| Interacting proteins: O14641 and O14640 |
Pubmed |
SVM Score :0.0 |
| The Dvl 2 amino acid sequence is equally related to the dsh sequence as is that of Dvl 1 , but Dvl 2 is most similar to the Xenopus homolog Xdsh . ^^^ |
|
| Interacting proteins: O14641 and O14640 |
Pubmed |
SVM Score :0.0 |
| The predicted amino acid sequence shares 64 and 62 % identity to Dvl 1 and Dvl 2 , respectively . ^^^ |
|
| Interacting proteins: O14641 and O14640 |
Pubmed |
SVM Score :0.0 |
| We report here that the mouse Dishevelled 1 ( Dvl 1 ) and Dishevelled 2 genes encode proteins that are differentially localized in Wnt overexpressing PC 12 cell lines ( PC12 / Wnt ) . ^^^ Whereas Dvl 1 and Dvl 2 proteins are limited to the soluble fraction of parental PC 12 cells , PC12 / Wnt cells display a subset of Dvl 1 protein associated with the membrane and Dvl 2 protein with the cytoskeletal fraction . ^^^ |
|
| Interacting proteins: O14641 and O14640 |
Pubmed |
SVM Score :0.0 |
| We report the isolation and characterization of two new genomic loci corresponding to the mouse Dishevelled ( Dvl ) genes Dvl 2 and Dvl 3 . ^^^ Dvl 2 and Dvl 3 genomic clones were isolated from a mouse 129 strain gamma FIXII genomic library and have identical exon / intron organization to Dvl 1 . ^^^ |
|
| Interacting proteins: O14641 and O14640 |
Pubmed |
SVM Score :0.0 |
| A putative effector molecule for WNT 3 signaling , the cytoplasmic protein Dishevelled 2 ( DVL 2 ) , is normally present at high levels in a subset of cells in the outer root sheath and in precursor cells of the hair shaft cortex and cuticle which lie immediately adjacent to Wnt 3 expressing cells . ^^^ Overexpression of Dvl 2 in the outer root sheath mimics the short hair phenotype produced by overexpression of Wnt 3 , supporting the hypothesis that Wnt 3 and Dvl 2 have the potential to act in the same pathway in the regulation of hair growth . ^^^ |
|
| Interacting proteins: O14641 and O14640 |
Pubmed |
SVM Score :0.0 |
| To demonstrate functional conservation of Dsh family proteins , two mouse homologs of Drosophila Dsh , Dvl 1 and Dvl 2 , were biochemically characterized in mouse and Drosophila cell culture systems . ^^^ |
|
| Interacting proteins: O14641 and O14640 |
Pubmed |
SVM Score :0.0 |
| In vitro translated beta catenin , Dvl 2 , and Dvl 3 are phosphorylated by CK 2 . ^^^ |
|
| Interacting proteins: O14641 and O14640 |
Pubmed |
SVM Score :0.0 |
| Here we report the identification of Dishevelled 1 and Dishevelled 2 ( Dvl 1 and Dvl 2 ) as beta arrestin 1 ( betaarr 1 ) interacting proteins . ^^^ Interestingly , whereas betaarr 1 or Dvl alone leads to low level stimulation of LEF ( 2 to 5 fold ) , coexpression of betaarr 1 with either Dvl 1 or Dvl 2 leads to a synergistic activation of LEF ( up to 16 fold ) . ^^^ |
|
| Interacting proteins: O14641 and O14640 |
Pubmed |
SVM Score :0.0 |
| These skeletal abnormalities were more pronounced in mice deficient for both Dvl 1 and Dvl 2 . ^^^ Somite differentiation markers used to analyze Dvl 2 ( / ) and Dvl 1 ( / ) ; Dvl 2 ( / ) mutant embryos revealed mildly aberrant expression of Uncx4 . 1 , delta 1 and myogenin , suggesting defects in somite segmentation . ^^^ Thus , Dvl 2 is essential for normal cardiac morphogenesis , somite segmentation and neural tube closure , and there is functional redundancy between Dvl 1 and Dvl 2 in some phenotypes . . ^^^ |
|
| Interacting proteins: O14641 and O14640 |
Pubmed |
SVM Score :0.0 |
| Dishevelled 1 ( DVL 1 ) , DVL 2 and DVL 3 are DIX domain proteins implicated in the WNT signaling pathway . ^^^ |
|
| Interacting proteins: O14641 and O14640 |
Pubmed |
SVM Score :0.0 |
