| Interacting proteins: O00482 and Q15466 |
Pubmed |
SVM Score :0.75923961 |
| This domain is a common target for coactivator interaction , and the SHP proteins can compete with p 160 coactivators for binding to LRH 1 . 0.75923961^^^ |
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| Interacting proteins: O00482 and Q15466 |
Pubmed |
SVM Score :0.57271563 |
| The functional interaction between the orphan nuclear receptors small heterodimer partner ( SHP ) and liver receptor homolog 1 ( LRH 1 ) , where SHP binds to LRH 1 and represses its constitutive transcriptional activity , is crucial for regulating genes involved in cholesterol homeostasis . 0.57271563^^^ |
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| Interacting proteins: O00482 and Q15466 |
Pubmed |
SVM Score :0.51507505 |
| Finally , interaction of SHP with FTF displaces FTF binding to its sites within the 12alpha hydroxylase promoter . 0.51507505^^^ |
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| Interacting proteins: O00482 and Q15466 |
Pubmed |
SVM Score :0.53692202 |
| It has been shown previously that hepatocyte nuclear factor 4alpha ( HNF 4 ) and the alpha ( 1 ) fetoprotein transcription factor ( FTF ) are activators of 7alpha and 12alpha hydroxylase transcription and that the small heterodimer partner ( SHP ) suppresses bile acid biosynthesis by heterodimerizing with FTF . 0.53692202^^^ |
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| Interacting proteins: O00482 and Q15466 |
Pubmed |
SVM Score :0.0 |
| Here , we show that repression is coordinately regulated by a triumvirate of nuclear receptors , including the bile acid receptor , FXR ; the promoter specific activator , LRH 1 ; and the promoter specific repressor , SHP . ^^^ Elevated SHP protein then inactivates LRH 1 by forming a heterodimeric complex that leads to promoter specific repression of both CYP7A1 and SHP . ^^^ |
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| Interacting proteins: O00482 and Q15466 |
Pubmed |
SVM Score :0.0 |
| A regulatory cascade of the nuclear receptors FXR , SHP 1 , and LRH 1 represses bile acid biosynthesis . ^^^ SHP 1 represses expression of CYP7A1 by inhibiting the activity of liver receptor homolog 1 ( LRH 1 ) , an orphan nuclear receptor that is known to regulate CYP7A1 expression positively . ^^^ |
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| Interacting proteins: O00482 and Q15466 |
Pubmed |
SVM Score :0.0 |
| Phenotype analyses of knock out or transgenic mice pointed out the respective role of the `` enterohepatic ' ' orphan nuclear receptors LXRalpha , LXRB , FXR , LRH 1 , the nuclear receptor PPARalpha , and their heterodimeric partner RXR , as well as the peculiar receptor SHP . ^^^ |
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| Interacting proteins: O00482 and Q15466 |
Pubmed |
SVM Score :0.0 |
| SHP expression is regulated by several other members of the nuclear receptor superfamily , including the orphan receptors SF 1 and LRH 1 , and the bile acid receptor FXR . ^^^ |
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| Interacting proteins: O00482 and Q15466 |
Pubmed |
SVM Score :0.0 |
| In a study of factors that inhibit LRH 1 , we have examined the ability of short heterodimer partner ( SHP ) to inhibit aromatase transcription mediated by LRH 1 in preadipocytes . ^^^ RT PCR analysis indicated that both LRH 1 and SHP are expressed in human preadipocytes . ^^^ Expression of SHP completely inhibited activity of an aromatase promoter 2 reporter gene induced by LRH 1 . ^^^ The combined treatment of forskolin and phorbol ester ( which mimic PGE 2 ) as well as LRH 1 , which maximally induced reporter gene expression ( 140 fold ) , was also completely inhibited by SHP . ^^^ This effect of SHP was mediated by inhibition of LRH 1 transcriptional activity , as measured by activity of GAL 4 LRH 1 fusion constructs , and by inhibition of LRH 1 binding to promoter 2 . ^^^ |
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| Interacting proteins: O00482 and Q15466 |
Pubmed |
SVM Score :0.0 |
| Finally , we show that the transcriptional repressor SHP ( small heterodimer partner ) suppressed APOAI gene expression by inhibiting LRH 1 transcriptional activity . ^^^ |
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| Interacting proteins: O00482 and Q15466 |
Pubmed |
SVM Score :0.0 |
| To define the molecular mechanisms underlying this regulation and the role that class 2 NRs and associated members [ liver receptor homolog 1 ( LRH 1 ) and short heterodimer partner ( SHP ) ] play , we have analyzed the ontogeny of NR expression during liver development . ^^^ However , mRNA levels peaked close to that of adult rats ( > 6 wk old rats ) by 4 wk of age for farnesoid 10 receptor ( FXR ) , pregnane 10 receptor ( PXR ) , liver 10 receptor alpha ( LXRalpha ) , peroxisome proliferator activated receptor alpha ( PPARalpha ) , retinoid acid receptor alpha ( RARalpha ) , LRH 1 , and SHP , whereas RXRalpha mRNA lagged behind . ^^^ |
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| Interacting proteins: O00482 and Q15466 |
Pubmed |
SVM Score :0.0 |
| Specifically , the molecular aspects and functional impact of the aryl hydrocarbon receptor ( AhR ) , nuclear factor E 2 p45 related factor 2 ( N ( r ) f 2 ) , hepatocyte nuclear factor 1alpha ( HNF1alpha ) , constitutive androstane receptor ( LAR ) , pregnane 10 receptor ( PXR ) , farnesoid 10 receptor ( FXR ) , peroxisome proliferator activated receptor alpha ( PPAR ( alpha ) ) , hepatocyte nuclear factor 4alpha ( HNF4alpha ) , vitamin D receptor ( VDR ) , liver receptor homolog 1 ( LRH 1 ) , liver 10 receptor ( LXR ( alpha ) ) , small heterodimer partner 1 ( SHP 1 ) , and glucocorticoid receptor ( GR ) on gene expression are detailed . ^^^ |
