and KILLER ) is an apoptosis inducing membrane receptor for tumor necrosis factor related apoptosis inducing ligand ( also called TRAIL and Apo 2 ligand ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
TRAIL receptor 1 ( DR 4 ) and TRAIL receptor 2 ( DR 5 ) were upregulated under the treatment of doxorubicin and verified to be responsible for TRAIL mediated signal transduction . ^^^ TRAIL receptor 1 ( DR 4 ) and TRAIL receptor 2 ( DR 5 ) were upregulated under the treatment of doxorubicin and verified to be responsible for TRAIL mediated signal transduction . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Apoptosis induction by TRAIL in these cells could only be fully inhibited by concomitant blockade of TRAIL receptor 1 and TRAIL receptor 2 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
According to DR serotyping before transplantation both the child and the cadaver kidney proved to be DR 5 , 6 , while the DNA analysis revealed mismatches ; the child possessed the two subtypes : 13b1 and 14a of the DRw 6 antigen only and none of the DR 5 , the cadaver kidney proved to belong to the DR 4 antigen group instead of DR 5 , and furthermore to a different subtype of the DRw 6 ( 13a3 ) than the recipient . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
A decrease in DR 4 and an increase in both DR 5 and the DR 3 subtype found in the A 1 B8 DR 3 haplotype were associated with disease progression ( p less than 0 . 05 ) . . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
They are palindromic pair of hexameric half site ( Thyroid hormone Response Element ; TRE , Estrogen Response Element ; ERE , Glucocorticoid Response Element ; GRE ) or directly repeated half sites [ Direct Repeat ( DR ) 3 , DR 4 , DR 5 ] . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
HLA typing showed that the proband and her fraternal twin sister received DR 5 , DRw 52 , DQw 3 from their father whereas the proband received DR 4 , DRw 53 , DQw 3 from the mother and her sister received DR 2 , DQw 1 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Significantly increased frequencies of HLA DR 5 ( DRw 11 ) ( P = 0 . 009 ) and the Dw 13 ( DRB1 * 0403 , * 0407 ) subtypes of DR 4 ( probability corrected , Pc = 0 . 005 ) were seen in ACA positive patients , and HLA DR 1 and DRw 8 were also increased . ^^^ These findings appeared to reflect linkage disequilibrium of DR 5 ( DRw 11 ) and many DR 4 ( Dw 13 ) haplotypes with HLA DQw 7 and DR 1 with DQw 5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
White patients with alopecia areata have an increase in the phenotype frequencies of DR 4 and DQw 8 and an increase in genotype frequencies of DR 4 and DR 5 ( now DRw 11 [ 5 ] ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The class 2 alleles HLA DR 4 ( 52 . 7 % ) and DR 5 ( 30 . 5 % ) were increased in the patient group compared to 1103 UK Caucasoid controls , but these increases were not statistically significant . ^^^ This can be explained by linkage disequilibrium between the DQw 7 allele at the DQB 1 locus and DRB 1 genes of some DR 4 and all DR 5 haplotypes . ^^^ The polymorphic portion of the DQ alpha chains from DR 4 , DQw 7 and DR 5 , DQw 7 haplotypes differ but they have identical DQ beta chains . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The frequency in AA of the DQB1 * 0301 and DQw 7 associated DQB Bgl / II 4 . 2 kb fragment was increased to 65 . 0 per cent compared to 23 . 2 per cent in controls ( RR = 6 . 1 ; p less than 10 ( 3 ) ) suggesting that the previously reported associations between AA and both DR 4 and DR 5 is secondary to an association between AA and DQB1 * 0301 , which codes for the beta chain of the HLA DQ molecule of the serologically defined HLA DQw 7 specificity . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
This dimorphism at position 86 is widespread , occurring in subtypes of DR 1 , DR 2 , DR 3 , DR 5 , and DR 6 alleles as well as DR 4 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
All but 1 of the 20 patients carried DQw 3 in linkage with HLA DR 4 ( increased significantly with P = 0 . 042 compared with overall normal genotype controls ) or DR 5 . ^^^ The frequency of DQB1 * 0301 in patient haplotypes compared with overall normal DR 4 and DR 5 DQw3 bearing haplotypes was statistically significantly increased ( P less than 0 . 003 , relative risk = 9 . 6 ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
This article presents current models for HLA associated autoimmune disease susceptibility and summarizes the HLA Class 2 alleles currently known to be associated with JRA : primarily DR 8 , DR 5 , DR 6 , and DPw2 . 1 in pauciarticular onset JRA ; and DR 4 in rheumatoid factor positive polyarticular onset JRA . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Thus , the presence of DR 4 , DR 5 and DR 7 in the donor , or of DR 5 in the recipient was associated with an excellent survival , whereas disparities due to the presence of DR 1 and DR 2 in the donor , or of DR 2 , DRw 6 and DR 7 in the recipient were detrimental for the graft . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
In these DR 3 and DR 7 negative patients , DR 4 and DR 5 were significantly more frequent than in the others . ^^^ DR 5 was also significantly more common in these patients compared to controls lacking the same antigens , whereas this did not hold true for DR 4 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
AI IgGs were significantly higher in individuals with the HLA haplotype DR 4 , DRw 53 , DQ 3 and lower in individuals with DR 5 , DRw 52 , DQ 1 ( P = 0 . 03 for both ) . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The groups were : 1 ) DR 1 , DR 2 , and DRw 10 ( 13 haplotypes ) ; 2 ) DR 3 and DRw 6 ( 26 haplotypes ) ; 3 ) DR 5 and DRw 8 ( 24 haplotypes ) ; 4 ) DR 4 , DR 7 , and DR 9 ( 24 haplotypes ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Their HLA restriction molecules were DR 2 , DR 3 , DR 4 , DR 5 , DR 7 , DQ , or DP . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Hashimoto ' s thyroiditis has been shown to be associated with the HLA specificities DR 4 and DR 5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Mouse L cells transfected with DR 1 , DR 2 , DR 4 , DR 5 , and DR 7 were used to confirm the permissive nature of the responses . ^^^ For DR 2 and DR 3 the shortest peptide was residues 6 15 , an additional serine ( residue 5 ) was required for DR 1 and DR 7 and an aspartic acid ( residue 4 ) for DR 4 , DR 5 , and DR 6 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The frequency of HLA B 18 , DR 3 and DR 4 antigens was significantly increased whereas DR 2 , DR 5 and DR 7 were decreased in comparison with 189 healthy unrelated controls without family history of diabetes . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The data suggest a lack of association between A 3 and B 7 antigens and Italian multiple sclerosis and a relevance of other DR locus antigens ( mainly DR 4 and DR 5 ) , in addition to DR 2 , in the susceptibility to the disease . . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Absorption of these patients ' sera with B lymphoblastoid cell lines ( B LCL ) positive for the serologic specificities DR 3 , DR 4 ( Dw 4 , Dw 10 , Dw 14 ) , and DR 5 resulted in EIAs that were negative for HIV . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The donor , the recipient , and an older male sibling were HLA DR 4 , 5 ; the father was presumed homozygous for DR 4 and the mother for DR 5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Using various combinations of specific antigens , the following 5 groups revealed good prognoses , frequently improving within 5 years , 1 ) DR 5 ( + ) and DR 4 ( ) , 2 ) DR 5 ( + ) and DRw 53 ( ) , 3 ) DR 5 ( + ) , DR 4 ( ) and DR 8 ( ) , 4 ) DR 5 ( + ) , DR 4 ( ) and DR 9 ( ) , 5 ) DR 5 ( + ) , DR 4 ( ) , DR 8 ( ) and DR 9 ( ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
An increase of DR 4 and possibly DR 5 in 24 of these patients has previously been reported . ^^^ The frequency of DR 4 was 48 . 8 % compared to 31 . 9 % in controls ( RR = 2 . 0 ) whereas the frequency of DR 5 did not differ from that in controls . ^^^ DPw 4 was not associated ( in linkage disequilibrium ) with DR 4 or DR 5 in patients or controls . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
On the other hand , the DQw 3 molecules from the DR 4 cell lines ( Dw 4 and Dw 10 ) were apparently identical but were polymorphic at least in the light chains among the DR 4 , DR 5 , and DRw 9 haplotypes . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
However , the percentage of DR molecules at the cell surface expressing 21r5 epitope varied with the DR type and increased as follows : DR 3 = DR 7 less than DR 2 less than DR 5 less than DR 4 less than DR 1 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The TA 10 specificity is DQw 3 related and is in linkage disequilibrium with DR 5 ( DRw 11 and DRw 12 ) and it is also weakly associated with DR 4 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The TA 10 specificity is DQw 3 related and is in linkage disequilibrium with DR 5 and weakly associated with DR 4 . ^^^ The molecular and topological analysis has revealed that both TA 10 and IIB 3 determinants were expressed on a single DQ molecule that also carried the DQw 3 determinants on DR 5 and DR 4 cell lines , respectively . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Biochemical analysis of the DQ molecules carried by DQw 3 positive cell lines associated with different DR haplotypes ( DR 4 , DR 5 , DRw 8 , DRw 9 , DRw 12 ) , reveal the presence of at least three different kinds of beta chains carrying the DQw 3 epitope . ^^^ All the cell lines bound by SFR 20 DQ beta 5 ( DR 5 , DRw 8 , and DRw 12 ) possess DQ beta chains of indistinguishable electrophoretic mobility , which are different from the DQ beta chains of DQw 3 cell lines not bound by this antibody while DQw 3 beta chains carried by DR 4 and DRw 9 haplotypes are distinct from DQ beta 5 positive BLCL and from each other . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
HLA DR ( DR 3 , DR 4 , and DR 5 ) and HLA DQ ( DQw2 / DQw3 ) Ag can restrict these T cell responses to human insulin epitopes . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Clone IG 9 recognized a DQw 3 associated determinant expressed on a subset of DR 4 and DR 5 haplotypes and on all DRw 6 , 7 , w 8 , and w 9 haplotypes tested . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Cloned transfectants expressing nine different class 2 molecules were isolated : DR alpha : DR 1 beta 1 , DR alpha : DR 4 beta 1 , DR alpha : DR 5 beta 1 , DR alpha : DR 5 beta 3 ( DRw 52 ) , DR alpha : DR 7 beta 1 , DR alpha : DR4 / 7 beta 4 ( DRw 53 ) , DQ 7 alpha : DQw 2 beta , DQ 7 alpha : DQw 3 beta , and DPw 4 alpha : DPw 4 beta . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
DR 4 and DR 5 antigens were significantly more frequent in DC patients than in a normal population control ( 400 blood donors ) , while DR 3 was less frequent . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
B 18 was also increased in patients with limited sclerosis , while DR 4 and DRw 53 were significantly decreased and DR 5 significantly increased in patients with more extensive skin sclerosis . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The DR 4 haplotype has an additional approximately 110 kb of DNA within the DQ or DR subregions compared to the DR 3 , DR 5 , and DR 6 haplotypes . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Southern blot analysis of genomic DNA from HLA DR 1 through DR 7 homozygous cell lines with DR beta chain gene probes reveals a striking similarity in the pattern of hybridizing fragments between DR 4 and DR 7 haplotypes and among DR 3 , DR 5 , and DRw 6 haplotypes reminiscent of the MT3 / MT2 allodeterminant distribution . ^^^ The sharing of the MT 2 determinant between DR 3 , DR 5 , and DRw 6 haplotypes and of the MT 3 determinant between DR 4 and DR 7 haplotypes is part of a broader `` homology , ' ' which may be a consequence of more recent separation of the haplotypes sharing the MT 2 determinant on the one hand and the haplotypes sharing the MT 3 determinant on the other hand . . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
HLA DR / DQ antigens were studied by the cytotoxicity test using Locus DR / DQ , Terasaki Second DR W 60 Tray and using following antibodies ; DR 1 , DR 2 , DRW 15 , DR 4 , DR 5 , DR 7 , DR 9 , DRW 10 , DRW 8 , DRW 12 , DRW 13 , DRW 6 , DRW 52 , DRW 53 , DQW 1 , DQW 6 , DQW 2 , DQW 3 , DQW 7 and DQW 4 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
DR 2 , DR 3 , DR 4 , DR 5 and DR 7 as well as DRw 52 and DRw 53 are well defined ; other DR specificities are poorly or not at all defined . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
An increase of A 30 , DR 3 , DR 4 , BfF 1 , C4AQ0 and C4BQ0 and decrease of B 40 , DR 2 , DR 5 and DR 6 were found in diabetes when compared to the value observation controls . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The following combinations exerted a beneficial effect on survival : DR 5 and DR 7 Dpos / Rneg for period A , DR 4 Dpos / Rneg and DR 5 Dneg / Rpos for period B , whereas DRw 6 and DR 7 Dneg / Rpos for period A , DR 1 and DR 2 Dpos / Rneg , DR 2 and DRw 6 Dneg / Rpos for period B exerted a detrimental effect . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Serological HLA studies have shown susceptibility to type 1 diabetes is linked to HLA DR 3 and DR 4 allels , whereas DR 2 and DR 5 alleles contain protective elements . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
An increase of A 30 , DR 3 , DR 4 , BfF 1 , C4Ao , and C4Bo and decrease of B 40 , DR 2 , DR 5 , and DR 6 were found in diabetics when compared to the value observed in controls . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Three increased risk phenotypes with twice the expected frequencies or more were HLA DR 1 , DR 4 ; DR 4 and DR 4 , DR 5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
HLA typing also detected the same antigens in both twins : A 2 , B 44 , DR 4 , and DR 5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
First , hybridizations with the 3 ' untranslated sequence of the DR beta cDNA probe , after digestion of the DNA with PvuII ( PvuII DR beta 3 ' ) allows the selective identification of DR 1 , DR 2 and DRw 8 ; DR 3 , DR 5 and DRw 6 are found as one group as well as DR 4 and DR 7 as another . ^^^ The other alleles DR 3 , DR 4 , DR 5 , DRw 6 Dw16 and DR 7 are revealed by dehybridization and rehybridization of the blot with a DR beta cDNA probe . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
These shared hybridizing fragments ( SHFs ) are , for instance , found in individuals typed as DR 4 , DR 5 , DR 7 , and DRw 8 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Individual bands can be identified that are unique to the haplotypes DR 1 , DR 4 , DR 5 , and DR 6 and the DQw 1 and DQw 2 associated haplotypes . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The DR beta EcoRI RFLP pattern of this haplotype is different from the patterns observed for DR 1 , DR 2 , DR 3 , DR 4 , DR 5 , DRw 6 , DR 7 , DRw 8 , DRw 9 , DRw 10 , and appears to be composed of a combination of DR 2 and DRw 6 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Histocompatibility leukocyte antigen DQw 3 is associated with both DR 4 and DR 5 and can be further subdivided by reactivity with the monoclonal antibody TA 10 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Several DR beta RFLP patterns , including those correlating with DR 2 , 4 , 5 , w 6 , 7 and w 8 in Caucasoids , were associated with multiple DQ alpha / DQ beta RFLP haplotypes , of which only two occurred universally one associated with DR 4 and one with DR 5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
