| Interacting proteins: Q15836 and O00161 |
Pubmed |
SVM Score :0.0 |
| In order to better understand the molecular mechanisms of platelet granule secretion , we evaluated the effect of activation induced degranulation on three functional platelet SNARE proteins , SNAP 23 , VAMP 3 , and syntaxin 4 . ^^^ |
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| Interacting proteins: Q15836 and O00161 |
Pubmed |
SVM Score :0.0 |
| In a yeast two hybrid assay , syntaxins 2 , 3 and 4 interacted with SNAP 23 and VAMP 3 . ^^^ SNAP 23 interacted with syntaxin 3 , syntaxin 4 , VAMP 2 , VAMP 3 and VAMP 8 . ^^^ |
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| Interacting proteins: Q15836 and O00161 |
Pubmed |
SVM Score :0.0 |
| Botulinum neurotoxin B inhibits insulin stimulated glucose uptake into 3T3 L 1 adipocytes and cleaves cellubrevin unlike type A toxin which failed to proteolyze the SNAP 23 present . ^^^ |
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| Interacting proteins: Q15836 and O00161 |
Pubmed |
SVM Score :0.0 |
| Syntaxin 3 and SNAP 23 were codistributed at the apical plasma membrane where they formed NEM dependent SNARE complexes with TI VAMP and cellubrevin . ^^^ |
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| Interacting proteins: Q15836 and O00161 |
Pubmed |
SVM Score :0.0 |
| Increasing the amount of Munc 18 2 bound to syntaxin 3 by overexpression results in a marked decrease in the SNARE proteins SNAP 23 and cellubrevin bound to the syntaxin . ^^^ |
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| Interacting proteins: Q15836 and O00161 |
Pubmed |
SVM Score :0.0 |
| SNAP 23 and also syntaxin 1 and cellubrevin were found to be expressed in glial precursor cells , oligodendrocytes , and microglia . ^^^ These data suggest that the t SNAREs SNAP 23 and syntaxin 1 and the 5 SNARE cellubrevin participate in general membrane insertion mechanisms involved in diverse glial cell functions such as secretion , phagocytosis , and myelinogenesis . . ^^^ |
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| Interacting proteins: Q15836 and O00161 |
Pubmed |
SVM Score :0.0 |
| Protein kinase B stimulates the translocation of GLUT 4 but not GLUT 1 or transferrin receptors in 3T3 L 1 adipocytes by a pathway involving SNAP 23 , synaptobrevin 2 , and / or cellubrevin . ^^^ An interaction of SNAP 23 and syntaxin 4 on the plasma membrane with vesicle associated synaptobrevin 2 and / or cellubrevin , known as SNAP ( soluble N ethyl maleimide sensitive factor attachment protein ) receptors or SNAREs , has been proposed to provide the targeting and / or fusion apparatus for insulin stimulated translocation of the GLUT 4 isoform of glucose transporter to the plasma membrane . ^^^ By microinjecting 3T3 L 1 adipocytes with the Clostridium botulinum toxin B or E , which proteolyzed synaptobrevin 2 / cellubrevin and SNAP 23 , respectively , we investigated the role of these SNAREs in GLUT 4 , GLUT 1 , and transferrin receptor trafficking . ^^^ Thus , insulin appears to induce GLUT 4 translocation via two distinct routes , only one of which involves SNAP 23 and synaptobrevin 2 / cellubrevin , and can be mobilized by PKB DD . ^^^ The PKB , SNAP 23 , and synaptobrevin 2 / cellubrevin independent GLUT 4 translocation pathway may involve movement through recycling endosomes , together with GLUT 1 and transferrin receptors . . ^^^ |
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| Interacting proteins: Q15836 and O00161 |
Pubmed |
SVM Score :0.0 |
| Such analyses suggest that in 3T3 L 1 adipocytes there are approximately 374 , 000 copies of syntaxin 4 , 1 . 15 10 10 ( 6 ) copies of SNAP 23 , 495 , 000 copies of VAMP 2 , 4 . 3 10 10 ( 6 ) copies of cellubrevin and 452 , 000 copies of Munc18c per cell , compared to previous estimates of 280 , 000 copies of Glut 4 . ^^^ Thus , the main SNARE proteins involved in insulin stimulated Glut 4 exocytosis ( syntaxin 4 and VAMP 2 ) are expressed in approximately equimolar amounts in adipocytes , whereas by contrast the endosomal 5 SNARE cellubrevin is present at approximately 10 fold higher levels and the t SNARE SNAP 23 is also present in an approximately 3 fold molar excess . ^^^ |
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| Interacting proteins: Q15836 and O00161 |
Pubmed |
SVM Score :0.0 |
| Protein levels were compared with those of other molecules also implicated in organelle trafficking , including syntaxin 1 and vesicle associated membrane protein ( VAMP 2 ) and the nonneuronal analogues SNAP 23 and cellubrevin . ^^^ |
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| Interacting proteins: Q15836 and O00161 |
Pubmed |
SVM Score :0.0 |
| Subcellular distribution of 3 functional platelet SNARE proteins : human cellubrevin , SNAP 23 , and syntaxin 2 . ^^^ To evaluate this possibility , we analyzed the subcellular distribution of 3 functional platelet SNARE proteins human cellubrevin , SNAP 23 , and syntaxin 2 . ^^^ |
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| Interacting proteins: Q15836 and O00161 |
Pubmed |
SVM Score :0.0 |
| An immunoblot analysis identified the astrocyte marker glial fibrillary acidic protein , microtubule associated protein 2 , the 5 SNAREs VAMP 1 , VAMP 2 , and cellubrevin and the t SNAREs syntaxin 1 , SNAP 23 , and SNAP 25 . 3 . ^^^ |
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| Interacting proteins: Q15836 and O00161 |
Pubmed |
SVM Score :0.0 |
| We show here that ectopic expression of the plasma membrane t SNARE heavy chain syntaxin 1 in the endoplasmic reticulum induces the redistribution of its cognate vesicular SNAREs , TI VAMP and cellubrevin , and its light chain t SNARE SNAP 23 . ^^^ TI VAMP , cellubrevin and SNAP 23 associated in vivo with exogenous syntaxin 1 . ^^^ |
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| Interacting proteins: Q15836 and O00161 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15836 and O00161 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15836 and O00161 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15836 and O00161 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15836 and O00161 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15836 and O00161 |
Pubmed |
SVM Score :0.0 |
| NA |
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