| Endocytosis of Frizzled 4 ( Fz 4 ) in human embryonic kidney 293 cells was dependent on added Wnt5A protein and was accomplished by the multifunctional adaptor protein beta arrestin 2 ( betaarr 2 ) , which was recruited to Fz 4 by binding to phosphorylated Dvl 2 . ^^^ |
|
| Interacting proteins: O14641 and O14640 |
Pubmed |
SVM Score :0.0 |
| In addition , we show that the two known Vangl 2 loss of function mutations identified in two independent Lp alleles associated with neural tube defects impair binding to Dvl 1 , Dvl 2 , and Dvl 3 . ^^^ |
|
| Interacting proteins: O14641 and O14640 |
Pubmed |
SVM Score :0.0 |
| Dpr 1 synergizes with zebrafish Dvl 2 , and with the Dvl interacting kinases CK1epsilon , Par 1 and CK 2 , in activating target genes . ^^^ |
|
| Interacting proteins: O14641 and O14640 |
Pubmed |
SVM Score :0.0 |
| Vangl 1 ( Strabismus 2 ) and Vangl 2 ( Strabismus 1 or Ltap ) are mammalian homologs of Drosophila Vang interacting with PRICKLE 1 , PRICKLE 2 , ANKRD 6 , DVL 1 , DVL 2 , DVL 3 , KAI 1 and MAGI 3 . ^^^ |
|
| Interacting proteins: O14641 and O14640 |
Pubmed |
SVM Score :0.0 |
| Human VANGL 1 , VANGL 2 ( Van Gogh homologs ) , CELSR 1 , CELSR 2 , CELSR 3 ( Starry night homologs ) , DVL 1 , DVL 2 , DVL 3 ( Dishevelled homologs ) , PRICKLE 1 , PRICKLE 2 ( Prickle homologs ) , and ANKRD 6 ( Diego homolog ) are core PCP signaling molecules . ^^^ |
|
| Interacting proteins: O14641 and O14640 |
Pubmed |
SVM Score :0.0 |
| Knockdown of Dpr 1 by RNA interference up regulates endogenous Dvl 2 protein . ^^^ |
|
| Interacting proteins: O14641 and O14640 |
Pubmed |
SVM Score :0.0 |
| Vangl 2 and Dvl 2 were preferentially expressed in ventricular zones , in keeping with their role during neural tube closure , where they could be partners of Celsr 1 . ^^^ |
|
| Interacting proteins: O14641 and O14640 |
Pubmed |
SVM Score :0.0 |
| Here we show , using mice with null mutations in two mammalian Dishevelled homologs , Dvl 1 and Dvl 2 , that during neurulation a homologous mammalian PCP pathway regulates concomitant lengthening and narrowing of the neural plate , a morphogenetic process defined as convergent extension . ^^^ Dvl 2 genetically interacts with Loop tail , a point mutation in the mammalian PCP gene Vangl 2 , during neurulation . ^^^ By generating Dvl 2 BAC ( bacterial artificial chromosome ) transgenes and introducing different domain deletions and a point mutation identical to the dsh 1 allele in fly , we further demonstrated a high degree of conservation between Dvl function in mammalian convergent extension and the PCP pathway in fly . ^^^ In the neuroepithelium of neurulating embryos , Dvl 2 shows DEP domain dependent membrane localization , a pre requisite for its involvement in convergent extension . ^^^ Intriguing , the Loop tail mutation that disrupts both convergent extension in the neuroepithelium and PCP in the cochlea does not disrupt Dvl 2 membrane distribution in the neuroepithelium , in contrast to its drastic effect on Dvl 2 localization in the cochlea . ^^^ |
|
| Interacting proteins: O14641 and O14640 |
Pubmed |
SVM Score :0.0 |
| WNT5A , WNT5B , WNT 11 , FZD 3 , FZD 6 , VANGL 1 , VANGL 2 , DVL 1 , DVL 2 , DVL 3 , PRICKLE 1 , PRICKLE 2 , ANKRD 6 , NKD 1 , NKD 2 , DAAM 1 , DAAM 2 , CELSR 1 , CELSR 2 , CELSR 3 , ROR 1 and ROR 2 are planar cell polarity ( PCP ) signaling molecules implicated in the regulation of cellular polarity , convergent extension , and invasion . ^^^ |
|
| Interacting proteins: O14641 and O14640 |
Pubmed |
SVM Score :0.0 |
| Specific knock down of Dvl 2 expression markedly reduced Wnt 3a dependent changes in cell shape and movement , suggesting that this Dvl isoform had a predominant role in mediating Wnt 3a dependent motility in Chinese hamster ovary cells . . ^^^ |
|
| Interacting proteins: O14641 and O14640 |
Pubmed |
SVM Score :0.0 |
| NA |
|