When these 57 patients were compared to 249 Caucasian controls similarly lacking DR 3 and DR 4 antigens , there were excesses of DR 1 ( P = 0 . 13 ) and DRW 8 ( P = 0 . 01 ) and deficiencies of DR 2 ( P = 0 . 03 ) and DR 5 ( P = 0 . 03 ) in the patient group . ^^^ Of 187 patients with a single DR 3 and no DR 4 , DR 1 was more frequent ( P = 0 . 02 ) , with DR 2 ( P = 0 . 001 ) and DR 5 ( P = 0 . 02 ) less frequent than 94 HLA DR compatible controls . ^^^ Among 319 patients with a single DR 4 but no DR 3 , DR 1 was again more frequent ( P = 0 . 01 ) and DR 2 ( P = 0 . 001 ) and DR 5 ( P = 0 . 001 ) less frequent than 149 HLA matched controls . ^^^ We conclude that DR 1 is an additional risk DR allele for IDD to that of DR 3 and DR 4 , and DR 5 an additional protective DR allele to that of DR2 . . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Allogenotopes of the four DQ alpha series constitute three clusters correlating with the supertypic groups of class 2 histocompatibility antigens DQw 1 ( DR 1 , DR 2 , and DRw 6 ) , DRw 53 ( DR 4 , DR 7 , and DR 9 ) , and DR 3 plus DR 5 plus DR 8 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
This restriction fragment pattern was found for several haplotypes associated with the DQw 3 specificity , including some haplotypes positive for the HLA DR specificities DR 4 , DR 5 , DRw 8 , and DRw 12 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Removal of DR 3 and DR 4 reveals an overall protective effect of DR 2 , predisposing effects of DR 1 and DRw 8 , and a slight protective effect of DR 5 and a predisposing effect of DRw 6 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
In 16 families typed for HLA DR also , the haplotype predisposing to both IDDM and ATD was assigned from pedigree information to DR 3 ( 44 % ) , DR 4 ( 39 % ) , or DR 5 , DR 6 , or DR 7 ( 5 . 5 % each ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
While the sequences of DR beta chains of the homozygous DR 1 cells , homozygous DR 2 , homozygous DR 4 , DR3 / w6 cells and DR4 / w6 genotypes have been partially or completely characterized , no sequence is yet available for the DR beta chain from a homozygous DR 5 cell . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
V 1 , V 2 , and V 3 derived 24 mers have been synthesized , the DR beta sequences coming from DR 1 , DR 3 , Drw 6 , DR 4 , DR 5 , and DRw 53 haplotypes . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The current knowledge of the relationship between the HLA system and the different forms of Juvenile Chronic Arthritis is reviewed : Of the different forms the Early Onset Pauciarticular JCA is associated with DRw 8 , DR 5 and A 2 , the Polyarticular Onset Rheumatoid Factor positive JCA shows the same pattern of association as does the Adult Rheumatoid Arthritis namely with DR 4 and DR 1 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Strong positive associations were confirmed with HLA antigens A 2 ( pc = 2 . 5 10 10 ( 8 ) ) , DRw 8 ( pc = 3 . 5 10 10 ( 14 ) ) , DR 5 ( pc less than 0 . 02 ) , DRw 52 ( pc = 2 . 8 10 10 ( 6 ) ) and DR 5 , w 8 phenotype ( pc = 3 . 9 10 10 ( 6 ) ) , and negative associations with DR 7 ( pc = 5 . 8 10 10 ( 7 ) ) , DR 4 ( pc less than 0 . 002 ) , and DRw 53 ( pc = 0 . 004 ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
In two separate Swiss multicenter studies on HLA antigens in rheumatoid arthritis , we found an increase in HLA DR 1 and DR 4 and a decrease in HLA DR 5 and DR 7 , when compared with normal controls . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Both HLA DR 3 ( relative risk ( RR ) = 5 . 80 ) and DR 4 ( RR = 2 . 87 ) showed positive associations with Type 1 diabetes mellitus in these patients whilst DR 2 ( RR 0 . 16 ) and DR 5 ( RR = 0 . 15 ) were negatively associated . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The Type 2 diabetic patients could be distinguished from blood donors by increased frequencies of Cw 4 , DR 4 , DR 5 and DR3 / DR4 , and from Type 1 diabetic patients by increased frequencies of B 7 , DR 2 , DR 5 and decreased frequency of A 9 , Bw 22 and DR 4 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
In addition , these comparisons indicate that DQw 3 alpha from DR 5 is different from DQw 3 alpha from DR 4 , but identical to DQw 2 alpha from DR 3 . ^^^ In contrast , DQw 3 beta from DR 5 is very similar to DQw 3 beta from DR 4 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Alleles at one of these loci are assumed to code for DR beta chains carrying the DR alloespecificities DR 1 , DR 2 , DR 3 , DR 4 , DR 5 , DRw 6 , DR 7 , and DR 8 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The phenotype frequencies of all but one HLA DR antigens , DR 4 , DR 5 , DRw 8 , and DRw 9 associating with DQw 3 , were observed to increase ( patient vs . control : DR 4 , 65 vs . 41 . 4 % ; DR 5 , 10 vs . 4 . 3 % ; DRw 9 , 20 vs . 23 % ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The heavy and light chain subunits of MB 3 molecules were isolated from KT 2 ( DKT 2 , DR 4 , MB 3 homozygous ) , ER ( Dw 4 , DR 4 , MB 3 homozygous ) , JMe ( Dw 5 , DR 5 , MB 3 homozygous ) , EBV Sh ( DSh , DRw6 . 2 , MB 3 homozygous ) , and EBV Ky ( DKy , DRw 9 , MB 3 homozygous ) cells and were compared with one another by two dimensional gel electrophoresis . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The recognition of subgroups of DR 4 , DR 5 , and DR 7 , and the specificities LB 12 and LB 13 are described . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Monoclonal antibody IVD 12 was used to isolate and characterize a human Ia molecule present on B cells that generally display DR 4 or DR 5 phenotypes . ^^^ In each family , individuals positive for IVD 12 binding were also positive for DR 4 or DR 5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
These studies also revealed that MT 1 molecules isolated from DR 1 and DR 2 cell lines were different , as were MB 3 molecules isolated from DR 4 and DR 5 cell lines . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Furthermore , MT 1 molecules from DR 1 , DR 2 , and DRw 6 cell lines are structurally different as are MB 3 molecules from DR 4 and DR 5 cell lines . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The monoclonal antibody PLM 12 reacted with B cells carrying DR 4 , DR 5 , DRw6 . 2 , and DRw 9 phenotypes , and its reactivity perfectly correlated with the previously defined TB 21 ( MB 3 like ) specificity . ^^^ Class 2 molecules detected by PLM 12 were structurally distinct from those precipitated by the anti DR monoclonal antibody NC 1 on all HLA DR 4 , DR 5 , DRw6 . 2 , and DRw 9 homozygous cell lines and showed polymorphism in heavy and light chains among these cell lines . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The antibody IVD 12 reacted with all HLA DR 4 and two of three DR 5 positive B cell lines suggesting that it recognized a specificity similar to MB 3 . ^^^ The intensity of fluorescence was greater on DR 5 ( + ) cell lines than on DR 4 ( + ) cell lines relative to the amount of a nonpolymorphic Ia determinant . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
In both the concordant and discordant groups there was a high prevalence of the antigens DR 3 and DR 4 , a low prevalence of DR 5 and DR 7 , and a virtual absence of DR 2 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
In addition to these DR antigens , two other B cell alloantigen systems ( MT and MB ) were proposed on the basis of the serologic data ( 3 , 4 ) ; the MB 1 or MT 1 specificities are found in association with DR 1 , DR 2 , and DRw 6 , whereas MT 2 is associated with DR 3 , DR 5 , DRw 6 , and DRw 8 ; MT 3 is associated with DR 4 , DR 7 , and DRw 9 , and MB 3 or MT 4 is associated with DR 4 , DR 5 , and DRw 8 , respectively ( 3 , 4 ) . ^^^ We have also described that the TB 21 antigen is expressed in association with DR 4 , DR 5 , and DRw 9 ( 5 ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The reactive pattern of TA 10 was closely associated with DR 5 and its related DR antigen NJ 2 , and also found with DR 4 or DRw 9 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The data obtained confirm the association of DR 4 with RA , and reveal an increased risk of disease for patients carrying DR 1 , DR 2 , and DR 3 , compared to the risk for those carrying other antigens , such as DR 5 , DRw 6 , and DR 7 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Compared to controls Type 1 diabetics had increased frequencies of B 8 , CW 3 , and DR 4 and decreased frequencies of DR 5 and DR 7 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Significant positive associations between IDDM and HLA B 8 , DR 3 , DR 4 , BfS , and BfF 1 were confirmed , as were significant negative associations between IDDM and HLA B 7 , DR 2 , DR 5 , DR 7 , and BfF . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Primary structural variation among serologically indistinguishable DS antigens : the MB 3 bearing molecule in DR 4 cells differs from the MB 3 bearing molecule in DR 5 cells . ^^^ HLA DS molecules bearing the MB 3 supertypic specificity have been isolated from two DR 4 and two DR 5 homozygous cell lines by using the monoclonal antibody IVD 12 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Anti 70K reactivity and antibody titer were positively associated with a basic amino acid residue , arginine or histidine , at position 13 ( DR 2 or DR 4 ) and were negatively associated with the amino acid sequence Ile , Leu , Glu , and Asp at positions 67 70 , which was present in some of the DR 5 , DR 6 , and DR 8 associated alleles , in the DRB 1 beta 1 domain . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The commonest HLA A , B and DR antigens at MEDUNSA are A 30 , A 9 , A 2 , A 10 , A 28 ; B 17 , B 12 , B 42 , B 8 ; DR 3 , DR 5 and DR 4 ( in this order of frequency ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Direct repeats of this sequence are a functional TRE when spaced by 4 but not by 5 bp ( DR 4 versus DR 5 ) . ^^^ TR bound as monomers , homodimers and heterodimers with retinoid 10 receptor ( RXR ) to both DR 4 and DR 5 , with an approximately 10 fold greater affinity for DR 4 due to reduced dissociation of the protein DNA complex . ^^^ Phasing analysis indicated that both TR / RXR and TR homodimer induced bends of approximately 10 degrees in DR 4 , but caused little bending of DR 5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
We use 9 sequence specific primers and 2 group specific primers to define the HLA DRB 1 specificities DR 1 , DR 2 , DR 3 , DR 4 , DR 5 , DR 6 , DR 7 , DR 8 , DR 9 and DR 10 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Coexpression of UR in COS 1 cells inhibited the stimulation of chloramphenicol acetyltransferase ( CAT ) reporter gene expression by hRXR alpha and human retinoic acid receptor alpha in the presence of all trans retinoic acid when DR 4 ( but not DR 5 ) was present upstream of the promoter of a CAT reporter gene ( DR 4 CAT ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Patients with the HLA A 9 , B 8 , B 15 , B 18 , DR 3 , DR 4 presented with significant shifts in the immunity status as against those with the HLA A 1 , A 10 , B 5 , B 12 , B 16 , B 27 , DR 5 , DR7 . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
However , in the majority of patients the disease onset had multifactorial nature , as there were HLA antigen associations by DR 4 , DR 5 , DR 7 , DRw 53 , DQw 3 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Six patients and 18 donors were also oligotyped for the subtypes of DR 1 , DR 3 , DR 4 and DR 5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Our data confirm that polyarticular JCA with early childhood onset ( < or = 4 years ) is associated with DR 5 and DR 8 and has a different immunogenetic background from polyarticular JCA with later childhood ( > 4 years ) onset ( associated with DR 4 ) . . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Dimerization interfaces formed between the DNA binding domains determine the cooperative binding of RXR / RAR and RXR / TR heterodimers to DR 5 and DR 4 elements . ^^^ We have now mapped the dimerization surfaces located in the DBDs of RXR , RAR and TR , which are responsible for cooperative interaction on DR 4 ( RXR and TR ) and DR 5 ( RXR and RAR ) . ^^^ The D box of the C terminal CII finger of RXR provides one of the surfaces which is specifically required for the formation of the heterodimerization interfaces on both DR 4 and DR 5 . ^^^ Heterodimerization with the RXR DBD on DR 5 specifically requires the tip of the RAR CI finger as the complementary surface , while a 7 amino acid sequence encompassing the ' prefinger region ' , but not the TR CI finger , is specifically required for efficient dimerization of TR and RXR DBDs on DR 4 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Heterodimer activity was strongest on a DR 5 reporter gene , and the strength of activation of the reporter series ( DR 5 > DR 1 > DR 3 > DR 2 = IR 0 = DR 4 ) correlated with the ability of the heterodimer to bind to the corresponding sequences in vitro . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
In the Lennox Gastaut group we found a significant increase in the frequency of DR 5 antigen ( 55 % , chi 2 = 5 . 6 ) , and an indication of a decrease in the frequency of DR 4 antigen ( 0 % , chi 2 = 3 . 0 ) as compared with controls ( 20 % and 28 % , respectively ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Increased frequencies of HLA A 2 , Cw 4 , Cw 5 , DR 4 , DR 5 and DR 7 have been observed in patients with liver cirrhosis and previous HBV infection , while a lower frequency of HLA A 2 and higher frequencies of HLA A 3 , B 35 , Cw 4 , DR 3 have been observed in patients without previous HBV infection when compared with controls . . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Thirty nine cases of 44 ( 88 . 6 % ) had DR 4 or DR 9 and HLA genotypes of DR4 / DR 5 , 6 , 8 and DR9 / DR5 , 6 , 8 were significantly increased as compared with those in the control subjects ( P < 0 . 001 ) . ^^^ These findings suggested that HLA haplotypes associated with DR 4 DQ4 , DR 4 DQ3 and DR 9 DQ3 as well as those associated with DR 5 , 6 , 8 might be involved in susceptibility to IgA nephropathy , while A24Cw B52DR2DQ1 haplotype might be resistant to the disease development . . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
