| Interacting proteins: O00244 and P35670 |
Pubmed |
SVM Score :0.0 |
| The canine copper toxicosis locus is not syntenic with ATP7B or ATX 1 and maps to a region showing homology to human 2p21 . ^^^ |
|
| Interacting proteins: O00244 and P35670 |
Pubmed |
SVM Score :0.0 |
| We examined the roles of yeast Ccc 2 , a P type ATPase related to human ATP7A ( Menkes disease protein ) and ATP7B ( Wilson disease protein ) , as well as yeast Atx 1 , a cytosolic copper chaperone . ^^^ |
|
| Interacting proteins: O00244 and P35670 |
Pubmed |
SVM Score :0.0 |
| An important step in copper homeostasis is delivery of copper to a specific P type ATPase in the Golgi apparatus ( Ccc 2 in yeast , ATP7A and ATP7B in humans ) by a small copper chaperone protein ( Atx 1 in yeast , ATOX 1 in humans ) . ^^^ We demonstrate that ATOX 1 and Atx 1 preferentially interact with domains 2 and 4 of ATP7B and that Atx 1 interacts with both Ccc 2 domains . ^^^ |
|
| Interacting proteins: O00244 and P35670 |
Pubmed |
SVM Score :0.0 |
| Recently , the gene underlying Wilson disease ( ATP7B ) as well as copper transport genes hCTR 1 , hCTR 2 and ATOX 1 have been excluded as candidates for NICC in man and copper toxicosis in Bedlington terriers . ^^^ |
|
| Interacting proteins: O00244 and P35670 |
Pubmed |
SVM Score :0.0 |
| Atox 1 , a copper chaperone delivering copper to Atp7b , therefore became a potential candidate . ^^^ |
|
| Interacting proteins: O00244 and P35670 |
Pubmed |
SVM Score :0.0 |
| Homologs of the copper transporting ATPase ATP7B , defective in Wilson disease , and the copper chaperone ATOX 1 were potential candidates , but both have been excluded . ^^^ |
|
| Interacting proteins: O00244 and P35670 |
Pubmed |
SVM Score :0.0 |
| ATOX 1 is a cytoplasmic copper chaperone that interacts with the copper binding domain of the membrane copper transporters ATP7A and ATP7B . ^^^ |
|
| Interacting proteins: O00244 and P35670 |
Pubmed |
SVM Score :0.0 |
| Functional properties of the human copper transporting ATPase ATP7B ( the Wilson ' s disease protein ) and regulation by metallochaperone Atox 1 . ^^^ |
|
| Interacting proteins: O00244 and P35670 |
Pubmed |
SVM Score :0.0 |
| We have used isothermal titration calorimetry to measure the association constant ( K ( a ) ) and stoichiometry ( n ) values of Cu ( 1 ) binding to the WND metal binding domains and to their metallochaperone Atox 1 . ^^^ The association constants for both the chaperone and target domains are approximately 10 ( 5 ) to 10 ( 6 ) m ( 1 ) , suggesting that the handling of copper by Atox 1 and copper transfer between Atox 1 and WND are under kinetic rather than thermodynamic control . ^^^ |
|
| Interacting proteins: O00244 and P35670 |
Pubmed |
SVM Score :0.0 |
| Atox 1 delivers copper to the secretory pathway and docks with either copper transporting ATPase ATP7B in the liver or ATP7A in other cells . ^^^ |
|
| Interacting proteins: O00244 and P35670 |
Pubmed |
SVM Score :0.0 |
| Atox 1 interacts with Menkes disease protein and Wilson disease protein ( WD ) and functions in copper efflux . ^^^ |
|
| Interacting proteins: O00244 and P35670 |
Pubmed |
SVM Score :0.0 |
| In all tissues examined , mRNA expression for CTR 1 , ATOX 1 , ATP7A , and ATP7B was unchanged by iron deficiency . ^^^ |
|
| Interacting proteins: O00244 and P35670 |
Pubmed |
SVM Score :0.0 |
| Two proteins are known to interact with the ATP7B N terminal region : the copper chaperone ATOX 1 that delivers copper to ATP7B , and COMMD 1 ( MURR 1 ) that is potentially involved in vesicular copper sequestration . ^^^ |
|
| Interacting proteins: O00244 and P35670 |
Pubmed |
SVM Score :0.0 |
| Studies of the underlying defects in ATP7B and its suspected modifiers ATOX 1 and COMMD 1 are expected to unravel the disease ' s genotype phenotype correlation , and should lead to the design of improved drugs for ameliorating the suffering of patients . . ^^^ |
|
| Interacting proteins: O00244 and P35670 |
Pubmed |
SVM Score :0.0 |
| We use yeast and mammalian two hybrid systems , along with an in vitro assay to demonstrate a specific , copper dependent interaction between the six metal binding domains of the WD and MNK ATPases and the cytoplasmic copper chaperone HAH 1 . ^^^ |
|
| Interacting proteins: O00244 and P35670 |
Pubmed |
SVM Score :0.0 |
| On Western blot analysis all three resistant lines exhibited increased expression of one or the other of the two copper export pumps ( ATP7A or ATP7B ) with no change in the HAH 1 chaperone . ^^^ |
|
| Interacting proteins: O00244 and P35670 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00244 and P35670 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00244 and P35670 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00244 and P35670 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00244 and P35670 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00244 and P35670 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00244 and P35670 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O00244 and P35670 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35670 and O00244 |
