| Interacting proteins: O15155 and O14653 |
Pubmed |
SVM Score :0.0 |
| BOS 1 and BET 1 are required for transport from the ER to the Golgi complex in yeast and genetically interact with each other and a subset of the other genes , whose products function at this stage of the secretory pathway . ^^^ |
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| Interacting proteins: O15155 and O14653 |
Pubmed |
SVM Score :0.0 |
| An analysis of BET 1 , BET 2 , and BOS 1 . ^^^ |
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| Interacting proteins: O15155 and O14653 |
Pubmed |
SVM Score :0.0 |
| BOS 1 is a gene that in multiple copy suppresses the growth and secretion defect of bet 1 and sec 22 , two mutants that disrupt transport from the ER to the Golgi complex in yeast . ^^^ Thus , Bos 1 appears to be a membrane protein that functions in conjunction with Bet 1 and Sec 22 to facilitate the transport of proteins at a step subsequent to translocation into the ER but before entry into the Golgi apparatus . . ^^^ |
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| Interacting proteins: O15155 and O14653 |
Pubmed |
SVM Score :0.0 |
| BET 1 , BOS 1 , and SEC 22 are members of a group of interacting yeast genes required for transport from the endoplasmic reticulum to the Golgi complex . ^^^ Cell Biol . 105 : 1587 1594 , 1987 ) , we isolated BET 1 and BOS 1 ( bet one suppressor ) . ^^^ BOS 1 suppresses bet 1 1 in a gene dosage dependent manner , providing greater suppression when it is introduced on a multicopy vector than when one additional copy is present . ^^^ The BET 1 and BOS 1 genes are not functionally equivalent ; overproduction of BOS 1 does not alleviate the lethality associated with disruption of BET 1 . ^^^ Overproduction of either BET 1 or BOS 1 suppresses the growth and secretory defects of the sec 22 3 mutant over a wide range of temperatures . ^^^ |
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| Interacting proteins: O15155 and O14653 |
Pubmed |
SVM Score :0.0 |
| Genetic interactions connect sec 27 1 and sec 21 1 ( coatomer gamma subunit ) with the ARF 1 and ARF 2 genes and with the SEC 22 , BET 1 , and BOS 1 genes , which encode membrane proteins involved in ER to Golgi transport . . ^^^ |
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| Interacting proteins: O15155 and O14653 |
Pubmed |
SVM Score :0.0 |
| These vesicles , which form de novo during in vitro incubations , carry lumenal and membrane proteins that include core glycosylated pro alpha factor , Bet 1 , Sec 22 , and Bos 1 , but not ER resident Kar 2 or Sec 61 proteins . ^^^ Quantitative Western blot analysis indicates that protein markers of cytosol and cellular membranes are depleted throughout the purification , whereas the synaptobrevin like Bet 1 , Sec 22 , and Bos 1 proteins are highly enriched . ^^^ |
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| Interacting proteins: O15155 and O14653 |
Pubmed |
SVM Score :0.0 |
| BOS 1 encodes an integral endoplasmic reticulum ( ER ) membrane protein and genetically interacts with three other yeast genes ( BET 1 , SEC 22 , and YPT 1 ) whose products are required for membrane traffic between the ER and the Golgi apparatus . ^^^ |
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| Interacting proteins: O15155 and O14653 |
Pubmed |
SVM Score :0.0 |
| The glo3Delta and gcs1Delta single mutations each interact with a sec 21 mutation that affects a component of COPI , which mediates vesicular transport within the ER Golgi shuttle , while increased dosage of the BET 1 , BOS 1 and SEC 22 genes encoding members of a 5 SNARE family that functions within the ER Golgi alleviates the effects of a glo3Delta mutation . ^^^ |
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| Interacting proteins: O15155 and O14653 |
Pubmed |
SVM Score :0.0 |
| To determine in which membranes protein function is required , temperature sensitive alleles of BOS 1 , BET 1 , SED 5 , SLY 1 , and YPT 1 that prevent ER / Golgi transport in vitro at restrictive temperatures were used to selectively inactivate these gene products on vesicles or on Golgi membranes . ^^^ |
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| Interacting proteins: O15155 and O14653 |
Pubmed |
SVM Score :0.0 |
| In yeast , four integral membrane proteins , Sed 5 , Bos 1 , Sec 22 and Bet 1 ( refs 2 6 ) , each probably contribute a single helix to form the SNARE complex that is needed for transport from endoplasmic reticulum to Golgi . ^^^ Fusion only occurs when the 5 SNARE Bet 1 is on one membrane and the syntaxin heavy chain Sed 5 and its two light chains , Bos 1 and Sec 22 , are on the other membrane where they form a functional t SNARE . ^^^ |
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| Interacting proteins: O15155 and O14653 |
Pubmed |
SVM Score :0.0 |
| This contrasts with a second distinct SNARE complex , also required for intra Golgi transport , consisting of syntaxin 5 ( Sed 5 ) membrin ( Bos 1 ) ERS 24 ( Sec 22 ) rBet 1 ( Bet 1 ) , whose 5 ( rBet 1 ) and t SNARE subunits ( membrin and ERS 24 ) , progressively decrease in concentration toward the trans face . ^^^ |
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| Interacting proteins: O15155 and O14653 |
Pubmed |
SVM Score :0.0 |
| NA |
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