We have examined vitamin D receptor ( VDR ) , thyroid hormone receptor ( TR ) , and retinoid 10 receptor beta ( RXR beta ) binding to vitamin D response elements ( VDREs ) , two thyroid hormone response elements ( TREs ) ( DR 4 and F 2 ) , and a retinoic acid response element ( DR 5 ) . ^^^ VDR / RXR bound well to the VDREs and to DR 4 and DR 5 using the electrophoretic mobility shift assay . ^^^ In co transfection experiments using CV 1 cells , we observed that VDR repressed basal transcription in the absence of ligand on DR 3 and osteopontin VDREs and F 2 , but had no effect on DR 4 or DR 5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Site specific mutagenesis of cloned TCR genes and transfection into Jurkat cells were used to demonstrate that single amino acid substitutions in CDR 2 of the TCR alpha chain controlled whether a T cell was restricted by the product of a single DR allele ( DR 7 ) or would respond to the HA 307 319 peptide when presented by the products of one of several different DR alleles ( DR 1 , DR 4 , DR 5 , or DR 7 ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Finally , DRB 6 , which is one of the oldest DRB genes , has been lost in the HLA DRB 3 ( or DR 52 ) group of haplotypes ( DR 3 , DR 5 , DR 6 and DR 8 ) and a small DRB 6 sequence is present at the exon 2 first hypervariable region of DRB 4 ( or DR 53 ) gene , which is present in DR 4 , DR 7 and DR 9 haplotypes . . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The haplotypes A 1 , B 17 ; A 2 , B 5 ; A 2 , B 51 ; A 1 , DR 7 ; B 12 , DR 7 ; B 13 , DR 2 ; B 17 , DR 7 ; DR 2 , DQ 1 ; DR 3 , DQ 2 ; DR 4 , DQ 3 ; DR 5 , DQ 3 ; DR 7 , DQ 2 ; DR 11 , DQ 3 ; show significant positive linkage disequilibrium whereas A 1 , DR 2 ; DR 2 , DQ 2 ; DR 7 , DQ 1 were significant for negative linkage disequilibrium in the Dravidian Hindus . . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
As reported in other populations , most of the patients without DR 3 were heterozygous for DR 7 and DR 11 or 12 ( DR 5 ) , or had DR 4 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Seven HLA antigens , i . e . , HLA A 9 , B 5 , B 12 , B 16 , DR 4 , DR 5 , and Drw 6 , suggested possible associations with symptoms and / or atopy indicators . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
We sequenced approximately 1400 base pairs of the segment encompassing the DRB 9 locus from eight human haplotypes ( DR 1 , DR 10 , DR 2 , DR 3 , DR 5 , DR 6 , DR 8 , and DR 9 , the DR 4 and DR 7 having been sequenced by others earlier ) , as well as two chimpanzee , five gorillas , one orangutan and one macaque haplotype . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Its binding affinities were found to be high for DR 1 , moderate for DR 2 , DR 7 and DR 8 , low for DR 4 , DR 5 , DR 6 and DR 9 , and below detection for DR 3 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
HLA typing revealed high frequencies ( > 10 % ) of alleles HLA A 2 , A 9 , A 11 , B 17 , B 35 , B 40 , DR 2 , and DR 7 in both tribes , but the Irula had elevated HLA A 10 , B 8 , and DR 8 frequencies and the Malayali had elevated HLA A 31 , B 7 , DR 4 , and DR 5 frequencies . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
We demonstrate that , in contrast to the polarity of RXR / TR and RXR / RAR bound to DR 4 and DR 5 elements respectively , PPAR binds to the 5 ' extended half site of the response element , while RXR occupies the 3 ' half site . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Like DR 4 , DR 5 engages the apoptotic pathway independent of the adaptor molecule FADD / MORT1 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The predominant antigens in decreasing order of frequency were B 35 , B 39 , and B 61 at the B locus ; DR 4 , DR 5 , and DR 8 at the DR locus ; and DQ 3 at the DQ locus . ^^^ On the other hand , the most common HLA DR , HLA DQ haplotypes were DR 4 , DQ 3 and DR 5 , DQ 3 with a frequency higher than 10 % . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Three closely related receptors bind Apo2L : DR 4 and DR 5 , which contain cytoplasmic death domains and signal apoptosis , and DcR 1 , a decoy receptor that lacks a cytoplasmic tail and inhibits Apo2L function [ 3 5 ] . ^^^ The DcR 2 gene mapped to human chromosome 8p21 , as did the genes encoding DR 4 , DR 5 and DcR 1 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Univariate analysis revealed higher frequencies of DR 2 ( odds ratio [ OR ] , 4 . 8 ; 95 % confidence interval [ CI ] , 1 . 2 18 . 8 ) and DR 5 ( OR , 7 . 5 ; 95 % CI , 1 . 5 37 . 5 ) but lower frequencies of DR 4 ( OR , 2 . 3 ; 95 % CI , 1 . 1 4 . 9 ) and DR 6 ( OR , 2 . 8 ; 95 % CI , 1 . 4 5 . 8 ) , in rubella vaccinees compared with placebo recipients with arthropathy . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
TRAIL is a tumor necrosis factor related ligand that induces apoptosis upon binding to its death domain containing receptors , DR 4 and DR 5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
APO2L ( TRAIL ) is a novel CD95L ( Fas / APO 1 L ) homologous cytotoxic cytokine that interacts with various receptors which transmit ( DR 4 , DR 5 ) or inhibit ( DcR 1 , DcR 2 ) an apoptotic signal . ^^^ Here , we report that human glioma cell lines preferentially express mRNAs for agonistic death receptors DR 4 ( 8 / 12 ) and DR 5 ( 11 / 12 ) rather than the death inhibitory decoy receptors DcR 1 ( 4 / 12 ) and DcR 2 ( 2 / 12 ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Apoptotic signals are transduced by five death domain containing receptors TNFR 1 , Fas , DR 3 , DR 4 , and DR 5 by binding to their ligands . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Two additional members of this family , DR 4 and DR 5 , transduce apoptotic signals upon binding soluble TNF related apoptosis inducing ligand ( TRAIL ) that , like FasL , belongs to the growing TNF family of molecules . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
AP 02 ligand ( APO2L ) is a CD 95 ligand ( CD95L ) related cytokine of the tumor necrosis factor family that interacts with agonistic ( DR 4 , DR 5 ) and antagonistic ( DcR 1 , DcR 2 ) receptors . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Activating TRAIL receptors DR 4 and DR 5 were expressed in all normal and malignant breast cell lines . ^^^ DR 4 , DR 5 , or TRID expression did not correlate with sensitivity to TRAIL induced apoptosis . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
We found a significant excess of HLA DR 1 ( odds ratio 1 . 64 , 95 % CI 1 . 16 2 . 33 , attributable risk 5 . 0 % ) and DR 5 antigens ( odds ratio 1 . 47 , 95 % CI 0 . 99 2 . 18 , attributable risk ) among patients with dilated cardiomyopathy but not of HLA DR 4 as previously reported . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Analysis by Northern blotting demonstrated mRNAs encoding TRAIL as well as the four TRAIL receptors ( DR 4 , DR 5 , DcR1 / TRID , DcR2 / TRUNDD ) in human placentas . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
In the frequencies of DR 4 and DR 5 , there were significant differences between patients fulfilling Sharp ' s ( 60 . 9 % , 56 . 5 % ) and controls ( 24 . 3 % , P < 0 . 005 , RR = 4 . 7 and 21 . 4 % , P < 0 . 005 , RR = 4 . 6 % ) , but there were no significant differences between the patients not fulfilling Sharp ' s and normal control ( P > 0 . 05 ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Both DR 4 and DR 5 have recently been identified as membrane death receptors that are activated by their ligand TRAIL to engage the intracellular apoptotic machinery . ^^^ TRID protects from TRAIL induced apoptosis by competing with DR 4 and DR 5 for binding to TRAIL . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Because the soluble extracellular domains of the death receptors CD 95 , DR 4 and DR 5 failed to block anoikis , we conclude that ligand dependent activation of these death receptors is not involved in this process . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Gel shift experiments with the probe ( AUB ) corresponding to the consensus Alu sequence just upstream of the RNA polymerase 3 promoter B box and containing duplicated AGGTCA motif indicate that the probe interacts in a sequence specific manner with human nuclear proteins which bind to standard IR 0 , DR 1 , DR 4 or DR 5 elements . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
One receptor , called DR 5 , contains a cytoplasmic death domain and signals apoptosis much like DR 4 . ^^^ The DR 4 and DR 5 mRNAs are expressed in many normal tissues and tumor cell lines . ^^^ The third receptor , called DcR 2 , is structurally similar to DR 4 and DR 5 but has a truncated cytoplasmic death domain and does not transmit a death signal . ^^^ Transfection experiments indicate that DcR 1 and DcR 2 act as decoys that prevent Apo2L from inducing apoptosis through DR 4 and DR 5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Formation of a complex between Apo2L ( also called TRAIL ) and its signaling receptors , DR 4 and DR 5 , triggers apoptosis by inducing the oligomerization of intracellular death domains . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Death receptors for FasL ( Fas ) and for TRAIL ( DR 4 , DR 5 ) are emerging as important regulators of drug induced apoptosis in human cancers , mediated by caspase activation . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
TRAIL , the ligand for the newly discovered DR 4 and DR 5 receptor , is a member of the TNF family of death signal transduction proteins with a mechanism of cell death similar to that of Fas and Fas ligand ( Fas L ) system . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
We could demonstrate an association between PCA and the HLA DR 5 haplotype ( P = 0 . 001 ) as well , but not with HLA DR 3 and / or DR 4 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The mechanism of the synergistic effect results from the etoposide mediated increase in the expression of the death receptors 4 ( DR 4 ) and 5 ( DR 5 ) . ^^^ Inhibition of NF kappaB activation by expression of kinase inactive MEK kinase 1 ( MEKK 1 ) or dominant negative IkappaB ( DeltaIkappaB ) blocked the increase in DR 4 and DR 5 expression following etoposide treatment . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
TRAIL , the ligand for the newly discovered DR 4 and DR 5 receptor is a member of the tumour necrosis factor ( TNF ) family of death signal tranduction proteins with a mechanism of cell death , similar to the Fas and Fas ligand ( Fas L ) system . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) is a potent endogenous activator of the cell death pathway and functions by activating the cell surface death receptors 4 and 5 ( DR 4 and DR 5 ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Expression of TRAIL ( a ligand for DR 4 and DR 5 ) was significantly lower in CCSK and RTK than in normal kidney ( 9 . 5+ / 1 . 5 % 5 . 56 . 1+ / 10 . 1 % ; P = . 01 ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) is a novel member of the tumor necrosis factor ( TNF ) family that induces apoptosis preferentially in tumor cells through binding to its cognate death receptors , DR 4 and DR 5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
These results indicate that BCR ligation activates an apoptotic signaling pathway distinct from Fas mediated apoptosis in WEHI 231 cells , and that BCR mediated apoptosis of WEHI 231 cells does not require Fas or related molecules such as DR 3 , DR 4 and DR 5 , as all of these death receptors require FADD / MORT1 and / or CrmA sensitive caspases for induction of apoptosis . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
It mediates its apoptotic effects through one of two receptors , DR 4 and DR 5 , which are members of of the TNF receptor family , and whose cytoplasmic regions contain death domains . ^^^ However , although apoptosis depends on the expression of one or both of the death domain containing receptors DR 4 and / or DR 5 , resistance to TRAIL induced apoptosis does not correlate with the expression of the `` decoy ' ' receptors . ^^^ Although DR 4 , DR 5 , DcR 1 , and OPG show similar affinities for TRAIL at 4 degrees C , their rank ordered affinities are substantially different at 37 degrees C , with DR 5 having the highest affinity ( K ( D ) < / = 2 nm ) and OPG having the weakest ( K ( D ) = 400 nm ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The TNF homolog Apo2L / TRAIL triggers apoptosis through two distinct death receptors , DR 4 and DR 5 ; however , receptor over expression studies have yielded conflicting results on the ligand ' s signaling mechanism . ^^^ Apo2L / TRAIL induced homomeric and heteromeric complexes of DR 4 and DR 5 and stimulated recruitment of FADD and caspase 8 and caspase 8 activation in nontransfected cells . ^^^ TRADD and RIP , which bound TNFR 1 , did not bind DR 4 and DR 5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
We now show that the binding of TNF related , apoptosis inducing ligand ( TRAIL ) to its cellular receptors DR 5 ( TRAILR 2 ) and DR 4 ( TRAILR 1 ) mediates reovirus induced apoptosis . ^^^ In addition , reovirus induces both TRAIL release and an increase in the expression of DR 5 and DR 4 in infected cells . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Recently , several tumor necrosis factor receptor 1 ( TNF R 1 ) and Fas related death receptors have been discovered and include DR 3 , DR 4 , DR 5 and DR 6 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
TNF related apoptosis inducing ligand ( TRAIL ) is a more recently identified member of the TNF superfamily that has been shown to selectively kill neoplastic cells by engaging two cell surface receptors , DR 4 and DR 5 . ^^^ We addressed the expression of Fas , DR 4 , and DR 5 in thyroid carcinoma cell lines and in 31 thyroid carcinoma specimens by Western blot analysis and immunohistochemistry , respectively , and tested the sensitivity of thyroid carcinoma cell lines to Fas and TRAIL induced apoptosis . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
However , TGF beta treatment of BL 41 cells was found not to affect the cell surface expression of Fas , TNF R 1 , DR 3 , DR 4 , or DR 5 , or the steady state expression levels of Fas ligand , TNF R 1 , DR 3 , DR 4 , and DR 5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
CD 437 increased the expression of c Myc , c Jun , c Fos , and death receptors DR 4 , DR 5 and Fas . ^^^ Because CD 437 induced the expression of DR 4 , DR 5 and Fas , we examined the effects of combining CD 437 and tumor necrosis factor ( TNF ) related apoptosis inducing ligand ( TRAIL ) and Fas ligand , respectively , in HPC cells . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
CONCLUSIONS : Identical HLA DR 3 , DR 4 and DR 5 antigens were found more frequently in preeclampsia , while identical DR 4 and DR 6 in the antiphospholipid syndrome . . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
CONCLUSION : These genetic studies suggest that HLA DR molecules DR 2 , DR 5 , and possibly DR 4 or DR 7 contribute to susceptibility while HLA DQ 2 contributes to resistance and that a combination of these genetic elements determines the outcome of ABPA in patients with cystic fibrosis and asthma . . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
