| Interacting proteins: O00329 and P16333 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00329 and P16333 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00329 and P16333 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00329 and P16333 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00329 and P16333 |
Pubmed |
SVM Score :0.0 |
| The peptidimer specifically recognizes Grb 2 and does not interact with PI3K or Nck , two SH 3 domain containing adaptors . ^^^ |
|
| Interacting proteins: O00329 and P16333 |
Pubmed |
SVM Score :0.0 |
| On the other hand , full length Lck overexpressed in Sf 9 cells , which is tyrosine phosphorylated at least on two sites , can interact in vitro with the SH 2 from Lck , phospholipase C ( PLC ) gamma 1 , p 85 ( the regulatory subunit of phosphatidyl inositol 3 kinase ( PI3K ) ) and Nck and with the full length Grb 2 . ^^^ |
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| Interacting proteins: O00329 and P16333 |
Pubmed |
SVM Score :0.0 |
| In both M 23 and MM 55 cells , HGF induces association with MET / HGFR and increased tyrosine phosphorylation of the SH 2 domain containing proteins PI3K , GAP and NCK . ^^^ We therefore suggest that the second messenger proteins PI3K , GAP and NCK , and possibly the protein products of the c fos , c jun , junB , junD and c myc genes , are important elements in the HGF induced mitogenic pathway in the normal mouse epithelial cell lines M 23 and MM55 . . ^^^ |
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| Interacting proteins: O00329 and P16333 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylation of IRS 1 causes it to associate with the src homology 2 ( SH 2 ) domains of at least four other proteins : phosphatidylinositol 3 ' kinase ( PI3K ) , growth factor receptor bound protein 2 ( GRB 2 ) , Nck , and Syp . ^^^ |
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| Interacting proteins: O00329 and P16333 |
Pubmed |
SVM Score :0.0 |
| We examined the interactions of certain proteins with a SH 2 domain with Flt 1 and KDR using the yeast two hybrid system and found that Nck , SHP 2 , PLC gamma , and PI3K p 85 bind to Flt 1 . ^^^ Nck , SHP 2 , and PI3K bind to Y 1213 of Flt 1 . ^^^ These results suggest that Nck , SHP 2 , PLC gamma , and PI3K play important roles in Flt 1 signal transduction and that Y 1213 of Flt 1 is a major binding site of PI3K , Nck , and SHP 2 . . ^^^ |
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| Interacting proteins: O00329 and P16333 |
Pubmed |
SVM Score :0.0 |
| Expression of a partially activated A Raf mutant resulted in decreased tyrosine phosphorylation of the PDGFR , specifically on Y 857 ( autophosphorylation site ) and Y 1021 ( phospholipase Cgamma 1 ( PLCgamma 1 ) binding site ) , but not the binding sites for other signalling proteins ( Nck , phosphatidylinositol 3 ' kinase ( PI3K ) , RasGAP , Grb 2 , SHP ) . ^^^ |
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