| Interacting proteins: O00255 and P19838 |
Pubmed |
SVM Score :0.0 |
| The tumor suppressor protein menin interacts with NF kappaB proteins and inhibits NF kappaB mediated transactivation . ^^^ The NF kappaB proteins p 50 , p 52 and p 65 were found to interact specifically and directly with menin in vitro and in vivo . ^^^ The region of NF kappaB proteins sufficient for binding to menin is the N terminus . ^^^ Menin represses p 65 mediated transcriptional activation on NF kappaB sites in a dose dependent and specific manner . ^^^ Also , PMA ( phorbol 12 myristate 13 acetate ) stimulated NF kappaB activation is suppressed by menin . ^^^ |
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| Interacting proteins: O00255 and P19838 |
Pubmed |
SVM Score :0.0 |
| Menin binds and alters JunD , NF kappaB , Smad 3 mediated transcriptional activation . ^^^ |
|
| Interacting proteins: O00255 and P19838 |
Pubmed |
SVM Score :0.0 |
| In vitro studies have shown menin binding to JunD , Pem , Smad 3 , NF kappaB , nm23H1 , and RPA 2 proteins . ^^^ |
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| Interacting proteins: O00255 and P19838 |
Pubmed |
SVM Score :0.0 |
| In conclusion , the study demonstrated that in parathyroid tumors : ( 1 ) p 65 phosphorylation was dramatically increased by RET constitutive activation and was negatively correlated with menin expression , ( 2 ) p 65 phosphorylation was increased and reduced by TNFalpha and CaR agonists respectively , and ( 3 ) blockade of the NF kappaB pathway caused a significant decrease in cyclin D 1 expression . . ^^^ |
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| Interacting proteins: O00255 and P19838 |
Pubmed |
SVM Score :0.0 |
| The structure and nucleotide sequence of the NF kappa B 3 coding region in MEN 1 patients were compared with those of non MEN 1 subjects , to determine the potential role of this gene in MEN 1 tumorigenesis . ^^^ Southern blot analysis with constitutional DNA from probands of 14 independent MEN 1 families and DNA from four MEN 1 tumor specimens did not reveal any structural abnormality of the NF kappa B 3 gene . ^^^ Direct sequencing of cDNAs from two affected subjects from 2 different MEN 1 families , as well as nucleotide sequence analysis of exon / intron boundaries in these patients , did not reveal MEN 1 specific point mutations or other small structural aberrations in the NF kappa B 3 gene . ^^^ These results make it very unlikely that the NF kappa B 3 gene is the gene responsible for the development of MEN 1 . . ^^^ |
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| Interacting proteins: O00255 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00255 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00255 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00255 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00255 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00255 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00255 and P19838 |
Pubmed |
SVM Score :0.0 |
| NA |
|