DR 5 ( but not DR 4 ) was expressed at high level in all cell lines . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Susceptibility of these acute leukemia cell types , which are known to lack p 53 ( wt ) function , did not appear to correlate with the levels of the apoptosis signaling death receptors ( DRs ) of Apo 2L , ie , DR 4 and DR 5 ; decoy receptors ( DcR 1 and 2 ) ; FLAME 1 ( cFLIP ) ; or proteins in the inhibitors of apoptosis proteins ( IAP ) family . ^^^ Treatment of human leukemic cells with etoposide , Ara C , or doxorubicin increased DR 5 but not DR 4 , Fas , DcR 1 , DcR 2 , Fas ligand , or Apo 2L levels . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) induces apoptosis via the death receptors DR 4 and DR 5 in different transformed cells in vitro and exhibits potent antitumor activity in vivo with minor side effects . ^^^ CD 437 up regulated DR 4 and DR 5 expression . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
TRAIL triggers apoptosis by binding to its two proapoptotic receptors DR 4 and DR 5 , a process which is negatively regulated by binding of TRAIL to its two decoy receptors TRID and TRUNDD . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
To investigate the therapeutic potential of TRAIL , we analyzed the expression of TRAIL and its apoptosis inducing receptors ( DR 4 and DR 5 ) in the normal and cancerous human pancreas , and the sensitivity of pancreatic cancer cells to TRAIL cytotoxicity . ^^^ TRAIL , DR 4 and DR 5 mRNA levels were concomitantly increased in pancreatic cancers compared with normal controls ( P < 0 . 01 ) , and there were positive correlations between the expression levels of TRAIL and DR 4 , TRAIL and DR 5 and between DR 4 and DR 5 mRNA ( r=0 . 85 , r=0 . 87 , r=0 . 91 ; P < 0 . 01 ) . ^^^ In five pancreatic cancer cell lines , TRAIL , DR 4 and DR 5 mRNA expression was detectable at various levels . ^^^ However , independent of the presence of DR 4 and DR 5 , TRAIL cytotoxicity assays revealed that pancreatic cancer cells showed a significantly lower sensitivity ( LD ( 50 ) > 85 ng / ml ) to TRAIL treatment than Jurkat T lymphoma cells ( LD ( 50 ) =7 . 2 ng / ml ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
At least two direct repeats of AGGTCA like sequences with 4 base spacing ( DR 4 ) and five base spacing ( DR 5 ) , in previously identified bile acid response elements of the rat CYP7A1 were able to bind LXRalpha / RXRalpha and confer LXRalpha stimulation . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) alpha related apoptosis inducing ligand ( Apo 2L / TRAIL ) , after binding with its signaling death receptors ( DR 4 and DR 5 ) , triggers the intrinsic `` mitochondrial ' ' pathway of apoptosis more efficiently in the cancer than do normal cells . ^^^ Reduced effects of Apo 2L / TRAIL in Bcr Abl positive leukemic cells were not attributable to diminished expression of DR 4 and DR 5 , or higher expressions of the decoy receptors DcR 1 and 2 or c FLIP ( L ) . ^^^ Cotreatment with STI 571 significantly enhanced Apo 2L / TRAIL induced apoptosis ( P < 0 . 01 ) as well as increased the processing of caspase 9 and 3 and XIAP , without affecting the levels of DR 4 , DR 5 , decoy receptors , or c FLIP ( L ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
TRAIL ( tumour necrosis factor related apoptosis ligand or Apo2L ) triggers apoptosis through engagement of the death receptors TRAIL R 1 ( also known as DR 4 ) and TRAIL R 2 ( DR 5 ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
It is well known that TRAIL binds to the death signaling receptors , DR 4 and DR 5 , and initiates the TRAIL death pathway . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Apo 2 ligand tumor necrosis factor related apoptosis inducing ligand ( Apo2L / TRAIL ) is a member of the tumor necrosis factor family that interacts with cell surface `` death receptors ' ' ( DR 4 and DR 5 ) to initiate programmed cell death . ^^^ Apo 2 ligand tumor necrosis factor related apoptosis inducing ligand ( Apo2L / TRAIL ) is a member of the tumor necrosis factor family that interacts with cell surface `` death receptors ' ' ( DR 4 and DR 5 ) to initiate programmed cell death . ^^^ Apo2L / TRAIL also binds to `` decoy ' ' receptors ( DcR 1 and DcR 2 ) that can antagonize its interaction with DR 4 and DR 5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Four related receptors bind TRAIL , two death receptors ( DR 4 and DR 5 ) that signal apoptosis and two decoy receptors ( DcR 1 and DcR 2 ) that act as dominant negative inhibitors of TRAIL mediated apoptosis . ^^^ Our results indicate that overexpression of cRel or activation of endogenous Rel / NF kappaB factors by TNFalpha in HeLa cells up regulates DcR 1 without changing the expression of DcR 2 , DR 4 , and DR 5 and makes cells resistant against TRAIL induced apoptosis . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
TRAIL induces apoptosis via death receptors ( DR 4 and DR 5 ) in a wide variety of tumor cells but not in normal cells . ^^^ These data suggest that death receptors ( DR 4 and DR 5 ) and Fas receptors induced apoptosis through identical signaling pathway , and TRAIL induced apoptosis via both mitochondrial dependent and independent pathways . . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Although three other TRAIL receptors DR 5 , DcR 1 , and DcR 2 are induced by DNA damage and are regulated by the wild type p 53 tumor suppressor , it was not known whether these factors also affect DR 4 expression . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
TRAIL ( tumor necrosis factor ( TNF ) related apoptosis inducing ligand ) , a recently identified member of the growing TNF superfamily , binds to its cognate `` death ' ' receptors DR 4 and DR 5 as well as `` decoy ' ' receptors DcR 1 and DcR 2 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
TRAIL / PSI did not affect the level of mRNA expression for TRAIL receptors ( DR 4 , DR 5 , DcR 1 ) and other apoptosis signal transduction molecules ( TRADD , caspase 8 ) . . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
These alterations result in amino acid changes in or near the ligand binding domain of DR 4 and , based on the crystal structure of DR 5 and its homology with DR 4 , have the potential to affect TRAIL binding to DR 4 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
However , it did not change the mRNA expression level of death mediating TRAIL receptors , e . g . , DR 4 and DR 5 , which were constitutively expressed in both cell lines . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The TRAIL mechanism induced 2 APO was blocked by the caspase 6 inhibitor , VEID , and by the soluble fusion proteins , DR 4 or DR 5 , which act as decoy receptors . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
No changes in the expressions of TRAIL receptors ( DR 4 and DR 5 ) and Bcl 2 or Bax were found after treatment . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Sulindac sulfide specifically up regulated the DR 5 levels but had no effect on the levels of other DRs including DR 4 , Fas , and tumor necrosis factor receptor 1 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Platelets do not express the death receptors Fas , DR 4 and DR 5 on their plasma membrane , while the expression of the decoy receptor DcR 2 increases progressively during platelet storage . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Transcripts for the 14 receptors to which the ligands bind , six of which contain death domains ( TNFR 1 , Fas , DR 3 , DR 4 , DR 5 , DR 6 ) , were also identified using RT PCR . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
These studies showed that CD120a and DR 3 are significantly phosphorylated by p 42 ( mapk / erk2 ) but Fas , DR 4 and DR 5 are not . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Graves ' disease ( GD ) is associated with the histocompatibility leucocyte antigen ( HLA ) haplotype A * 01 B * 0801 DRB1 * 0301 DQA1 * 0501 DQB1 * 0201 ( or B8 / DR3 ) whereas autoimmune hypothyroidism ( AIH ) has been weakly associated with HLA DRB1 * 03 , * 04 and * 11 / * 12 alleles ( or DR 3 , DR 4 and DR 5 ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
TRAIL ( TNF related apoptosis inducing ligand ) induces apoptosis in susceptible cells by binding to death receptors 4 ( DR 4 ) and 5 ( DR 5 ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
AZT and IFN alpha mediated apoptosis in PEL was blocked by stable overexpression of dominant negative Fas Associated Death Domain ( FADD ) , decoy receptor 2 ( DcR 2 ) , soluble TRAIL receptor fusion proteins ( DR 4 and DR 5 ) and thymidine . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
These uPAR deficient transfected cells had higher levels of the TRAIL receptors DR 4 and DR 5 than did the control and vector population as detected by flow cytometry . ^^^ An RNase protection assay confirmed the elevation of DR 4 and DR 5 mRNA in the antisense uPAR cells . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
DAP 3 also associates with the pro caspase 8 binding adapter protein Fas associated death domain ( FADD ) , and links FADD to the TRAIL receptors DR 4 and DR 5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
RESULTS : The most frequent HLA DR and HLA DQ alleles were : DR 5 ( 11 ) ( gene frequency 0 . 138 ) , DR 4 ( gene frequency 0 . 083 ) , DR 1 ( gene frequency 0 . 077 ) , DQ 1 ( gene frequency 0 . 388 ) , DQ 3 ( gene frequency 0 . 197 ) , and DQ 2 ( gene frequency 0 . 09 ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
RESULTS : The phenotypic frequencies of HLA A 1 , A 2 , A 9 , A 11 , A 24 , B 5 , B 35 , B 40 , Cw 4 , DR 2 , DR 3 , DR 4 , DR 5 and DR 7 were increased while frequencies of HLA A 10 , A 19 , A 26 , A 32 , B 7 , B 14 , B 16 , B 21 , B 22 , B 27 , B 37 , Cw 2 , DR 1 and DR 9 were decreased when compared with other populations from , Maharashtra . ^^^ The phenotype frequencies of HLA A 26 , A 28 , A 30 , B 18 , B 40 , B 56 , Cw 3 , Cw 4 , DR 3 , DR 4 and DR 5 were increased while the frequencies of HLA B 7 , B 15 , B 16 , B 22 , B 37 , Cw 2 , Cw 6 , DR 1 and DR 9 were decreased when compared with frequencies in other Indian populations . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Fas and Trail receptors ( DR 4 and DR 5 ) are TNF family members and act as death signal transduction proteins in the apoptosis cascade . ^^^ Despite the importance of PA in lung cancer treatment , the function of Fas , DR 4 and DR 5 in PA induced apoptosis , as well as the effect of their respective ligands FasL and TRAIL alone or in combination with PA , remains poorly understood . ^^^ All the lung cancer cells express Fas , FasL , DR 4 and DR 5 ; however PA did not significantly modify their levels . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
CADD interacts with death domains of tumor necrosis factor ( TNF ) family receptors TNFR 1 , Fas , DR 4 , and DR 5 but not with the respective downstream adaptors . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Upon binding of tumour necrosis factor ( TNF ) related apoptosis inducing ligand ( TRAIL ) , the agonistic TRAIL receptors DR 4 and DR 5 activate caspase 8 leading to apoptosis . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
DR dependency was analyzed in FADD dominant negative or cytokine response modifier A overexpressing cells , and a possible role for DR 4 and DR 5 was investigated by antagonistic antibodies . ^^^ The sequence of events suggested the involvement of a DR , as indicated by an early role for Fas associated death domain and caspase 8 , followed by cleavage of Bid and the disruption of mitochondria ; nonetheless , we failed to demonstrate the involvement of DR 4 and DR 5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
IFN gamma or TRAIL treatment alone did not change expression of other pro or antiapoptotic proteins such as DR 4 , DR 5 , FADD , Bax , IAP 1 , XIAP , Bcl 2 , and Bcl XL . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
This regulation of TRAIL mediated apoptosis by inflammatory cytokines appears to be due to alterations of cell surface expression of TRAIL receptor DR 5 and not DR 4 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
FasL and TRAIL are apoptotic ligands of the TNF like cytokines family , acting via activation of the transmembrane death domain containing receptors Fas for FasL , and DR 4 or DR 5 for TRAIL . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
METHODS : We investigated the presence and functional status of TRAIL and its receptors , DR 4 , DR 5 , and DcR 2 on tumor as well as tumor infiltrating lymphocytes ( TIL ) in primary ( n=37 ) , and metastatic gastric carcinoma from malignant ascites ( n=37 ) by a flow cytometry . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
These cells express messenger RNA for the death receptors Fas , tumor necrosis factor receptor 1 ( TNF R 1 ) , death receptor 4 ( DR 4 ) , and DR 5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
We found that HL 60 cells , which express TRAIL receptors ( also called death receptor , DR ) DR 4 , DR 5 , and Dc ( decoy ) R 2 , are highly sensitive to TRAIL induced cytotoxicity . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
TRAIL can bind to four different receptors , two pro apoptotic death receptors ( DRs ) , DR 4 and DR 5 , and two antiapoptotic decoy receptors ( DcRs ) , DcR 1 and DcR 2 . ^^^ We studied the tumor specific down regulation of the TRAIL receptors DcR 1 and DcR 2 , as well as DR 4 and DR 5 , in a group of pediatric tumor cell lines [ nine neuroblastoma and three peripheral primitive neuro ectodermal tumors ( PNETs ) ] and three cell lines from adult tumors . ^^^ DR 4 and DR 5 were expressed in 8 of 15 and 12 of 15 cell lines , respectively . ^^^ DR 4 and DR 5 were methylated in 5 ( 71 % ) of 7 and 2 ( 67 % ) of 3 nonexpressing cell lines , respectively . ^^^ In addition , we performed mutation analysis of the death domains of DR 4 and DR 5 by sequencing exon 9 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
CD 437 selectively increased the p 53 protein level and concomitantly induced the expression of several p 53 regulated apoptosis related genes including Bax , Fas , DR 4 , and DR 5 only in the two lung cancer cell lines . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Among T cells , CEM underwent apoptosis in response to CH 11 but were resistant to Trail in agreement with the absence of Trail receptors ( DR 4 and DR 5 ) on their surface . ^^^ As B cell lines expressed significant levels of DR 4 and DR 5 , resistance to Trail in SKW 6 . 4 is likely due to the expression of the decoy receptor DcR 1 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
TG selectively upregulated DR 5 but had no effect on the expression of the other TRAIL receptor , DR 4 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Its potent apoptotic activity is mediated through its cell surface death domain containing receptors , DR 4 and DR 5 . ^^^ However , the augmentation of Apo2L / TRAIL effects by chemotherapy was associated with drug induced up regulation of death receptors DR 4 and DR 5 mRNA and protein . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The sequential treatment produced the greatest induction of DR 5 and DR 4 , caspase 3 like cleavage / activation and p 21 degradation , as well as increased apoptosis . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Western analysis demonstrated that increased apoptotic response of PC3AR cells may be due to differential response of death receptors DR 4 , DR 5 and decoy receptors DcR 1 and DcR 2 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Analysis of putative transcription factor binding sites within the enhancers revealed DR 5 and DR 4 type recognition sequences for nuclear receptors . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
