| Interacting proteins: Q03164 and O00255 |
Pubmed |
SVM Score :0.0 |
| Menin , a product of the MEN 1 tumor suppressor gene , is also a component of the 1 MDa MLL complex . ^^^ Leukemia proto oncoprotein MLL forms a SET 1 like histone methyltransferase complex with menin to regulate Hox gene expression . ^^^ Menin , a product of the MEN 1 tumor suppressor gene , is also a component of the 1 MDa MLL complex . ^^^ Abrogation of menin expression phenocopies loss of MLL and reveals a critical role for menin in the maintenance of Hox gene expression . ^^^ Oncogenic mutant forms of MLL retain an ability to interact with menin but not other identified complex components . ^^^ |
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| Interacting proteins: Q03164 and O00255 |
Pubmed |
SVM Score :0.0 |
| We have recently shown that menin , the MEN 1 protein product , interacts with mixed lineage leukemia ( MLL ) family proteins in a histone methyltransferase complex including Ash 2 , Rbbp 5 , and WDR 5 . ^^^ Menin and MLL cooperatively regulate expression of cyclin dependent kinase inhibitors . ^^^ Menin activates transcription by means of a mechanism involving recruitment of MLL to the p27Kip1 and p18Ink4c promoters and coding regions . ^^^ Loss of function of either MLL or menin results in down regulation of p27Kip1 and p18Ink4c expression and deregulated cell growth . ^^^ These findings suggest that regulation of cyclin dependent kinase inhibitor transcription by cooperative interaction between menin and MLL plays a central role in menin ' s activity as a tumor suppressor . . ^^^ |
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| Interacting proteins: Q03164 and O00255 |
Pubmed |
SVM Score :0.0 |
| MLL 2 also has histone H 3 Lys 4 methyltransferase activity that is dependent on menin , a protein mutated in multiple neoplasia type 1 ( MEN 1 ) and which is required for normal Hox expression . ^^^ |
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| Interacting proteins: Q03164 and O00255 |
Pubmed |
SVM Score :0.0 |
| MLL normally associates with a cohort of highly conserved cofactors to form a macromolecular complex that includes menin , a product of the MEN 1 tumor suppressor gene , which is mutated in heritable and sporadic endocrine tumors . ^^^ The menin tumor suppressor protein is an essential oncogenic cofactor for MLL associated leukemogenesis . ^^^ We demonstrate here that oncogenic MLL fusion proteins retain an ability to stably associate with menin through a high affinity , amino terminal , conserved binding motif and that this interaction is required for the initiation of MLL mediated leukemogenesis . ^^^ Furthermore , menin is essential for maintenance of MLL associated but not other oncogene induced myeloid transformation . ^^^ Acute genetic ablation of menin reverses aberrant Hox gene expression mediated by MLL menin promoter associated complexes , and specifically abrogates the differentiation arrest and oncogenic properties of MLL transformed leukemic blasts . ^^^ |
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| Interacting proteins: Q03164 and O00255 |
Pubmed |
SVM Score :0.0 |
| To elucidate menin ' s role as a tumor suppressor and gain insights into the endocrine specific tumor phenotype in MEN 1 , we mapped the genomic binding sites of menin , MLL 1 , and Rbbp 5 , to approximately 20 , 000 promoters in HeLa S 3 , HepG 2 , and pancreatic islet cells using the strategy of chromatin immunoprecipitation coupled with microarray analysis . ^^^ Menin was recently shown to interact with several components of a trithorax family histone methyltransferase complex including ASH 2 , Rbbp 5 , WDR 5 , and the leukemia proto oncoprotein MLL . ^^^ We found that menin , MLL 1 , and Rbbp 5 localize to the promoters of thousands of human genes but do not always bind together . ^^^ |
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| Interacting proteins: Q03164 and O00255 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q03164 and O00255 |
Pubmed |
SVM Score :0.0 |
| NA |
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