| Interacting proteins: P16220 and O00141 |
Pubmed |
SVM Score :0.65932426 |
| In a cell free context , SGK physically associates with CREB and SGK phosphorylates it on serine 133 . 0.65932426^^^ |
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| Interacting proteins: P16220 and O00141 |
Pubmed |
SVM Score :0.0 |
| Prior administration of PD 98059 also antagonized the enhancing effect of 12 O tetradecanoylphorbol 13 acetate ( TPA ) , a protein kinase C activator that also causes ERK activation , on SGK phosphorylation and cAMP response element binding protein ( CREB ) phosphorylation . ^^^ |
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| Interacting proteins: P16220 and O00141 |
Pubmed |
SVM Score :0.0 |
| Components of the A kinase pathway were analyzed by Western blotting and indirect immunofluorescence using specific antibodies to the C subunit , RIIalpha / beta subunits , CREB ( cAMP regulatory element binding protein ) , phospho CREB , CBP ( CREB binding protein ) , and Sgk . ^^^ Aromatase , Sgk , and phospho CREB were expressed at elevated levels in a non forskolin responsive manner . ^^^ Most notable , both phospho CREB and Sgk were preferentially localized in a punctate pattern within the cytoplasm and not altered by forskolin . ^^^ Thus , either the mechanisms of nuclear import and export or the presence of distinct docking sites ( and functions ? ) dictate where A kinase , phospho CREB and Sgk are localized in granulosa cells compared with the terminally differentiated luteal cells . . ^^^ |
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| Interacting proteins: P16220 and O00141 |
Pubmed |
SVM Score :0.0 |
| We were unable to demonstrate a significant activation of HA SGK 1 by cAMP stimulation under conditions where we detect cAMP mediated phosphorylation of the transcription factor CREB . ^^^ |
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