TRAIL binds four different membrane bound receptors : DR 4 , DR 5 , DcR 1 , and DcR 2 . ^^^ The DR 4 and DR 5 receptors mediate apoptosis , whereas the others do not . ^^^ We demonstrated by reverse transcriptase polymerase chain reaction and flow cytometry that , in vitro , normal human articular chondrocytes express the receptors mediating apoptosis ( DR 4 and DR 5 ) and one of the decoy receptors ( DcR 2 ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Significantly higher proliferative responses were detected when streptococcal pyrogenic exotoxin ( Spe ) A was presented by cells expressing DQA1 * 0101 / DQB1 * 0302 ( DQ3 . 2 ) , as compared to cells expressing DR 1 , DR 4 , or DR 5 alleles ( p=0 . 0002 0 . 01 ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
We determined whether forced COX 2 expression modulates apoptosis induction by tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) , a member of tumor necrosis factor ligand family , and examined determinants of the apoptotic pathway , including membrane death receptors ( DR 4 and DR 5 ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Cytoplasmic and cell surface expression of the TRAIL receptors DR 4 and DR 5 was observed in this patient ' s tumor by immunohistochemistry . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
We have investigated the expression , in human osteoblast like cells ( NHBC ) , of Apo2L / TRAIL and the known Apo2L / TRAIL death receptors , DR 4 and DR 5 , and the Apo2L / TRAIL decoy receptors , DcR 1 , DcR 2 , and osteoprotegerin ( OPG ) . ^^^ In NHBC , we observed strong associations between the levels of mRNA corresponding to the pro apoptotic molecules , Apo2L / TRAIL , DR 4 , and DR 5 , and those corresponding to pro survival molecules , DcR 1 , DcR 2 , OPG , and FLIP , suggesting that the balance between pro survival and pro apoptotic molecules is a mechanism by which NHBC can resist Apo2L / TRAIL mediated apoptosis . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Here , we demonstrate that the expression of both TRAIL / Apo 2 ligand and the death receptors ( DR ) DR 5 and DR 4 , but not Fas , are sustained in IL 6 differentiated Ig secreting human plasma cells as well as primary mouse plasma cells generated in a T dependent immune response . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
This was confirmed by quantitative immunocytochemical image analysis of BAL eosinophils and alveolar macrophages , which demonstrated that expression levels of TRAIL and DcR 2 increased , whereas expression levels of the TRAIL Rs DR 4 and DR 5 decreased in asthmatic subjects after SAC . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Apo2L / TRAIL receptors ( DR 4 , DR 5 , DcR 1 , and DcR 2 ) , c FLIP , Bcl 2 , and other IAP members ( c IAP 1 and c IAP 2 ) were marginally affected at later times in the cells sensitized by Act D . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Selenium specifically upregulated DR 5 expression but not that of DR 4 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
HLA association studies revealed that the predisposition to develop ABPA is associated with HLA DR 2 and DR 5 , and possibly DR 4 or DR 7 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Because CASP 8 is a key component of the death inducing signaling complex ( DISC ) when specific death receptors ( including DR 4 , DR 5 , FAS ) are activated by their specific ligands ( TRAIL / FASL ) , we examined expression of the components of the DISC complex in lung cancer cell lines . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
TRAIL receptor mRNAs ( DR 4 , DR 5 , and DcR 2 ) were induced by doxorubicin but these changes were not reflected at the protein level . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The sensitivity to TRAIL was correlated with cell surface expression of death inducing receptors DR 4 and / or DR 5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
AIM : To observe the localization of TRAIL / TRAIR ( DR 4 , DR 5 , DcR 1 , DcR 2 ) in the fetal pancreas . ^^^ There were a few DcR 1 and DcR 2 positive cells whereas there were no immunoreactive cells of DR 4 and DR 5 in the pancreas islets . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Death receptor ( DR ) dependency was analyzed by examining expression of DRs ( Fas , DR 4 , DR 5 , TNFR 1 , and R 2 ) , and interaction of Fas associated death domain and caspase 8 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Enhancement of TRAIL / Apo2L mediated apoptosis by adriamycin through inducing DR 4 and DR 5 in renal cell carcinoma cells . ^^^ ADR increased the expression of DR 4 and DR 5 in RCC cells , but not in the normal kidney cells . ^^^ Furthermore , the synergistic cytotoxicity was significantly inhibited by DR 4 : Fc and DR 5 : Fc fusion proteins , which inhibit TRAIL / Apo2L mediated apoptosis . ^^^ These findings indicate that ADR sensitizes RCC cells to TRAIL / Apo2L mediated apoptosis through induction of DR 4 and DR 5 , suggesting that the combination therapy of TRAIL / Apo2L and ADR might be effective for RCC therapy . . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Death receptors include tumor necrosis factor receptor 1 , Fas , death receptor ( DR ) 3 , DR 4 , DR 5 and DR 6 , whereas death ligands include tumor necrosis factor a , lymphotoxin , Fas Ligand , Apo 3 Ligand and TRAIL ( TNF Related Apoptosis Inducing Ligand ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Tumor necrosis factor related apoptosis inducing ligand stimulates the extrinsic apoptoticpathway by binding to death receptors 4 ( DR 4 ) and 5 ( DR 5 ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Apoptosis assays and Western blot analyses revealed that apoptosis resistance to TRAIL correlates well with the level of Akt phosphorylation at Ser 473 rather than protein expression levels of TRAIL receptors , DR 4 and DR 5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Abnormalities of various components of these pathways have been identified in human cancer including loss of FAS expression , deletion or loss of TRAIL receptor DR 4 , mutation of TRAIL receptor DR 5 , overexpression of TRAIL decoy TRID or overexpression of Fas decoy , as well as overexpression of the caspase activation inhibitor , FLIP . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Using two agonistic monoclonal antibodies specific for each death receptor of TRAIL , 2E12 ( anti human DR 4 ) and TRA 8 ( anti human DR 5 ) , we examined the signal transduction of the death receptors in combination with or without chemotherapy agents such as Adriamycin ( doxorubicin hydrochloride ) and Cisplatin . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Adenovirus mediated p 53 overexpression resulted in up regulation of the death receptors Fas , DR 4 and DR 5 with subsequent caspase mediated apoptosis of the oligodendrocytes . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The effects of Epo B and / or Apo 2L / TRAIL on the protein expressions of the death receptors DR 4 and DR 5 as well as of XIAP and survivin were determined by immunoblot analyses . ^^^ Epo B increased the expressions of DR 4 and DR 5 , as well as augmented Apo 2L / TRAIL induced processing of caspase 8 and Bid . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
When Colo 205 cells were cultured with 50 % CM A , cell surface expression of TRAIL death receptors DR 5 and DR 4 increased 13 fold and sixfold , respectively , compared with that of untreated Colo 205 cells . ^^^ CONCLUSION : Macrophages from cancer patients appear to be activated by tumor cells to produce TRAIL and to increase the expression of TRAIL death receptors DR 4 and DR 5 on tumor cells . . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
In epithelial cells , reovirus induced apoptosis involves the release of tumor necrosis factor ( TNF ) related apoptosis inducing ligand ( TRAIL ) from infected cells and the activation of TRAIL associated death receptors ( DRs ) DR 4 and DR 5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
In this study , we examined the ability to eliminate the hyperplastic synovium by adenoviral mediated gene transfer of human TNF related apoptosis inducing ligand ( TRAIL ) , a member of the TNF family that is able to induce apoptosis through interaction with receptors containing death domains , DR 4 and DR 5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
To determine the molecular mechanisms involved in the enhanced apoptosis , we examined the expression of two TRAIL death receptors ( DR 4 and DR 5 ) and two TRAIL decoy receptors ( DcR 1 and DcR 2 ) . ^^^ We found that treatment with I3C induced DR 4 and DR 5 expression at both transcriptional and translational levels . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
This correlated with the lack of p 55 TNFRI , Fas , DR 4 , and DR 5 expression . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
PMA also increased the expression of TRAIL receptors DR 4 and DR 5 ; this expression was inhibited by the PKC inhibitors GF109203x , G6983 , and Ro 31 8220 and the MEK inhibitor UO 126 , suggesting a role for conventional PKC isoforms and MEK in the regulation of TRAIL receptor expression . ^^^ CONCLUSIONS : PKC stimulation in PANC 1 cells increases expression of the pro apoptotic gene Bad and the TRAIL receptors , DR 4 and DR 5 , through both conventional PKC and MEK dependent pathways . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Among TRAIL receptors , death receptor 4 ( DR 4 ) and DR 5 containing death domain ( DD ) in their cytoplasmic region mediate apoptosis signaling upon TRAIL binding , while decoy receptor 1 ( DcR 1 ) and DcR 2 with a truncated or non functional DD play `` decoy ' ' role . ^^^ Preparation and characterization of a set of monoclonal antibodies to TRAIL and TRAIL receptors DR 4 , DR 5 , DcR 1 , and DcR 2 . ^^^ In this study , we raised hybridomas secreting monoclonal antibodies against TRAIL ( FMU1 . 1 , 1 . 2 , 1 . 3 ) , DR 4 ( FMU1 . 4 ) , DR 5 ( FMU1 . 5 , 1 . 6 ) , DcR 1 ( FMU1 . 7 ) and DcR 2 ( FMU1 . 8 , 1 . 9 ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
DR 4 expression was increased when Jurkat cells were treated with TRAIL , and DR 5 expression increased after exposing Molt 4 cells to TRAIL plus a low dose of doxorubicin for 24 h . ^^^ The expression of DR 4 and DR 5 in UCB mononuclear cells was unchanged after treatment with TRAIL , a low dose doxorubicin , or TRAIL plus a low dose of doxorubicin . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Importantly , treatment of resistant cells with the chemotherapeutic agents doxorubicin , cisplatin and etoposide reversed the resistance to Apo2L / TRAIL , which was associated with drug induced upregulation of mRNA encoding the death receptors DR 4 and DR 5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Four membrane bound receptors for TRAIL have been identified , two apoptosis mediating receptors , DR 4 and DR 5 , and two apoptosis inhibiting receptors , DcR 1 and DcR 2 . ^^^ DR 4 and DR 5 staining was stronger in neoplastic cells than in normal cells and was accompanied by a higher degree of apoptosis . ^^^ In conclusion , marked changes were seen in the course of the adenoma carcinoma sequence with respect to the expression of TRAIL and TRAIL receptors DR 4 and DR 5 . ^^^ The stronger expression of DR 4 and DR 5 in neoplastic cells than in normal cells , together with a higher degree of apoptosis , suggests a possible functional role for these receptors in apoptosis induction in neoplastic colorectal cells . . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Electrophoretic mobility shift assays demonstrate that cTR 2 binds the canonical direct repeat DNA recognition sequences spaced by one , four , and five nucleotides ( DR 1 , DR 4 , and DR 5 ) , and in consistence with the results with canonical DNA binding sequences , cTR 2 forms specific DNA protein complex with chicken phenobarbital response elements containing DR 4 motifs . ^^^ Moreover , transient transfection studies reveal its capability to transactivate canonical DR 1 , DR 4 , and DR 5 sequences and the constitutive activity of cTR 2 is mapped to the N terminal region of this orphan receptor . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Death receptors DR 4 and DR 5 can induce and decoy receptors DcR 1 and DcR 2 can inhibit TRAIL mediated apoptosis . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
RESULTS : Both DR 4 and DR 5 were present in all HCC tissues as well as normal hepatic tissues . ^^^ DR 5 , DR 4 , and DcR 2 expressed in both cell lines , while no DcR 1 expression was detected . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
PS 341 treatment by itself does not affect the levels of Bax , Bak , caspases 3 and 8 , c Flip or FADD , but elevates levels of TRAIL receptors DR 4 and DR 5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Four TRAIL / Apo2L receptors ( DR 4 , DR 5 , DcR 1 , and DcR 2 ) have been identified . ^^^ DR 4 and DR 5 have a death domain , whereas DcR 1 and DcR 2 are called decoy receptors because of their incomplete or lack of a death domain . ^^^ Western blot and flow cytometric analyses revealed that doxorubicin significantly increased the expression of DR 5 , and somewhat up regulated the expression of DR 4 and DcR 2 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
TRAIL induces apoptosis through its interaction with its two proapoptotic death receptors ( DRs ) , DR 4 and DR 5 . ^^^ We hypothesized that decreased expression of DRs DR 4 and DR 5 may contribute to TRAIL resistance . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
In particular , RSV infection strongly up regulated the expression of tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) and its functional receptors death receptor 4 ( DR 4 ) and DR 5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
To investigate the therapeutic potential of rhTRAIL , the expression of TRAIL and its apoptosis inducing receptors DR 4 and DR 5 was evaluated in tumors of stage 3 NSCLC patients . ^^^ DR 4 , DR 5 , and TRAIL expression were determined immunohistochemically in 87 tumors . ^^^ RESULTS : DR 4 , DR 5 , and TRAIL were expressed in 99 % , 82 % , and 91 % of the tumors , respectively . ^^^ Seventeen percent of the samples expressed only DR 4 and no DR 5 . ^^^ In NSCLCs with squamous cell differentiation , a typical staining pattern for DR 4 and DR 5 was observed . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Surface expression of TRAIL receptors DR 4 and DR 5 was analysed by FACS . ^^^ RESULTS : Jurkat T cells express the agonistic DR 5 receptor but not DR 4 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
