| Interacting proteins: P49674 and O14640 |
Pubmed |
SVM Score :0.61904291 |
| Here we show that both CKI delta and CKI epsilon interacted directly with Dvl 1 , and that CKI phosphorylated multiple components of the Wnt regulated beta catenin degradation complex in vitro , including Dvl 1 , adenomatous polyposis coli ( APC ) , axin , and beta catenin . 0.61904291^^^ |
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| Interacting proteins: P49674 and O14640 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that Dvl 1 , casein kinase 1 epsilon ( CKI epsilon ) , and Frat 1 activate the Wnt signaling pathway cooperatively . ^^^ The amino acid region 228 250 of Dvl 1 was necessary for its binding to Frat 1 , and the interaction of Dvl 1 with Frat 1 was enhanced by CKI epsilon . ^^^ Dvl 1 , but not Dvl 1 ( Delta 228 250 ) , acted synergistically with CKI epsilon to activate Tcf 4 . ^^^ Depletion of CKI epsilon by double stranded RNA interference in HeLa S 3 cells led to the inhibition of Wnt 3a induced phosphorylation of Dvl and the binding of Dvl 1 to Frat 1 . ^^^ These results indicate that CKI epsilon dependent phosphorylation of Dvl enhances the formation of a complex of Dvl 1 with Frat 1 and that this complex leads to the activation of the Wnt signaling pathway . . ^^^ |
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| Interacting proteins: P49674 and O14640 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49674 and O14640 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49674 and O14640 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49674 and O14640 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49674 and O14640 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49674 and O14640 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49674 and O14640 |
Pubmed |
SVM Score :0.0 |
| NA |
|