| Interacting proteins: Q9Y566 and O14490 |
Pubmed |
SVM Score :0.0 |
| The PDZ domain of Shank 1 from Rattus norvegicus and its complex with the C terminal octapeptide of GKAP were crystallized at 294 K using polyethylene glycol 20 000 and 6000 as precipitants . ^^^ |
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| Interacting proteins: Q9Y566 and O14490 |
Pubmed |
SVM Score :0.0 |
| Here we describe the crystal structures of Shank 1 PDZ in its peptide free form and in complex with the C terminal hexapeptide ( EAQTRL ) of guanylate kinase associated protein ( GKAP1a ) determined at 1 . 8 and 2 . 25 A resolutions , respectively . ^^^ |
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| Interacting proteins: Q9Y566 and O14490 |
Pubmed |
SVM Score :0.0 |
| We investigated the molecular mechanisms of Shank 1 targeting and synapse assembly by looking at the function of guanylate kinase associated protein ( GKAP ) and PSD 95 interactions . ^^^ Shank 1 when it is not associated to GKAP , which binds to the Shank PSD 95 Discs Large zona occludens 1 domain , forms filamentous and fusiform structures in which the Src homology 3 domain specifically interacts with the ankyrin repeat domain , thus allowing its multimerization via a novel form of intermolecular interaction . ^^^ |
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| Interacting proteins: Q9Y566 and O14490 |
Pubmed |
SVM Score :0.0 |
| We have identified here a novel neuronal GKAP / SAPAP / DAP binding protein and named it synamon . ^^^ Synamon interacts with the COOH terminal region of GKAP / SAPAP / DAP via the middle region containing a PSD 95 / Dlg A / ZO 1 domain . ^^^ Because synamon is composed of various protein interacting modules , it may also interact with proteins other than GKAP / SAPAP / DAP to organize the architecture of the PSD . . ^^^ |
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| Interacting proteins: Q9Y566 and O14490 |
Pubmed |
SVM Score :0.0 |
| NA |
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