TRAIL induces apoptosis in Adriamycin resistant MCF 7 cells already expressing high levels of death receptors DR 4 and DR 5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Furthermore , co methylation patterns were observed for the TRAIL receptor pairs DCR 1 and DCR 2 and between DR 4 and DR 5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Of the two TRAIL death receptors ( DR 4 and DR 5 ) , melanoma cells primarily expressed DR 5 on cell surface . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Treatment with ADM increased expression of DR 4 and DR 5 but not Fas , whereas treatment with TXL increased expression of Fas but not DR 4 and DR 5 in MDA MB 231 cells . ^^^ Although treatment of MCF 7 cells with ADM increased expression of DR 4 and DR 5 but not Fas , expression of DR 4 , DR 5 , and Fas by the drug resistant cells did not change following treatment with ADM . ^^^ Activation of Fas , DR 4 , and DR 5 in drug sensitive cells in response to anticancer drugs is dependent on the cytotoxic effect of each drug . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Not only did this lead to cooperatively enhanced RXR homodimer binding to DR 1 or DR 5 elements , but unexpectedly , the mutant acquired significant binding efficiency for noncognate DR 3 or DR 4 elements as well . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Other death receptors , such as tumor necrosis factor receptor , DR 4 , and DR 5 do not bind to CaM . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The apoptotic signals by these cytokines are transduced by eight different death domain ( DD ) containing receptors ( TNFR 1 , also called DR 1 ; Fas , also called DR 2 ; DR 3 , DR 4 , DR 5 , DR 6 , NGFR , and EDAR ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Generally , sensitivity to FasL GFP correlated with cell surface FasR levels , but no such correlation was seen for TRAIL and its functional receptors , DR 4 and DR 5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
DR 5 , DR 4 , and DcR 2 expressed in both cell lines , while no DcR 1 expression was detected . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The TRAIL apoptotic signaling pathway has also been implicated in genotoxin induced apoptosis through upregulation of TRAIL death receptors DR 4 and DR 5 . ^^^ In the present study , we demonstrate that the treatment of primary CLL cells with CLB or Flu increases the mRNA , protein and cell surface expression levels of DR 4 and DR 5 in a dose dependent manner . ^^^ In contrast to CLL cells , drug treatment fails to increase significantly the expression of DR 4 or DR 5 in normal lymphocytes . ^^^ Preventing TRAIL from interacting with DR 4 and DR 5 decreases CLB induced apoptosis in CLL cells . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Apoptosis pathways activated by death receptors of the tumour necrosis factor ( TNF ) family such as Fas , TNFR 1 , or the TRAIL receptors DR 4 and DR 5 are implicated in diverse diseases . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
HLA class 2 DR 2 , DR 4 , DR 5 , DRw 8 , DRw 10 , DRw 11 , DRw 18 , and DQw 2 had significant relative risk ratios for preeclampsia , while DQw 3 was more common in the controls . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
TRAIL is a cytokine that can induce tumor specific apoptosis through its specific death receptors ( DR 4 and DR 5 ) and p 53 has been proven to increase the expression of death receptors . ^^^ Increased expressions of DR 4 and DR 5 of NCI H 157 and DR 4 of A 549 after p 53 overexpression were confirmed by flow cytometry . p 53 or TRAIL gene transfer increased sub G 1 fraction in cell cycle analysis and inhibited the tumor growth dose dependently and the degree was potentiated by co transfer . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The comparison of subgroups of multiple sclerosis patients and healthy individuals , formed on the basis of the DRB 1 phenotype , has shown a reliable increase in the frequency of allele B in healthy individuals and the genotype A / A frequency in patients , only among DR 4 and DR 5 positive individuals . ^^^ No reliable difference was found in the MBP allele and genotype distribution between multiple sclerosis patients and healthy individuals in combined groups of ( DR 4 , DR 5 ) negative individuals , i . e . , no carriers of any phenotype except DR 4 and DR 5 were revealed . ^^^ Thus , MBP or some other nearby gene is involved in the multiple sclerosis development in Russians , predominantly ( or exclusively ) among DR 4 and DR 5 carriers . ^^^ In this case , without stratification of analyzed individuals by the MBP alleles , multiple sclerosis is reliably associated only with DR 2 ( 15 ) , but not of DR 4 and DR 5 alleles of DRB 1 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Western blot analysis also shows that the low extracellular pH enhanced TRAIL cytotoxicity does not involve modulation of the levels of TRAIL receptors ( DR 4 , DR 5 , and DcR 2 ) , FLIP , inhibitor of apoptosis ( IAP ) , and Bcl 2 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Although DR 4 , DR 5 , DcR 1 and DcR 2 can also be detected in the placenta throughout pregnancy , DR 4 and DR 5 staining increased with development whereas DcR 1 and DcR 2 staining decreased . ^^^ Interestingly , at the beginning of the gestation DR 4 and DR 5 staining distributed on the cytotrophoblast mainly , whereas DcR 1 and DcR 2 mainly located in the syncytiotrophoblast cells . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Exposure of cells to TRAIL resulted in the upregulation of both death receptors DR 4 and DR 5 and apoptosis , as well as the activation of caspase 8 and 3 , increased phosphorylation of Jun N terminal kinase and p 38 kinase , and the reduction of bcl 2 and bcl xL proteins . ^^^ Preincubation with E 17 beta completely prevented both TRAIL induced DR 4 and DR 5 upregulation and apoptosis . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
RESULTS : Ad TRAIL infection induced expression of TRAIL in RCJ3 . 1C . 18 cells , increased expression of death receptor 4 ( DR 4 ) , and decreased expression of DR 5 and decoy receptor 1 ( DcR 1 ) . ^^^ Cartilage obtained from rats with experimentally induced OA showed increased expression of TRAIL and DR 4 and decreased expression of DR 5 and DcR 1 compared with control cartilage . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
To date six bona fide death receptors ( DRs ) have been discovered and include tumor necrosis factor receptor 1 ( TNF R 1 ) , Fas , DR 3 , DR 4 , DR 5 and DR 6 . ^^^ TNF related apoptosis inducing ligand ( TRAIL ) , also known as Apo2L , activates DR 4 and DR 5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
In the present study , expression of TRAIL and its apoptosis inducing death receptors ( DR 4 and DR 5 ) and inhibitory decoy receptor ( DcR 1 ) was studied in normal ovaries and in malignant ovarian tumors before and after chemotherapy to investigate the therapeutic potential of TRAIL . ^^^ METHODS : DR 4 , DR 5 , DcR 1 , and TRAIL were studied immunohistochemically in 5 normal ovaries , 15 stages I / II , and 26 stages III / IV primary ovarian cancers , including 19 paired tumor samples ( pre and post chemotherapy ) . ^^^ Of the ovarian cancers , 73 % expressed DR 4 , 51 % DR 5 , 46 % DcR 1 , and 34 % TRAIL . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Agonistic DR 4 and DR 5 antibodies against their TRAIL death receptor are being studied as another potential clinical option to induce apoptosis . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
TRAIL is known to bind to 4 different receptors , 2 proapoptotic ( DR 4 and DR 5 ) , and 2 potentially antiapoptotic receptors lacking death domains ( DcR 1 and DcR 2 ) . ^^^ Methylation of DR 4 and DR 5 was rare in all the tumor types examined . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The combined cytotoxicity of TRAIL and EPI was significantly inhibited by the TRAIL neutralizing fusion protein DR 5 : Fc , although EPI did not affect the mRNA expression of DR 4 , DR 5 , DcR 1 or DcR 2 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Exposure to LAQ 824 increased the mRNA and protein expressions of the death receptors DR 5 and / or DR 4 , but reduced the mRNA and protein levels of cellular FLICE inhibitory protein ( c FLIP ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Enhancement of TRAIL induced apoptosis in MM cells by alpha TOS was also associated with upregulation of the TRAIL cognate death receptors DR 4 and DR 5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The DR 4 and DR 5 receptors were positive in 20 patients ( 69 % ) and 29 ( 100 % ) , respectively . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Recent studies show that death receptors ( DR 4 and DR 5 ) , decoy receptors ( DcR 1 and DcR 2 ) , and death inhibitors ( FLIP , FAP 1 , and IAP ) are responsible for the differential sensitivity to TRAIL of normal and tumor cells . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
In this study , we demonstrate for the first time that sodium butyrate selectively up regulated DR 5 but had no effect on the expression of the other TNF alpha related apoptosis inducing ligand ( TRAIL ) receptor , DR 4 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Several human death receptors ( Fas , TNF R 1 , TRAMP , DR 4 , DR 5 , DR 6 , EDA R and NGF R ) have been identified . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
No correlation was found between the sensitivity of cells to TRAIL and the expression of TRAIL receptors DR 4 and DR 5 , and pro apoptotic proteins Bax and Bak . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
In many mammalian cell types , engagement of the TRAIL / Apo2L death receptors DR 4 and DR 5 alters mitochondrial physiology , thereby promoting the release of pro apoptotic proteins normally contained within this organelle . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) signals apoptosis through two receptors , DR 4 and DR 5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
NAG 1 cDNA was transfected into SNU 601 cells , and the relation between the ectopic expression of NAG 1 and death receptor 4 ( DR 4 ) and DR 5 levels was studied . ^^^ Moreover , temporal expressions of DR 4 and DR 5 induced by sulindac sulfide were similar to that of NAG 1 . ^^^ Forced NAG 1 expression significantly induced apoptosis and DR 4 and DR 5 expression . ^^^ We conclude that NAG 1 expression is closely related to DR 4 and DR 5 induction , which could provide a mechanistic basis for the apoptotic effect of COX inhibitors in gastric cancer cells . . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
We show that both mRNA and protein of TRAIL receptors death receptors ( DR 4 , DR 5 ) and decoy receptors ( DcR 1 , DcR 2 ) are present in GCT stromal tumor cells . ^^^ This effect was in accord with our observation that TG predominantly up regulated both mRNA and protein expression of DR 5 , as well as DR 4 mRNA while down regulating DcR 1 protein in GCT stromal like tumor cells . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
We showed that the expression of death receptor DR 5 , but not DR 4 was up regulated and the decoy receptor DcR 1 was down regulated in the cells treated with 8 Cl Ado and the recombinant soluble TRAIL ( rsTRAIL , 95 281 a . a . ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Results from colocalization and immunoprecipitation studies showed that IG 20 can interact with TRAIL death receptors ( DR ) , DR 4 and DR 5 and increase recruitment of FADD and caspase 8 into the TRAIL death inducing signaling complex ( DISC ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Osteoprotegerin ( OPG ) is a survival factor that exerts its effect by binding to tumor necrosis factor ( TNF ) related apoptosis inducing ligand ( TRAIL ) , thus preventing TRAIL from binding to the apoptosis receptors DR 4 and DR 5 . ^^^ The expression of DR 4 and DR 5 in the endometriotic tissue was examined by reverse transcription polymerase chain reaction . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
TRAIL mediates its effect via death receptors 4 ( DR 4 ) and DR 5 and appears to selectively induce apoptosis in cancer cells . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Rheumatoid FLS in vitro expressed both death domain containing receptors [ death receptor 4 ( DR 4 ) and DR 5 ] and decoy receptors [ decoy receptor 1 ( DcR 1 ) and DcR 2 ] . ^^^ DR 4 expression on FLS was weak compared with the expression of DR 5 , DcR 1 and DcR 2 . ^^^ DR 5 as well as DR 4 were functional with regard to TRAIL mediated apoptosis induction in FLS ; however , DR 5 appeared be more efficient than DR 4 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Membrane expression of TRAIL receptors DR 4 ( death receptor 4 ) , DR 5 ( pro apoptotic ) , DcR 1 ( decoy receptor 1 ) , DcR 2 ( anti apoptotic ) was assessed by flow cytometry . ^^^ All cell lines expressed DR 4 and DR 5 , but hardly any DcR 1 or DcR 2 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The expression levels of DR 4 , DR 5 , DcR 1 and DcR 2 were measured in TRAIL treated and chemotherapeutic agent treated A 549 cells by Western blotting . ^^^ The expression levels of DR 4 and DR 5 were not significantly different and the expression of DcR 2 was slightly downregulated , but the expression of DcR 1 was not detected in non treated , TRAIL treated and chemotherapeutic agent treated A 549 cells . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Here , we show that malignant mesothelial ( MM ) cell lines as well as primary MM cells and normal mesothelial ( NM ) cells express Fas and TNF related apoptosis inducing ligand ( TRAIL ) receptors DR 4 and DR 5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Differential regulation of the TRAIL death receptors DR 4 and DR 5 by the signal recognition particle . ^^^ TRAIL ( TNF related apoptosis inducing ligand ) death receptors DR 4 and DR 5 facilitate the selective elimination of malignant cells through the induction of apoptosis . ^^^ From previous studies the regulation of the DR 4 and DR 5 cell death pathways appeared similar ; nevertheless in this study we screened a library of small interfering RNA ( siRNA ) for genes , which when silenced , differentially affect DR 4 vs . ^^^ These experiments revealed that expression of the signal recognition particle ( SRP ) complex is essential for apoptosis mediated by DR 4 , but not DR 5 . ^^^ The lack of severe phenotype after SRP depletion allowed us to delineate , for the first time , a mechanism for the differential regulation of the TRAIL death receptors DR 4 and DR 5 implicating the SRP complex as an essential component of the DR 4 cell death pathway . . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
