| Interacting proteins: O15169 and O14640 |
Pubmed |
SVM Score :0.54118808 |
| The N terminal region of Dvl 1 , including its DIX domain , bound to Axin directly . 0.54118808^^^ |
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| Interacting proteins: O15169 and O14640 |
Pubmed |
SVM Score :0.60116039 |
| We found that Dvl interacts with Axin and with Frat 1 , both of which interact with GSK . 0.60116039^^^ Axin and Frat 1 interact with dvl and GSK , bridging Dvl to GSK in Wnt mediated regulation of LEF 1 . 0.57781303^^^ The observation that the Dvl binding domain of either Frat 1 or Axin was able to inhibit Wnt 1 induced LEF 1 activation suggests that the interactions between Dvl and Axin and between Dvl and Frat may be important for this signaling pathway . 0.53462728^^^ |
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| Interacting proteins: O15169 and O14640 |
Pubmed |
SVM Score :0.66633802 |
| CKIepsilon and Axin associated with different sites of Dvl , and CKIepsilon and Dvl interacted with distinct regions on Axin . 0.66633802^^^ |
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| Interacting proteins: O15169 and O14640 |
Pubmed |
SVM Score :0.0 |
| Dvl 1 , which was genetically shown to function upstream of GSK 3beta , inhibited the phosphorylation of Axin by GSK 3beta in vitro . ^^^ Furthermore , Wnt 3a containing conditioned medium down regulated Axin and accumulated beta catenin in L cells and expression of Dvl 1 ( DeltaPDZ ) , in which the PDZ domain was deleted , suppressed this action of Wnt 3a . ^^^ These results suggest that the phosphorylation of Axin is important for the regulation of its stability and that Wnt down regulates Axin through Dvl . . ^^^ |
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| Interacting proteins: O15169 and O14640 |
Pubmed |
SVM Score :0.0 |
| Other components of the Wnt signalling pathway , including Dvl , glycogen synthase kinase 3beta , beta catenin , and adenomatous polyposis coli , interact with Axin , and the phosphorylation and stability of beta catenin are regulated in the Axin complex . ^^^ |
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| Interacting proteins: O15169 and O14640 |
Pubmed |
SVM Score :0.0 |
| PP2C exists in a complex with Dvl , beta catenin , and Axin , a negative regulator of Wnt signaling . ^^^ |
|
| Interacting proteins: O15169 and O14640 |
Pubmed |
SVM Score :0.0 |
| Other components of the Wnt signaling pathway , including Dvl , glycogen synthase kinase 3beta ( GSK 3beta ) , beta catenin , and adenomatous polyposis coli ( APC ) , interact with Axin , and the phosphorylation and stability of beta catenin are regulated in the Axin complex . ^^^ |
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| Interacting proteins: O15169 and O14640 |
Pubmed |
SVM Score :0.0 |
| Axin forms a complex with adenomatous polyposis coli gene product , glycogen synthase kinase 3beta ( GSK 3beta ) , beta catenin , Dvl , and protein phosphatase 2A and functions as a scaffold protein in the Wnt signaling pathway . ^^^ Axam inhibited the complex formation of Dvl with Axin and the activity of Dvl to suppress GSK 3beta dependent phosphorylation of Axin . ^^^ These results suggest that Axam regulates the Wnt signaling pathway negatively by inhibiting the binding of Dvl to Axin . . ^^^ |
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| Interacting proteins: O15169 and O14640 |
Pubmed |
SVM Score :0.0 |
| In attempting to clarify the roles of Dvl in the Wnt signaling pathway , we identified a novel protein which binds to the PDZ domain of Dvl and named it Idax ( for inhibition of the Dvl and Axin complex ) . ^^^ Idax and Axin competed with each other for the binding to Dvl . ^^^ Immunocytochemical analyses showed that Idax was localized to the same place as Dvl in cells and that expression of Axin inhibited the colocalization of Dvl and Idax . ^^^ |
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| Interacting proteins: O15169 and O14640 |
Pubmed |
SVM Score :0.0 |
| Axin , a negative regulator of the Wnt signaling pathway , forms a complex with glycogen synthase kinase 3beta ( GSK 3beta ) , beta catenin , adenomatous polyposis coli ( APC ) gene product , and Dvl , and it regulates GSK 3beta dependent phosphorylation in the complex and the stability of beta catenin . ^^^ The binding site of PR61beta on Axin was different from those of GSK 3beta , beta catenin , APC , and Dvl . ^^^ |
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| Interacting proteins: O15169 and O14640 |
Pubmed |
SVM Score :0.0 |
| When the cells were transfected with the SMT3IP2 / Axam2 C500A mutant , which had neither isopeptidase nor carboxyl terminal hydrolase activity , or with the 1 352 mutant , which lacked the catalytic domain of the enzyme , again the beta catenin disappeared , indicating that the enzyme activities were not necessary for the instability of beta catenin in this transfection assay system and that its competition with Dvl for binding to Axin may be important for the instability of beta catenin as suggested previously for Axam ( Kadoya , T . , Kishida , S . , Fukui , A . , Hinoi , T . , Michiue , T . , Asashima , M . , and Kikuchi , A . ( 2000 ) J . ^^^ |
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| Interacting proteins: O15169 and O14640 |
Pubmed |
SVM Score :0.0 |
