| Interacting proteins: O00628 and P50542 |
Pubmed |
SVM Score :0.0 |
| PEX 5 and PEX 7 are the genes for peroxisomal targeting signal ( PTS ) 1 and 2 receptors , respectively . ^^^ |
|
| Interacting proteins: O00628 and P50542 |
Pubmed |
SVM Score :0.0 |
| Endogenous TRIM 37 is not imported into peroxisomes in peroxin 1 ( PEX 1 ( / ) ) and peroxin 5 ( PEX 5 ( / ) ) mutant fibroblasts but is imported normally in peroxin 7 ( PEX 7 ( / ) ) deficient fibroblasts , giving further evidence for a peroxisomal localization of TRIM 37 . ^^^ |
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| Interacting proteins: O00628 and P50542 |
Pubmed |
SVM Score :0.0 |
| Like Pex14p , Pex13p not only interacts with the PTS 1 receptor Pex5p , but also with the PTS 2 receptor Pex7p ; however , this association may be direct or indirect . ^^^ NH 2 terminal regions of Pex13p are required for its interaction with the PTS 2 receptor while the COOH terminal SH 3 domain alone is sufficient to mediate its interaction with the PTS 1 receptor . ^^^ |
|
| Interacting proteins: O00628 and P50542 |
Pubmed |
SVM Score :0.0 |
| In addition , we show that the peroxisomal import process mediated by the N terminal segment of Cit2p was not affected by the disruption of either PEX 5 ( encoding PTS 1 receptor ) or PEX 7 ( encoding PTS 2 receptor ) . . ^^^ |
|
| Interacting proteins: O00628 and P50542 |
Pubmed |
SVM Score :0.0 |
| We have found that peroxisomal targeting of a fusion protein consisting of Eci1p in front of green fluorescent protein ( GFP ) is not dependent on Pex7p ( the PTS 2 receptor ) , ruling out a PTS 2 mechanism , but is dependent on Pex5p ( the PTS 1 receptor ) . ^^^ |
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| Interacting proteins: O00628 and P50542 |
Pubmed |
SVM Score :0.0 |
| In immunoisolation experiments Pex12p was co purified with the RING finger protein Pex10p , the PTS 1 receptor Pex5p and the docking proteins for the PTS 1 and the PTS 2 receptor at the peroxisomal membrane , Pex13p and Pex14p . ^^^ |
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| Interacting proteins: O00628 and P50542 |
Pubmed |
SVM Score :0.0 |
| Functional similarity between the peroxisomal PTS 2 receptor binding protein Pex18p and the N terminal half of the PTS 1 receptor Pex5p . ^^^ |
|
| Interacting proteins: O00628 and P50542 |
Pubmed |
SVM Score :0.0 |
| Deficiencies in peroxisomal targeting are also found in Saccharomyces cerevisiae pex 5 and pex 7 mutants , which show differential protein import deficiencies corresponding to two peroxisomal targeting sequences ( PTS 1 and PTS 2 ) . ^^^ |
|
| Interacting proteins: O00628 and P50542 |
Pubmed |
SVM Score :0.0 |
| On solid oleate medium , homozygous pex 5 , delta pex 6 , and pex 7 cells were unable to sporulate efficiently , whereas the wild type was . ^^^ |
|
| Interacting proteins: O00628 and P50542 |
Pubmed |
SVM Score :0.0 |
| Several of the mutants obtained possessed defective genes : the PEX 2 gene was defective in SK 24 and PT 54 ; the PEX 5 gene in SK 32 and the PEX 7 gene in PT 13 and PT 32 . ^^^ |
|
| Interacting proteins: O00628 and P50542 |
Pubmed |
SVM Score :0.0 |
| Morphological and biochemical analyses , making use of Chinese hamster ovary cell pex mutants such as the PTS 1 receptor impaired pex 5 and PTS 2 import defective pex 7 , as well as green fluorescent protein chimeras , revealed that both pre nsLTP and SCPx are imported into peroxisomes by the Pex5p mediated PTS 1 pathway . ^^^ |
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| Interacting proteins: O00628 and P50542 |
Pubmed |
SVM Score :0.0 |
| A mutation in PEX 5 that changes a conserved serine of this motif abrogates PTS 2 protein import in mammalian cells and reduces the interaction of PEX5L and PEX 7 in vitro . ^^^ |
|
| Interacting proteins: O00628 and P50542 |
Pubmed |
SVM Score :0.0 |
| Most proteins to be imported contain so called PTS 1 or PTS 2 targeting sequences recognized by , respectively , the receptor proteins PEX 5 and PEX 7 . ^^^ PEX 14 , a protein associated with the peroxisomal membrane , has been identified as a component of the docking complex and a point of convergence of the PEX 5 and PEX 7 dependent import pathways . ^^^ |
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| Interacting proteins: O00628 and P50542 |
Pubmed |
SVM Score :0.0 |
| The peroxisomal membrane protein PEX 14 is a key component of the peroxisomal import machinery and may be the initial docking site for the two import receptors PEX 5 and PEX 7 . ^^^ |
|
| Interacting proteins: O00628 and P50542 |
Pubmed |
SVM Score :0.0 |
| The Arabidopsis peroxisomal targeting signal type 2 receptor PEX 7 is necessary for peroxisome function and dependent on PEX 5 . ^^^ Most peroxisomal matrix proteins bear characterized Peroxisomal Targeting Signals ( PTS 1 or PTS 2 ) , which are bound by the receptors PEX 5 or PEX 7 , respectively , for import into peroxisomes . ^^^ We also demonstrate that the pex 5 1 PTS 1 receptor mutant , which contains a lesion in a domain conserved among PEX 7 binding proteins from various organisms , is defective not in PTS 1 protein import , but rather in PTS 2 protein import . ^^^ Combining these mutations in a pex 7 1 pex 5 1 double mutant abolishes detectable PTS 2 protein import and yields seedlings that are entirely sucrose dependent for establishment , suggesting a severe block in peroxisomal fatty acid beta oxidation . ^^^ Adult pex 7 1 pex 5 1 plants have reduced stature and bear abnormally shaped seeds , few of which are viable . ^^^ |
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| Interacting proteins: O00628 and P50542 |
Pubmed |
SVM Score :0.0 |
| Expression of the PEX 5 and PEX 7 genes was efficiently reduced by the double stranded RNA mediated interference in the transgenic Arabidopsis . ^^^ |
|
| Interacting proteins: O00628 and P50542 |
Pubmed |
SVM Score :0.0 |
| The core protein of this complex , Pex 14 , is thought to represent the initial docking site for the import receptors Pex 5 and Pex 7 . ^^^ |
|
| Interacting proteins: O00628 and P50542 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00628 and P50542 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00628 and P50542 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00628 and P50542 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00628 and P50542 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00628 and P50542 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00628 and P50542 |
Pubmed |
SVM Score :0.0 |
| NA |
|