TRAIL / FP induced no discernible changes in FLIP , DR 4 , DR 5 , Mcl 1 , or survivin expression , modest declines in levels of DcR 2 and c IAP , but resulted in the marked transcriptional downregulation of XIAP . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Hsp 70 was bound to death receptors 4 and 5 ( DR 4 and DR 5 ) and inhibited Apo 2L / TRAIL induced assembly and activity of the death inducing signaling complex ( DISC ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Chemotherapeutic drugs ( paclitaxel , vincristine , vinblastine , etoposide , doxorubicin , and camptothecin ) significantly augmented TRAIL induced apoptosis in cancer cells through up regulation of DR 4 , DR 5 , Bax , and Bak , and induction of caspase activation . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Pretreating the cells with neutralizing antibodies to Fas , tumor necrosis factor ( TNF ) alpha receptor 1 , or TNF related apoptosis inducing ligand receptors ( DR 4 and DR 5 ) did not affect taxol induced apoptosis , but transfection of the cells with a dominant negative FADD plasmid resulted in inhibition of taxol induced apoptosis , revealing that taxol induces apoptosis independently of these death receptors but dependently on FADD . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Members of the tumor necrosis factor ( TNF ) superfamily of receptors such as Fas / CD95 and the TNF related apoptosis inducing ligand ( TRAIL ) receptors DR 4 and DR 5 induce apoptosis by recruiting adaptor molecules and caspases . ^^^ Here , we show that in addition to the death domain , the C terminal tails of DR 4 and DR 5 positively regulate FADD binding , caspase activation and apoptosis . ^^^ These data demonstrate that regions outside the death domains of DR 4 and DR 5 have opposite effects to that of Fas in regulating FADD recruitment and show that different death receptor agonists can use distinct molecular mechanisms to activate signaling from the same receptor . . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Redistribution of CD 95 , DR 4 and DR 5 in rafts accounts for the synergistic toxicity of resveratrol and death receptor ligands in colon carcinoma cells . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) related apoptosis inducing ligand ( TRAIL ) is a member of the TNF family of cytokines , which can induce apoptotic cell death in a variety of tumor cells by engaging the death receptors DR 4 and DR 5 , while sparing most normal cells . ^^^ Preclinical studies in mice and non human primates have shown the potential utility of recombinant soluble TRAIL and agonistic anti DR 5 or DR 4 antibodies for cancer therapy . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Western blotting analyses revealed that IFN gamma dramatically increased the protein levels of interferon regulatory factor ( IRF ) 1 , but not TRAIL receptors ( DR 4 and DR 5 ) and pro apoptotic ( FADD and Bax ) and anti apoptotic factors ( Bcl 2 , Bcl XL , cIAP 1 , cIAP 2 and XIAP ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Apo2L / TRAIL is a homotrimeric protein that interacts with five receptors : death receptor 4 ( DR 4 ) and DR 5 mediate apoptosis activation , whereas decoy receptor 1 ( DcR 1 ) , DcR 2 , and osteoprotegerin counteract this function . ^^^ Many cancer cell lines express both DR 4 and DR 5 , and each of these receptors can initiate apoptosis independently of the other . ^^^ However , the relative contribution of DR 4 and DR 5 to ligand induced apoptosis is unknown . ^^^ Selective binding to DR 4 or DR 5 was achieved with three to six ligand amino acid substitutions . ^^^ The DR 4 selective Apo2L / TRAIL variants examined in this study showed a markedly reduced ability to trigger apoptosis , whereas the DR 5 selective variants had minimally decreased or slightly increased apoptosis inducing activity . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Frequent polymorphic changes but not mutations of TRAIL receptors DR 4 and DR 5 in mantle cell lymphoma and other B cell lymphoid neoplasms . ^^^ BACKGROUND AND OBJECTIVES : Tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) receptors DR 4 and DR 5 have been mapped to chromosome 8p21 22 , a region frequently deleted in different lymphoid neoplasms . ^^^ INTERPRETATION AND CONCLUSIONS : These findings indicate that mutations of DR 4 and DR 5 are uncommon in lymphoid neoplasms but DR 4 polymorphic alleles may contribute to the pathogenesis of these malignancies . . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
In conflict with the presence of active DR 4 and DR 5 receptors in both clones , U2OS cells exhibited only a low responsiveness to TRAIL , while the MDR U2OS subline did exhibit a marked TRAIL sensitivity . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Dysfunctions of the death receptors DR 4 and DR 5 due to mutations can lead to resistance . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
To investigate the role of TRAIL mediated apoptosis , AGS cells were transduced with antisense constructs against the proapoptotic TRAIL receptors DR 4 and DR 5 . ^^^ Protein expression of Fas , TRAIL , DR 4 , and DR 5 was analyzed by Western blot . ^^^ In the presence of H . pylori , TRAIL ligand and DR 5 receptor were continuously expressed whereas DR 4 expression was increasing time dependently . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
We first isolated human hepatocytes from patients and showed that the human hepatocytes expressed Fas but no TRAIL death receptor DR 4 and little DR 5 on the cell surface . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Expression levels of TRAIL death ( DR 4 and DR 5 ) and decoy ( DcR 1 and DcR 2 ) receptors were not different between primary and metastatic OC cells . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
TRAIL signals through its receptors DR 4 and DR 5 , which can activate caspase 8 as well . ^^^ METHODS : The human Rb cell lines Y 79 and WERI Rb 1 were evaluated for their response to the Fas cross linking antibody CH 11 and recombinant TRAIL , as well as for cell surface presence and mutational status of Fas , DR 4 , and DR 5 by flow cytometry and genomic DNA sequencing , respectively . ^^^ RESULTS : Rb cells express Fas , DR 4 , and DR 5 on their surfaces , yet were resistant to DR mediated apoptosis . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
LLnL significantly induced the Apo2L receptors DR 4 and DR 5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Here , we show that caspase 8 activity is significantly increased , whereas the expression of death receptors other than Fas , including the type 1 receptor for tumor necrosis factor alpha ( TNF alpha ) and the receptors for the TNF related apoptosis inducing ligand ( TRAIL ) , DR 4 and DR 5 , was normal . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
RESULTS : The frequency of HLA DR 4 , but not DR 9 , was significantly higher in fulminant type 1 diabetes , while those of HLA DR 1 , DR 2 , DR 5 and DR 8 were significantly lower than those in controls . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
In normal cervix and CIN 1 samples , FasL , DR 4 , DR 5 , and TRAIL staining was mainly observed in the basal / parabasal layer , whereas Fas staining was localized in the superficial , more differentiated epithelial layer . ^^^ In contrast , homogeneous FasL , DR 4 , DR 5 , and TRAIL expression throughout the lesions was more frequently observed in CIN 3 and cervical cancer . ^^^ FasL , DR 4 , DR 5 , and TRAIL staining patterns were correlated , although TRAIL expression was more intense in low grade lesions . ^^^ CONCLUSION : The loss of Fas and the deregulation of FasL , DR 4 , DR 5 , and TRAIL in the CIN cervical cancer sequence suggest a possible functional role of these death ligands and receptors during cervical carcinogenesis . ^^^ The frequent expression of DR 4 and DR 5 presents these receptors as promising targets for innovative therapy modalities in cervical cancer . . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The mRNAs of death receptors 4 and 5 ( DR 4 and DR 5 ) were induced in leukemia cells undergoing apoptosis after boswellic acid acetate treatment . ^^^ These data taken together suggest that boswellic acid acetate induces myeloid leukemia cell apoptosis through activation of caspase 8 by induced expression of DR 4 and DR 5 , and that the activated caspase 8 either directly activates caspase 3 by cleavage or indirectly by cleaving Bid , which in turn decreases mitochondria membrane potential . . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Epigenetic analysis of HIC 1 , CASP 8 , FLIP , TSP 1 , DCR 1 , DCR 2 , DR 4 , DR 5 , KvDMR 1 , H 19 and preferential 11p15 . 5 maternal allele loss in von Hippel Lindau and sporadic phaeochromocytomas . ^^^ Of four tumour necrosis factor related apoptosis inducing ligand ( TRAIL ) receptors analysed , DR 4 was most commonly methylated ( 41 % ; compared with DcR 2 ( 26 % ) , DcR 1 ( 23 % ) and DR 5 ( 10 % ) ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) acts through the pro apoptotic DR 4 and DR 5 receptors in tumor cells without harming normal cells and will soon be tested in clinical trials as a novel anti cancer agent . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
IFN gamma pretreatment significantly suppressed the expression of death receptor 4 ( DR 4 ) and DR 5 on HUVECs , and inhibited apoptosis in response to TRAIL . ^^^ IFN gamma / JAK / STAT pathway induced inhibition of DR 4 and DR 5 expression on endothelial cells is cancelled by cycloheximide sensitive mechanism : novel finding of cycloheximide regulating death receptor expression . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
To address this issue , the extracellular domains ( ECDs ) of DR 4 ( sDR 4 ) , DR 5 ( sDR 5 ) , DcR 1 ( sDcR 1 ) , and DcR 2 ( sDcR 2 ) were expressed in a soluble , monomeric form , and their binding interactions were quantified by surface plasmon resonance . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The selective tumoricidal activity of TRAIL is believed to be modulated by agonistic ( DR 4 and DR 5 ) and antagonistic receptors ( DcR 1 and DcR 2 ) , which appear to compete for ligand binding . ^^^ Reverse transcriptase polymerase chain reaction ( RTPCR ) was performed to study expression of DR 4 , DR 5 , DcR 1 , and DcR 2 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
From a mechanistic standpoint , we show that CDDO and CDDO Im down regulate the antiapoptotic protein c FLIP ( L ) , and up regulate cell surface TRAIL receptors DR 4 and DR 5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Whereas exposure to 3 Cl AHPC results in NF kappaB activation , it inhibits the expression of XIAP , c IAP 1 , and Bcl 10 ( L ) and enhances the expression of proapoptotic molecules , including the death receptors DR 4 and DR 5 as well as Fas and Rip 1 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The results showed death receptor 4 ( DR 4 ) and DR 5 were expressed in 60 HCC tissues and 20 normal liver samples , while the expression intensity of DR in HCC tissues was stronger than in normal liver samples . ^^^ The expression of DR 5 , DR 4 and DcR 2 in both HCC cell lines was detectable , but the expression of DcR 1 was not detectable . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
LY 294002 increased Hep3B cell susceptibility to chemotherapy induced apoptosis by enhancing the expression of DR 4 and DR 5 and the activation of caspase 8 and 3 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The expression of TRAIL receptors ( DR 4 , DR 5 , DcR 1 , and DcR 2 ) and the expression of death signal transducing proteins were investigated . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Low doses of SAHA or TSA enhanced the cytotoxic and apoptotic effects of TRAIL and upregulated the surface expression of TRAIL death receptors ( DR 4 and / or DR 5 ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Apoptosis was assessed by M 30 staining and expression patterns of DR 4 , DR 5 , beta catenin , and p 21 were studied immunohistochemically . ^^^ Expression of DR 4 and DR 5 was observed in all samples with no consistent differences between placebo / baseline and sulindac . ^^^ In conclusion , sulindac inhibits beta catenin expression in normal colorectal epithelium from HNPCC and FAP patients without affecting apoptotic indices and DR 4 , DR 5 , and p 21 expression . . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) induces apoptosis via the death receptors DR 4 and DR 5 in transformed cells in vitro and exhibits potent antitumor activity in vivo with minor side effects . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Western blot analysis showed that combined treatment with TRAIL and amiloride did not change the levels of TRAIL receptors ( DR 4 , DR 5 , and DcR 2 ) and anti apoptotic proteins ( FLIP , IAP , and Bcl 2 ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
In the present study , expressions of TRAIL receptors , death receptor 4 ( DR 4 ) and DR 5 , were detected in all ameloblastoma tissues by immunohistochemistry as well as in AM 1 cells by immunofluorescence . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Immunohistochemistry was performed for cell cycle regulators [ p 53 , p 21 , p 27 , p 16 , cyclin D 1 , Rb ] , apoptosis related proteins [ Fas , Fas L , FADD , TRAIL , DR 4 , DR 5 , caspase 8 , caspase 3 , bcl 2 , Bax ] , tumor suppressor proteins [ beta catenin , E cadherin , FHIT , Smad 4 , VHL , PTEN , KAI 1 ] , and oncoproteins [ c myc , COX 2 , EGFR ] . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Here , we have generated and characterised a set of monoclonal antibodies , together with mAbs from the HLDA workshop , against DcR 1 , DcR 2 , DR 4 , DR 5 , TRAIL , APRIL , BAFF , BAFF R , BCMA , and TACI , which may be useful in phenotypic and functional studies of the role of TNF and TNF receptor family in immune function and regulation in relation to health and disease . . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The cytokine TRAIL ( tumor necrosis factor alpha related apoptosis inducing ligand ) as well as agonistic antibodies that bind to the TRAIL receptors , death receptor 4 ( DR 4 ) and DR 5 , are undergoing preclinical and early clinical evaluation as potential therapeutic agents for a variety of hematological and nonhematological malignancies . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Some members of the DR family , CD 95 and the TRAIL receptors DR 4 and DR 5 , directly bind FADD , whereas others , such as TNF receptor 1 and DR 3 , initially bind another adaptor protein , TRADD , which then recruits FADD . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Given that sulindac sulfide activated caspase 8 and increased membrane death receptor ( DR 4 and DR 5 ) protein levels , we evaluated its combination with the endogenous death receptor ligand tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The recruitment of the p 53 dependent apoptosis pathway was suggested by the up regulation of p 53 , p 21 , Bax , DR 4 , DR 5 , and p 53 phosphorylated on Ser 15 ; down regulation of Bcl 2 ; and activation of caspase 8 , 9 , 7 , and 3 in cells treated with 100 nmol / L WMC 79 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Its expression , like the other three TRAIL receptors ( i . e . , DR 4 , DR 5 , and DcR 1 ) , is regulated by p 53 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
No changes were observed in DR 4 , DR 5 , DcR 1 , and TRAIL mRNA and protein levels in prostate after castration . ( 2 ) A specific decrease in DcR 2 expression was observed in the ventral prostate after treatment of rats with the anti androgen flutamide . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
OBJECTIVES : There is substantial evidence that tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) causes apoptosis via activation of death receptors 4 and 5 ( DR 4 and DR 5 ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Two of them , death receptors 4 and 5 ( DR 4 and DR 5 ) , induce apoptosis , whereas decoy receptors 1 and 2 ( DcR 1 and DcR 2 ) are unable to evoke cell death upon TRAIL binding . ^^^ We observed frequent expression of TRAIL DcR 1 and DcR 2 , while expression of DR 4 and DR 5 was less frequent . ^^^ Nevertheless , the expression of DR 4 or DR 5 in leukaemic cells was always matched by a similar expression of one of the decoy receptors . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