| We also showed that while both Axin and the DIX domain of Dishevelled ( Dvl ) could inhibit Dkk 2C2 induced activation of LEF 1 , the DEP domain of Dvl , which inhibited Wnt induced activation of LEF 1 , failed to inhibit the activation of LEF 1 by Dkk 2C2 or by an activated form of LRP 5 , LRPC 2 . ^^^ |
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| Interacting proteins: O15169 and O14640 |
Pubmed |
SVM Score :0.0 |
| Here we show that both CKI delta and CKI epsilon interacted directly with Dvl 1 , and that CKI phosphorylated multiple components of the Wnt regulated beta catenin degradation complex in vitro , including Dvl 1 , adenomatous polyposis coli ( APC ) , axin , and beta catenin . ^^^ |
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| Interacting proteins: O15169 and O14640 |
Pubmed |
SVM Score :0.0 |
| Rfz 9 also relocalizes Axin from the cytoplasm to the plasma membrane in the presence of Dvl 1 , suggesting that one of the consequences of Dvl 1 relocalization by Rfz 9 is to bring Axin to the cell membrane . . ^^^ |
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| Interacting proteins: O15169 and O14640 |
Pubmed |
SVM Score :0.0 |
| DIX domains are essential for the signal transduction of two major Wnt downstream mediators , Dvl and Axin . ^^^ Ccd 1 formed homomeric and heteromeric complexes with Dvl and Axin and activated TCF dependent transcription in vitro . ^^^ |
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| Interacting proteins: O15169 and O14640 |
Pubmed |
SVM Score :0.0 |
| Here , we show that Axin associates with microtubules and unexpectedly stabilizes microtubules through DVL . ^^^ We propose a model in which Axin , through DVL , stabilizes microtubules by inhibiting a pool of GSK 3beta , resulting in local changes in the phosphorylation of cellular targets . ^^^ |
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| Interacting proteins: O15169 and O14640 |
Pubmed |
SVM Score :0.0 |
| Axin , Ccd 1 ( coiled coil DIX 1 ) , and dishevelled ( Dvl or Dsh ) are three known DIX domain proteins that play important roles in Wnt signaling . ^^^ In addition , Dvl and Axin can activate the mitogen activated protein kinase JNK via distinct mechanisms , through interaction with MEKK1 / 4 and Rac GTPase , respectively . ^^^ JNK activation by Axin is regulated by several factors in the Wnt pathway , whereas little is known about cross regulation of Dvl mediated JNK activation . ^^^ In the present study , we have investigated whether Ccd 1 could play a regulatory role in Axin and Dvl mediated JNK activation . ^^^ Here we show that Ccd 1 drastically inhibited JNK activation both by Axin and by Dvl . ^^^ |
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| Interacting proteins: O15169 and O14640 |
Pubmed |
SVM Score :0.0 |
| Wnt ligands bind their receptors Frizzled and low density lipoprotein receptor related protein 5 / 6 and function through Disheveled ( Dvl ) , Axin , adenomatous polyposis coli , glycogen synthase kinase 3beta , and casein kinase ( CK ) 1 to stabilize beta catenin and induce lymphocyte enhancer binding factor ( LEF ) / T cell factor ( TCF ) dependent transcriptional activities . ^^^ |
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| Interacting proteins: O15169 and O14640 |
Pubmed |
SVM Score :0.0 |
| The beta catenin oncoprotein depends upon the association of Dvl and Axin proteins through their DIX domains , and its accumulation directs the expression of specific developmental related genes at the nucleus . ^^^ |
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| Interacting proteins: O15169 and O14640 |
Pubmed |
SVM Score :0.0 |
| In the canonical pathway , two DIX domain containing proteins , Dishevelled ( Dvl ) and Axin , regulate the degradation of beta catenin that activates Wnt target genes through TCF / LEF family transcription factors . ^^^ Ccd 1 forms homomeric and heteromeric complexes with Dvl and Axin , and regulates the neural patterning in zebrafish embryos through Wnt pathway activation . ^^^ |
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| Interacting proteins: O15169 and O14640 |
Pubmed |
SVM Score :0.0 |
| The observed abnormalities included overexpression of Wnt 1 , Frizzled 1 and 2 receptors , Dishevelled 1 , downregulation of Secreted frizzled related protein 1 , GSK 3beta inactivation , microsatellite instability at the Axin locus as well as induction of beta catenin target genes , such as glutamine synthetase , glutamate transporter 1 , and Wisp 1 . ^^^ |
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| Interacting proteins: O15169 and O14640 |
Pubmed |
SVM Score :0.0 |
| In the `` canonical ' ' Wnt signaling pathway , Disheveled ( Dvl ) is required to functionally inhibit the activity of the GSK3beta / Axin complex and thereby stabilize beta catenin . ^^^ |
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| Interacting proteins: O15169 and O14640 |
Pubmed |
SVM Score :0.0 |
| Immunoblotting demonstrated that Dvl , Axin , GSK 3beta , and beta catenin proteins are expressed in rat red and white gastrocnemius muscles . ^^^ |
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| Interacting proteins: O15169 and O14640 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15169 and O14640 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15169 and O14640 |
Pubmed |
SVM Score :0.0 |
| NA |
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