| Interacting proteins: O00255 and P84022 |
Pubmed |
SVM Score :0.66242119 |
| Menin interacts with Smad 3 , and antisense menin suppresses transforming growth factor type beta induced and Smad 3 induced transcriptional activity by inhibiting Smad3 / 4 DNA binding at specific transcriptional regulatory sites . 0.66242119^^^ |
|
| Interacting proteins: O00255 and P84022 |
Pubmed |
SVM Score :0.60361434 |
| These interactions are lost as the committed osteoblasts differentiate further at which time menin interacts with Smad 3 , mediating the negative regulation of Runx 2 by TGF beta . 0.60361434^^^ |
|
| Interacting proteins: O00255 and P84022 |
Pubmed |
SVM Score :0.0 |
| The MEN 1 gene encodes menin , a nuclear protein interacting with JunD / AP1 , Smad 3 , NFkappaB , and other proteins involved in transcription and cell growth regulation . ^^^ Taken together , most missense and in frame MEN 1 genomic alterations affect one or all domains of menin interacting with JunD [ codons 1 40 ; 139 242 ; 323 428 ] , Smad 3 [ distal to codon 478 ] , and NFkappaB [ codons 276 479 ] , three major effectors in transcription and cell growth regulation . ^^^ |
|
| Interacting proteins: O00255 and P84022 |
Pubmed |
SVM Score :0.0 |
| Mutational analysis of Smad 3 , a candidate tumor suppressor implicated in TGF beta and menin pathways , in parathyroid adenomas and enteropancreatic endocrine tumors . ^^^ Interest has focused on Smad 3 as a candidate endocrine tumor suppressor gene because 1 ) it is localized to 15q and 2 ) it encodes a TGF beta signaling molecule that has been identified as a binding partner of the multiple endocrine neoplasm type 1 gene product menin , itself involved in enteropancreatic and parathyroid neoplasia . ^^^ |
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| Interacting proteins: O00255 and P84022 |
Pubmed |
SVM Score :0.0 |
| Proteins of known function are shown to interact with Menin : JunD , nuclear factor KappaB , Smad 3 , Pem , Nm23H1 , glial fibrillary acidic protein , Vimentin , and probably P 53 . ^^^ |
|
| Interacting proteins: O00255 and P84022 |
Pubmed |
SVM Score :0.0 |
| Menin and Smad 3 were co immunoprecipitated , and combined menin and Smad 3 overexpression antagonized , whereas menin and the dominant negative Smad3DeltaC together enhanced BMP 2 induced transcriptional activity of Smad1 / 5 and Runx 2 . ^^^ |
|
| Interacting proteins: O00255 and P84022 |
Pubmed |
SVM Score :0.0 |
| In vitro studies have shown menin binding to JunD , Pem , Smad 3 , NF kappaB , nm23H1 , and RPA 2 proteins . ^^^ |
|
| Interacting proteins: O00255 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
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