HDAC inhibitors enhance the apoptosis inducing potential of TRAIL in leukemia cells ( HL 60 , Jurkat , K 562 , and U 937 ) through multiple mechanisms ; up regulation of DR 4 , DR 5 , Bak , Bax , Bim , Noxa and PUMA , down regulation of IAPs , Mcl 1 , Bcl 2 , Bcl XL and cFLIP , release of mitochondrial proteins ( cytochrome c , Smac / DIABLO and Omi / Htr2 ) to the cytosol , induction of p21WAF1 / CIP1 and p27KIP1 , activation of caspase 3 and cleavage of poly ( ADP ribose ) polymerase ( PARP ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
MG 132 massively induced TRAIL receptor DR 4 and DR 5 membrane expression in HeLa , whereas in SiHa only DR 5 membrane expression was upregulated from almost undetectable to high levels . ^^^ Our results indicate that not only DR 4 and DR 5 upregulation but also XIAP inactivation contribute to rhTRAIL sensitization by MG 132 in cervical cancer cell lines . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
For evaluating melanoma susceptibility , we studied the functionality of DR 4 and DR 5 in melanoma cells as well as their expression in vivo . ^^^ DR 5 was consistently expressed in melanoma cell lines , whereas DR 4 was found in only 2 / 7 cell lines . ^^^ The significance of these data for the in vivo situation was finally evaluated by immunohistochemistry , which proved pronounced expression of DR 4 as well as of DR 5 in melanoma primary tumors . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Further results demonstrated that E1A specifically upregulated DR 5 levels but had nearly no effect on the levels of DR 4 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Perturbation of the tumor necrosis factor related apoptosis inducing ligand cascade in ovarian cancer : overexpression of FLIPL and deregulation of the functional receptors DR 4 and DR 5 . ^^^ EXPERIMENTAL DESIGN : We used an arrayed panel of epithelial ovarian cancer tissue to assess the protein expression of TRAIL and the clinically most relevant members of its pathway death receptors 4 and 5 ( DR 4 and DR 5 ) and the long form of FLICE inhibitory protein ( FLIPL ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
In cancer patients , phase 1 and 2 clinical trials using agonistic mAbs that engage the human TRAIL receptors DR 4 and DR 5 have also provided encouraging results . ^^^ It is now evident that TRAIL suppresses autoimmune disease in various experimental animal models , suggesting that the therapeutic value of recombinant TRAIL and agonistic DR 4 and DR 5 mAbs might also extend to the suppression of autoimmune disease . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
TSA induced the transcription of TRAIL death receptor DR 5 without affecting the transcription of DR 4 and the decoy receptors ; DcR 1 and DcR 2 . ^^^ However , the surface expression of both DR 4 and DR 5 was not modulated by TSA treatment . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
In PLB 985 , but not WY 1 cells , RA induced TRAIL and its DR 4 and DR 5 receptors . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The synergistic effect is not associated with DR 4 , DR 5 , FADD , and FLIP ( L ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Alpha tocopheryl succinate induces DR 4 and DR 5 expression by a p 53 dependent route : implication for sensitisation of resistant cancer cells to TRAIL apoptosis . ^^^ MM cells selected for TRAIL resistance expressed low cell surface levels of DR 4 and DR 5 . ^^^ Treatment with sub lethal doses of alpha TOS restored expression of DR 4 and DR 5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
BACKGROUND : As advanced prostate cancers are resistant to currently available chemotherapies , we evaluated the cytotoxic effect of TNF related apoptosis inducing ligand ( TRAIL ) and characterized the involvement of its five receptors DR 4 , DR 5 , DcR 1 , DcR 2 , and osteoprotegerin ( OPG ) and of the death inducing signaling complex ( DISC ) forming proteins caspase 8 and c FLIP in prostate cell lines . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Treatment with SAHA increased cell surface expression of DR 5 but not DR 4 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
TRAIL death receptors ( DR 4 , DR 5 ) are weakly expressed at mRNA , protein , and cell surface levels and thus fail to mediate the assembly of the DISC in human astrocytes . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
We also searched the homologous human and microbial sequences for peptide binding motifs of HLA DR molecules , because a number of these class 2 major histocompatibility complex ( MHC ) molecules ( DR 3 , DR 4 , DR 5 , DR 8 , and DR 9 ) are associated with AITD . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
No heat mediated alteration in the antibody recognition of cell surface DR 4 and DR 5 TRAIL receptors was observed . ^^^ However , in the presence of TRAIL , a long lasting attenuation in the antibody detection of DR 4 and DR 5 was observed in heat shock treated cells that correlated with the enhanced apoptogenic efficiency of TRAIL . . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
RESULTS : CGH detected loss of the chromosomal regions that contain the following genes : 8p12 p 23 ( DR 4 and DR 5 ) , 2q33 34 ( caspase 8 ) , 11q13 . 3 ( FADD ) , 22q11 . 2 ( Bid ) , and 12q24 . 1 q24 . 3 ( Smac / DIABLO ) in TRAIL resistant cell lines . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
SNU 668 cells with ectopic expression of NAG 1 showed markedly elevated subG 1 population , induced death receptor 4 ( DR 4 ) and DR 5 , and revealed smaller active fragments of caspase 3 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
These inhibitors cause the accumulation of many proteins in the cell with the induction of apoptosis including TRAIL death receptors DR 4 and DR 5 , but the role of the TRAIL apoptotic pathway in proteasome inhibitor cytotoxicity is unknown . ^^^ Herein , we have demonstrated that the induction of apoptosis by the proteasome inhibitors , MG 132 and PS 341 ( bortezomib , Velcade ) , in primary CLL cells and the Burkitt lymphoma cell line , BJAB , is associated with up regulation of TRAIL and its death receptors , DR 4 and DR 5 . ^^^ Moreover , DR 4 : Fc or blockage of DR 4 and DR 5 expression using RNA interference , which prevents TRAIL apoptotic signaling , blocks proteasome inhibitor induced apoptosis . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) is a potential anticancer drug that selectively induces apoptosis in a variety of cancer cells by interacting with death receptors DR 4 and DR 5 . ^^^ These variants do not induce apoptosis in DR 4 responsive cell lines but show a large increase in biological activity in DR 5 responsive cancer cell lines . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Sensitization to Apo2L / TRAIL mediated by cardiac glycosides was accompanied by up regulation of death receptors 4 ( DR 4 ) and 5 ( DR 5 ) on both RNA and protein levels . ^^^ Blocking of up regulation of DR 4 and DR 5 alone significantly reduced cell death after combined treatment with cardiac glycosides and Apo2L / TRAIL . ^^^ Combined silencing of DR 4 and DR 5 abrogated the ability of cardiac glycosides and Apo2L / TRAIL to induce apoptosis in an additive manner . ^^^ To our knowledge , this is the first demonstration that glycosides up regulate DR 4 and DR 5 , thereby reverting the resistance of lung cancer cells to Apo2 / TRAIL induced apoptosis . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
DR 5 but not DR 4 engagement by TRAIL attenuated cellular ATP levels by robustly stimulating P gp ATPase activity , and thus triggered P gp dependent apoptosis by depletion of the cellular ATP pool . ^^^ P gp interacted with the TRAIL receptors DR 4 , DR 5 , and DcR 1 in plasma membranes and enhanced TRAIL binding to DR 5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Tumors sensitized to NK cell cytotoxicity showed a significant increase in surface expression of DR 5 [ tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) R 2 ; P < 0 . 05 ] ; in contrast , surface expression of MHC class 1 , MIC A / B , DR 4 ( TRAIL R 1 ) , and Fas ( CD 95 ) did not change . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
In one case , the level of the cell surface death receptor DR 4 , but not DR 5 , was significantly decreased . ^^^ However , these cells did undergo apoptosis in response to another form of recombinant TRAIL , histidine tagged TRAIL , suggesting differing contributions of DR 4 and DR 5 in the response to these two forms of TRAIL . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) has been shown to induce apoptosis in prostate cancer cells through DR 4 and DR 5 death receptors , but not in normal prostate cells , which do not express these receptors . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Apo2L / TRAIL ligation of specific cell surface receptors ( DR 4 and DR 5 ) induces apoptosis of many malignant cells with little effect on normal cells . ^^^ Currently , the clinical potential of several molecules targeting the Apo2L / TRAIL receptors DR 4 and DR 5 is being investigated . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
A link was registered between lethality rate , on the one hand , and HLA A 3 , B 22 , and , in particular , DR 4 , on the other , while remission of more than 7 years with HLA A 11 , B 13 , B 21 and DR 5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Therefore , the prognostic relevance was analyzed of the expression of TRAIL and its death receptors DR 4 and DR 5 on disease free survival and overall survival in stage 3 colon cancer patients treated with adjuvant chemotherapy . ^^^ METHODS : Tissue microarrays were constructed of primary tumor tissue from 376 stage 3 colon cancer patients treated in a randomized adjuvant chemotherapy study ( fluorouracil / levamisole 5 fluorouracil / levamisole / leucovorin ) and stained immunohistochemically for TRAIL , DR 4 , and DR 5 . ^^^ RESULTS : The majority of tumors showed high expression of TRAIL ( 83 % ) , DR 4 ( 92 % ) , and DR 5 ( 87 % ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The combination of an antibody against DR 4 with doxorubicin : a selective killer of prostate cancers . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
KILLER / DR5 gene encodes a DR containing cell surface protein that is highly homologous to DR 4 , another DR of the tumor necrosis factor ( TNF ) receptor family . ^^^ Both DR 4 and KILLER / DR5 independently bind to their specific ligand TRAIL and engage the caspase cascade to induce apoptosis . ^^^ TRID ( also known as TRAIL R 3 ) is an antiapoptotic decoy receptor that lacks the cytoplasmic death domain and competes with KILLER / DR5 and DR 4 for binding to TRAIL . ^^^ Unlike KILLER / DR5 , none of the other KILLER / DR5 family members , including DR 4 , TRID , or the ligand TRAIL , displayed genotoxic stress or TNF alpha regulation in a p 53 transcription dependent manner . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
MK is highly homologous and binds TRAIL with similar affinity as human DR 4 and KILLER / DR5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
TRAIL binds to the proapoptotic death receptors DR 4 and the p 53 regulated proapoptotic KILLER / DR5 as well as to the decoy receptors TRID and TRUNDD . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The family of tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) receptors , including the pro apoptotic DR 4 and p 53 regulated KILLER / DR5 , as well as the decoys TRID and TRUNDD , are all located on human chromosome 8p21 22 . ^^^ In addition , there appears to be a homozygous deletion involving DR 4 but not KILLER / DR5 in FaDu cells . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
While further evaluation of the role of TRAIL receptors in human cancer is ongoing , initial studies suggest that both KILLER / DR5 and DR 4 may be targets for inactivation and that these pro apooptotic receptors may be tumor suppressor genes . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Furthermore both c FLIP ( S ) and Bcl XL protected against overexpression of the TRAIL receptors DR 4 and KILLER / DR5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Moreover , exogenous DR 4 and KILLER / DR5 were not properly transported to the cell surface in the TRAIL resistant cells . ^^^ Interestingly , TRAIL resistant cells were resensitized to TRAIL by tunicamycin pretreatment , which increased cell surface expression of DR 4 and KILLER / DR5 . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) receptors , including TNFRSF10A and TNFRSF10B , are located within this chromosomal region . ^^^ In this study we analyzed the complete coding region of TNFRSF10A and TNFRSF10B in a series of 32 MCL and 101 CLL samples and detected a single nucleotide polymorphism ( SNP ) in TNFRSF10A ( A683C ) with tumor specific allele distribution . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Using a soluble molecule containing the TRICK 2 extracellular domain , we demonstrated that TRICK 2 , like DR 4 [ 1 ] , is a receptor for TRAIL / APO 2L [ 2 , 3 ] and could inhibit TRAIL induced killing of lymphocyte lines , such as the Jurkat T cell line . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
These include Fas , TNF R 1 , lymphocyte associated receptor of death ( LARD ) , DR 4 , and TNF related apoptosis inducing ligand receptor inducer of cell killing 2 ( TRICK 2 ) . ^^^ This is a particular problem for lymphocytes that express DR 4 and TRICK 2 and are in constant circulation through TRAIL expressing tissues . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
MATERIAL / METHODS : To test this hypothesis , we estimated by FACS analysis the turnover rates of receptors for TRAIL ( TRAILR 1 and TRAILR 2 ) , signal regulatory protein SIRPa , receptor for alpha / beta interferon ( INFR 1 ) , and poliovirus receptor ( CD 155 ) on the surface of HeLa cells after the treatment with brefeldin A ( to stop receptor replenishment through the Golgi mediated trafficking ) or poliovirus infection . ^^^ RESULTS : A good correlation between turnover rates caused by the two interventions was observed , with the stability of receptor presentation changing in the following order : TRAILR 1 , TRAILR 2 , SIRPa ( half life on infected cells between 2 4 h ) < INFR 1 ( 4 6 h ) < CD 155 ( > 8 h , besides some early masking of the receptor by its binding of the virus ) . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
Expression of TRAILR 1 and TRAILR 2 in human cardiomyocytes was confirmed immunohistochemically . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
The membrane bound death ligands CD95L / FasL and TRAIL , which activate the corresponding death receptors CD95 / Fas , TRAILR 1 and TRAILR 2 , induce apoptosis in many tumour cells , but can also elicit an inflammatory response . ^^^
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
NA
Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
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Interacting proteins: O14763 and O00220	Pubmed	SVM Score :0.0
NA