Pubmed |
SVM Score :0.0 |
| The canine copper toxicosis locus is not syntenic with ATP7B or ATX 1 and maps to a region showing homology to human 2p21 . ^^^ |
|
| Interacting proteins: P35670 and O00244 |
Pubmed |
SVM Score :0.0 |
| Recently , the gene underlying Wilson disease ( ATP7B ) as well as copper transport genes hCTR 1 , hCTR 2 and ATOX 1 have been excluded as candidates for NICC in man and copper toxicosis in Bedlington terriers . ^^^ |
|
| Interacting proteins: P35670 and O00244 |
Pubmed |
SVM Score :0.0 |
| Atox 1 , a copper chaperone delivering copper to Atp7b , therefore became a potential candidate . ^^^ |
|
| Interacting proteins: P35670 and O00244 |
Pubmed |
SVM Score :0.0 |
| Homologs of the copper transporting ATPase ATP7B , defective in Wilson disease , and the copper chaperone ATOX 1 were potential candidates , but both have been excluded . ^^^ |
|
| Interacting proteins: P35670 and O00244 |
Pubmed |
SVM Score :0.0 |
| ATOX 1 is a cytoplasmic copper chaperone that interacts with the copper binding domain of the membrane copper transporters ATP7A and ATP7B . ^^^ |
|
| Interacting proteins: P35670 and O00244 |
Pubmed |
SVM Score :0.0 |
| On Western blot analysis all three resistant lines exhibited increased expression of one or the other of the two copper export pumps ( ATP7A or ATP7B ) with no change in the HAH 1 chaperone . ^^^ |
|
| Interacting proteins: P35670 and O00244 |
Pubmed |
SVM Score :0.0 |
| We examined the roles of yeast Ccc 2 , a P type ATPase related to human ATP7A ( Menkes disease protein ) and ATP7B ( Wilson disease protein ) , as well as yeast Atx 1 , a cytosolic copper chaperone . ^^^ |
|
| Interacting proteins: P35670 and O00244 |
Pubmed |
SVM Score :0.0 |
| Functional properties of the human copper transporting ATPase ATP7B ( the Wilson ' s disease protein ) and regulation by metallochaperone Atox 1 . ^^^ |
|
| Interacting proteins: P35670 and O00244 |
Pubmed |
SVM Score :0.0 |
| Atox 1 delivers copper to the secretory pathway and docks with either copper transporting ATPase ATP7B in the liver or ATP7A in other cells . ^^^ |
|
| Interacting proteins: P35670 and O00244 |
Pubmed |
SVM Score :0.0 |
| In all tissues examined , mRNA expression for CTR 1 , ATOX 1 , ATP7A , and ATP7B was unchanged by iron deficiency . ^^^ |
|
| Interacting proteins: P35670 and O00244 |
Pubmed |
SVM Score :0.0 |
| An important step in copper homeostasis is delivery of copper to a specific P type ATPase in the Golgi apparatus ( Ccc 2 in yeast , ATP7A and ATP7B in humans ) by a small copper chaperone protein ( Atx 1 in yeast , ATOX 1 in humans ) . ^^^ We demonstrate that ATOX 1 and Atx 1 preferentially interact with domains 2 and 4 of ATP7B and that Atx 1 interacts with both Ccc 2 domains . ^^^ |
|
| Interacting proteins: P35670 and O00244 |
Pubmed |
SVM Score :0.0 |
| Two proteins are known to interact with the ATP7B N terminal region : the copper chaperone ATOX 1 that delivers copper to ATP7B , and COMMD 1 ( MURR 1 ) that is potentially involved in vesicular copper sequestration . ^^^ |
|
| Interacting proteins: P35670 and O00244 |
Pubmed |
SVM Score :0.0 |
| Studies of the underlying defects in ATP7B and its suspected modifiers ATOX 1 and COMMD 1 are expected to unravel the disease ' s genotype phenotype correlation , and should lead to the design of improved drugs for ameliorating the suffering of patients . . ^^^ |
|
| Interacting proteins: P35670 and O00244 |
Pubmed |
SVM Score :0.0 |
| We use yeast and mammalian two hybrid systems , along with an in vitro assay to demonstrate a specific , copper dependent interaction between the six metal binding domains of the WD and MNK ATPases and the cytoplasmic copper chaperone HAH 1 . ^^^ |
|
| Interacting proteins: P35670 and O00244 |
Pubmed |
SVM Score :0.0 |
| Atox 1 interacts with Menkes disease protein and Wilson disease protein ( WD ) and functions in copper efflux . ^^^ |
|
| Interacting proteins: P35670 and O00244 |
Pubmed |
SVM Score :0.0 |
| We have used isothermal titration calorimetry to measure the association constant ( K ( a ) ) and stoichiometry ( n ) values of Cu ( 1 ) binding to the WND metal binding domains and to their metallochaperone Atox 1 . ^^^ The association constants for both the chaperone and target domains are approximately 10 ( 5 ) to 10 ( 6 ) m ( 1 ) , suggesting that the handling of copper by Atox 1 and copper transfer between Atox 1 and WND are under kinetic rather than thermodynamic control . ^^^ |
|
| Interacting proteins: P35670 and O00244 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35670 and O00244 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35670 and O00244 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35670 and O00244 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35670 and O00244 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35670 and O00244 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35670 and O00244 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35670 and O00244 |
Pubmed |
SVM Score :0.0 |
| NA |
|