| Interacting proteins: O14735 and P14672 |
Pubmed |
SVM Score :0.0 |
| LD syndrome appears to be induced by PIs that inhibit GLUT 4 , glucose transporter isoform , and by NRTIs which provoke mitochondrial failure . ^^^ |
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| Interacting proteins: O14735 and P14672 |
Pubmed |
SVM Score :0.0 |
| PIs have recently been found to cause acute and reversible inhibition of GLUT 4 activity in vitro . ^^^ These data demonstrate that indinavir causes acute and reversible changes in whole body glucose homeostasis in rats and support the contribution of GLUT 4 inhibition to the development of insulin resistance in patients treated with PIs . . ^^^ |
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| Interacting proteins: O14735 and P14672 |
Pubmed |
SVM Score :0.0 |
| HIV protease inhibitors ( PIs ) acutely and reversibly inhibit the insulin responsive glucose transporter Glut 4 , leading to peripheral insulin resistance and impaired glucose tolerance . ^^^ |
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| Interacting proteins: O14735 and P14672 |
Pubmed |
SVM Score :0.0 |
| Over the last several years , PIs emerged as key membrane localized signals for regulating a myriad of cellular processes , including insulin induced membrane receptor signaling , GLUT 4 membrane trafficking and the accompanying actin cytoskeletal rearrangement . ^^^ Here 1 review our current understanding of the role for PIs and the enzymes involved in their turnover in the regulation of GLUT 4 membrane dynamics in response to insulin , endothelin 1 and hyperosmotic shock . . ^^^ |
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| Interacting proteins: O14735 and P14672 |
Pubmed |
SVM Score :0.0 |
| In 3T3 L 1 adipocytes , microinjected PtdIns 5 P , but not other PIs , partially mimicked insulin ' s effect of translocating enhanced green fluorescent protein GLUT 4 to the cell surface . ^^^ |
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| Interacting proteins: O14735 and P14672 |
Pubmed |
SVM Score :0.0 |
| Human immunodeficiency virus ( HIV ) protease inhibitors ( PIs ) act as reversible noncompetitive inhibitors of GLUT 4 with binding affinities in the low micromolar range and are known to contribute to alterations in glucose homeostasis during treatment of HIV infection . ^^^ To determine the molecular basis for GLUT 4 inhibition , a family of related oligopeptides containing structural elements found in PIs was screened for their ability to inhibit 2 deoxyglucose transport in primary rat adipocytes . ^^^ These data establish a structural basis for PI effects on GLUT 4 activity and support the direct binding of PIs to the transport protein as the mechanism for acute inhibition of insulin stimulated glucose uptake . . ^^^ |
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| Interacting proteins: O14735 and P14672 |
Pubmed |
SVM Score :0.0 |
| Specific protease inhibitors ( PIs ) have been associated with decreased GLUT 4 mediated glucose transport and insulin resistance both in vitro and in vivo , whereas newer protease inhibitors may have fewer effects on insulin sensitivity . ^^^ |
|
| Interacting proteins: O14735 and P14672 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14735 and P14672 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14735 and P14672 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14735 and P14672 |
Pubmed |
SVM Score :0.0 |
| NA |
|