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| Interacting proteins: O00482 and Q15466 |
Pubmed |
SVM Score :0.0 |
| Modulation of human nuclear receptor LRH 1 activity by phospholipids and SHP . ^^^ |
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| Interacting proteins: O00482 and Q15466 |
Pubmed |
SVM Score :0.0 |
| Bile acids reduce SR BI expression in hepatocytes by a pathway involving FXR / RXR , SHP , and LRH 1 . ^^^ Bile acid activated FXR / RXR represses expression of CYP7A1 , the rate limiting enzyme during bile acid synthesis , by inducing the expression of SHP , which inhibits LXR / RXR and LRH 1 transactivation of CYP7A1 . ^^^ |
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| Interacting proteins: O00482 and Q15466 |
Pubmed |
SVM Score :0.0 |
| Ostalpha and Ostbeta promoter activities were increased by coexpression of LRH 1 and decreased by coexpression of SHP . ^^^ |
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| Interacting proteins: O00482 and Q15466 |
Pubmed |
SVM Score :0.0 |
| FXR activating ligands inhibit rabbit ASBT expression via FXR SHP FTF cascade . ^^^ Increasing the SHP protein notably inhibited FTF dependent trans activation of rabbit ASBT . ^^^ Only FXR activating ligands can downregulate rabbit ASBT expression through the regulatory cascade FXR SHP FTF . . ^^^ |
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| Interacting proteins: O00482 and Q15466 |
Pubmed |
SVM Score :0.0 |
| The mRNA levels of Cyp7a1 and the nuclear receptors FXR ( farnesoid 10 receptor ) , SHP ( small heterodimer partner ) and FTF ( alpha fetoprotein transcription factor ) were not modified , whereas those of Cyp8b1 were enhanced and those of Cyp 27 were reduced . ^^^ In conclusion , during rat hepatocarcinogenesis , the expression of transporters / enzymes responsible for BA homoeostasis is changed due to mechanisms other than those controlled by FXR / SHP / FTF . ^^^ |
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| Interacting proteins: O00482 and Q15466 |
Pubmed |
SVM Score :0.0 |
| The levels of mRNA of alpha fetoprotein transcription factor ( FTF ) and small heterodimer partner ( SHP ) were first reduced ( day 1 ) and then ( days 2 3 ) increased , when those of farnesoid 10 receptor ( FXR ) were also transiently enhanced . ^^^ |
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| Interacting proteins: O00482 and Q15466 |
Pubmed |
SVM Score :0.0 |
| However , liver expresses a close relative of SF 1 , the orphan fetoprotein transcription factor ( FTF ) , and FTF can also transactivate the SHP promoter . ^^^ These results suggest that alterations in the levels or activities of SF 1 or FTF could modulate SHP expression in appropriate tissues and thereby affect a variety of receptor dependent signaling pathways . . ^^^ |
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| Interacting proteins: O00482 and Q15466 |
Pubmed |
SVM Score :0.0 |
| Bile acids and FXR repressed endogenous CYP7A1 but stimulated alpha fetoprotein transcription factor ( FTF ) and small heterodimer partner ( SHP ) mRNA expression in HepG 2 cells . ^^^ Feeding of rats with chenodeoxycholic acid repressed CYP7A1 , induced FTF , but had no effect on SHP mRNA expression in the liver . ^^^ FTF strongly repressed CYP7A1 transcription in a dose dependent manner , and SHP further inhibited CYP7A1 in HepG 2 cells , but not in HEK 293 cells . ^^^ FXR only moderately stimulated SHP transcription , whereas FTF strongly inhibited SHP transcription in HepG 2 cells . ^^^ Results revealed that FTF was a dominant negative factor that was induced by bile acid activated FXR to inhibit both CYP7A1 and SHP transcription . ^^^ |
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| Interacting proteins: O00482 and Q15466 |
Pubmed |
SVM Score :0.0 |
| It has been recently reported that bile acid activated farnesoid 10 receptor ( FXR ) induces the small heterodimer partner ( SHP ) that interacts with alpha fetoprotein transcription factor ( FTF ) and down regulates CYP7A1 transcription . ^^^ This was associated with an increase in FTF mRNA expression , but SHP mRNA expression was not altered . ^^^ |
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| Interacting proteins: O00482 and Q15466 |
Pubmed |
SVM Score :0.0 |
| Diet experiments support a model where FTF is quenched both by activated c Jun , and by SHP as a stronger feedback mechanism to repress CYP7A1 . ^^^ |
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| Interacting proteins: O00482 and Q15466 |
Pubmed |
SVM Score :0.0 |
| To determine whether the molecular structure of the promoter is responsible for this downregulation , we cloned the rabbit CYP7A1 promoter , identified the binding sites for alpha fetoprotein transcription factor ( FTF ) and liver 10 receptor ( LXRalpha ) , and studied the effects of FTF , LXRalpha , and SHP on its transcription . ^^^ Increasing amounts of SHP abolished the effect of L / R , and FTF enhanced the ability of SHP to decrease promoter activity below baseline levels . ^^^ |
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| Interacting proteins: O00482 and Q15466 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00482 and Q15466 |
Pubmed |
SVM Score :0.0 |
| NA |
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