| Interacting proteins: P84022 and O14640 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVES : To determine the in vivo interaction between Smad 3 and Dishevelled 1 . ^^^ RESULTS : Smad 3 and Dishevelled isoforms 1 , 2 , and 3 all bind Smad 3 in glutathione S transferase ( GST ) pull down assays and Smad 3 binds to Dishevelled 1 in vivo . ^^^ Stimulation of the transforming growth factor beta ( TGFbeta ) pathway leads to increased binding of Smad 3 and Dishevelled 1 in vivo . ^^^ CONCLUSION : Smad 3 binds all three known isoforms of Dishevelled and binds Dishevelled 1 in vivo . ^^^ TGFbeta signaling modulates the interaction between Smad 3 and Dishevelled 1 . . ^^^ |
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| Interacting proteins: P84022 and O14640 |
Pubmed |
SVM Score :0.0 |
| In yeast two hybrid and GST pull down assays , Dishevelled 1 and Smad 3 have been shown to physically interact through the C terminal one half of Dishevelled 1 and the MH 2 domain of Smad 3 . ^^^ |
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