| Interacting proteins: O00291 and P05549 |
Pubmed |
SVM Score :1.2782217 |
| Here , we show that huntingtin interacting protein 1 ( HIP 1 ) , a binding partner of huntingtin , copurifies with brain clathrin coated vesicles and associates directly with both AP 2 and clathrin . 1.2782217^^^ |
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| Interacting proteins: O00291 and P05549 |
Pubmed |
SVM Score :0.64398464 |
| HIP 1 binds to the clathrin adaptor protein 2 ( AP 2 ) and the terminal domain of the clathrin heavy chain , predominantly through a small fragment encompassing amino acids 276 335 . 0.64398464^^^ |
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| Interacting proteins: O00291 and P05549 |
Pubmed |
SVM Score :0.0 |
| However , in cells expressing mutant CXCR 2 defective in AP 2 and HIP binding , i . e . with a mutation in the LLKIL motif , PH Akt GFP does not localize to the leading edge in response to ligand . ^^^ |
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| Interacting proteins: O00291 and P05549 |
Pubmed |
SVM Score :0.0 |
| Huntingtin Interacting Protein 1 ( HIP 1 ) binds clathrin and AP 2 , is overexpressed in multiple human tumors , and transforms fibroblasts . ^^^ |
|
| Interacting proteins: O00291 and P05549 |
Pubmed |
SVM Score :0.0 |
| Sequence analysis of the 5 ' flanking region revealed numerous potential binding sites for transcription factors Sp 1 and AP 2 and one putative HIP 1 binding site . ^^^ |
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| Interacting proteins: O00291 and P05549 |
Pubmed |
SVM Score :0.0 |
| The putative promoter region of the gene contained no obvious TATA or CCAAT element in the expected positions , but multiple putative binding sites for transcriptional factors , such as Sp 1 , AP 1 , AP 2 , AP 3 , EGR 1 , EGR 2 , NF kappaB and HIP 1 , were detected . ^^^ |
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| Interacting proteins: O00291 and P05549 |
Pubmed |
SVM Score :0.0 |
| We also show that HIP 1 physically associates with clathrin and AP 2 , the major components of the clathrin coat . ^^^ |
|
| Interacting proteins: O00291 and P05549 |
Pubmed |
SVM Score :0.0 |
| HIP 1 and HIP 12 display differential binding to F actin , AP 2 , and clathrin . ^^^ We now report that HIP 1 and HIP 12 are major components of the clathrin coat that interact but differ in their ability to bind clathrin and the clathrin adaptor AP 2 . ^^^ HIP 1 contains a clathrin box and AP 2 consensus binding sites that display high affinity binding to the terminal domain of the clathrin heavy chain and the ear domain of the AP 2 alpha subunit , respectively . ^^^ |
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| Interacting proteins: O00291 and P05549 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00291 and P05549 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00291 and P05549 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00291 and P05549 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00291 and P05549 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00291 and P05549 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00291 and P05549 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00291 and P05549 |
Pubmed |
SVM Score :0.0 |
| NA |
|