| Interacting proteins: Q9NZU7 and O00555 |
Pubmed |
SVM Score :0.0 |
| CaV2 . 1 channels conduct P / Q type Ca2+ currents that are modulated by calmodulin ( CaM ) and the structurally related Ca2+ binding protein 1 ( CaBP 1 ) . ^^^ Coexpression of CaV2 . 1 and VILIP 2 in tsA 201 cells resulted in Ca2+ channel modulation distinct from CaM and CaBP 1 . ^^^ Differential regulation of CaV2 . 1 channels by CaM , VILIP 2 , CaBP 1 , and other neurospecific Ca2+ binding proteins is a potentially important determinant of Ca2+ entry in neurotransmission . . ^^^ |
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| Interacting proteins: Q9NZU7 and O00555 |
Pubmed |
SVM Score :0.0 |
| CaBP 1 positively shifts the voltage dependence of CaV2 . 1 activation , accelerates inactivation , and prevents paired pulse facilitation in a Ca2+ independent manner . ^^^ These results suggest a model in which nonmyristoylated CaBP 1 and VILIP 2 bind to CaV2 . 1 channels and regulate them like CaM , whereas myristoylation allows differential , Ca2+ independent regulation by the inactive EF hands of CaBP 1 and VILIP 2 , which differ in their positions in the protein structure . ^^^ Differential regulation of CaV2 . 1 channels by calcium binding protein 1 and visinin like protein 2 requires N terminal myristoylation . ^^^ |
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| Interacting proteins: Q9NZU7 and O00555 |
Pubmed |
SVM Score :0.0 |
| NA |
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