| Interacting proteins: O14641 and O15169 |
Pubmed |
SVM Score :0.92887499 |
| The association of Axin with Dvl 2 may be important in the transmission of Wnt signals from Dvl 2 to GSK 3beta . . 0.92887499^^^ |
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| Interacting proteins: O14641 and O15169 |
Pubmed |
SVM Score :0.0 |
| We found that in contrast to Axin , Dvl 2 activation of JNK does not require MEKK 1 , and complex formation between Dvl 2 and Axin is independent of Axin MEKK 1 binding . ^^^ Furthermore , Dvl 2 DIX and Dvl 2 DeltaDEP proteins deficient for JNK activation can attenuate Axin activated JNK activity by disrupting Axin dimerization . ^^^ However , Axin DeltaMID , Axin DeltaC , and Axin CT proteins deficient for JNK activation can not interfere with Dvl 2 activated JNK activity . ^^^ These results indicate that unlike the strict requirement of homodimerization for Axin function , Dvl 2 can activate JNK either as a monomer or homodimer / heterodimer . ^^^ |
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| Interacting proteins: O14641 and O15169 |
Pubmed |
SVM Score :0.0 |
| Here , we show that two activators of the canonical Wnt / beta catenin transcription pathway , namely Dvl 2 , the Axin 501 560 fragment binding glycogen synthase kinase 3beta ( GSK 3beta ) , and the negative Wnt regulator wt Axin did not alter cell invasion into type 1 collagen . ^^^ In addition , both Dvl 2 and Axin 501 560 exerted a permissive action on the proinvasive activity of HGF and intestinal trefoil factor . ^^^ |
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| Interacting proteins: O14641 and O15169 |
Pubmed |
SVM Score :0.0 |
| The same is true for the DIX domain of Dvl 2 itself and also for Axin GFP , which equilibrates between the punctate and cytosolic pools . ^^^ Our evidence indicates that Dvl 2 and Axin puncta are dynamic protein assemblies rather than cytoplasmic vesicles . . ^^^ |
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