| Synergy between LRH 1 and beta catenin induces G 1 cyclin mediated cell proliferation . ^^^ We show here that LRH 1 induces cell proliferation through the concomitant induction of cyclin D 1 and E 1 , an effect that is potentiated by its interaction with beta catenin . ^^^ Whereas beta catenin coactivates LRH 1 on the cyclin E 1 promoter , LRH 1 acts as a potent tissue restricted coactivator of beta catenin on the cyclin D 1 promoter . ^^^ The implication of LRH 1 in cell proliferation highlights an unanticipated crosstalk between LRH 1 and the beta catenin / Tcf4 signaling pathway , which is relevant for the renewal of intestinal crypt cells . . ^^^ |