| Interacting proteins: O00482 and P51843 |
Pubmed |
SVM Score :0.0 |
| LXXLL related motifs in Dax 1 have target specificity for the orphan nuclear receptors Ad4BP / SF 1 and LRH 1 . ^^^ In vitro pull down experiments confirmed that Dax 1 interacts with Ad4BP / SF 1 and also with LRH 1 ( NR5A2 ) . ^^^ The target specificity of the LXXLL related motifs was indicated by the observations that Ad4BP / SF 1 , ERalpha ( NR3A1 ) , LRH 1 , ERR 2 ( NR3B2 ) , and fly FTZ F 1 ( NR5A3 ) interacted through their ligand binding domains with all the LXXLL related motifs in Dax 1 whereas HNF 4 ( NR2A1 ) and RORalpha ( NR1F1 ) did not . ^^^ |
|
| Interacting proteins: O00482 and P51843 |
Pubmed |
SVM Score :0.0 |
| The expression of Dax 1 was significantly impaired in knock out mice of the Ftz f 1 gene , which encodes Ad4BP / SF 1 . ^^^ |
|
| Interacting proteins: O00482 and P51843 |
Pubmed |
SVM Score :0.0 |
| Taken together , these observations suggest that the E box is indeed required for the expression of the FTZ F 1 gene , at least in mammalian species , but may not determine the tissue specific expression of the hFTZ F 1 gene , and that , unlike the steroidogenic CYP gene , the regulation of the hFTZ F 1 gene appears to be independent of both Ad4BP and DAX 1 . . ^^^ |
|
| Interacting proteins: O00482 and P51843 |
Pubmed |
SVM Score :0.0 |
| LXXLL motifs in Dax 1 have target specificity for the orphan nuclear receptors Ad4BP / SF 1 and LRH 1 . ^^^ |
|
| Interacting proteins: O00482 and P51843 |
Pubmed |
SVM Score :0.0 |
| DAX 1 inhibited LRH 1 stimulated HSD3B2 , which was maintained in the presence of dibutyryl cAMP . ^^^ |
|
| Interacting proteins: O00482 and P51843 |
Pubmed |
SVM Score :0.0 |
| Recent evidence suggests a broader functional role for DAX 1 as a negative coregulator of estrogen receptor ( ER , NR3A1 2 ) , liver receptor homologue 1 ( LRH 1 , NR5A2 ) , androgen receptor ( AR , NR3C4 ) , and progesterone receptor ( PR , NR3C3 ) , each by distinct repression mechanisms . ^^^ |
|
| Interacting proteins: O00482 and P51843 |
Pubmed |
SVM Score :0.0 |
| For the first time , the present study suggests that FSH activated p 38 MAPK signal pathway regulates progesterone and estrogen production in GCs differentially , and that the transcription factors LRH 1 and DAX 1 might play important roles in the process . . ^^^ |
|
| Interacting proteins: O00482 and P51843 |
Pubmed |
SVM Score :0.0 |
| Mapping in pig of genes involved in sexual differentiation : AMH , WT 1 , FTZF 1 , SOX 2 , SOX 9 , AHC , and placental and embryonic CYP 19 . ^^^ |
|
| Interacting proteins: O00482 and P51843 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00482 and P51843 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00482 and P51843 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00482 and P51843 |
Pubmed |
SVM Score :0.0 |
| NA |
|