| Interacting proteins: O43524 and O00141 |
Pubmed |
SVM Score :0.0 |
| Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL 1 ( FOXO3a ) . ^^^ We show here that SGK 1 , like Akt , promotes cell survival and that it does so in part by phosphorylating and inactivating FKHRL 1 . ^^^ However , SGK and Akt display differences with respect to the efficacy with which they phosphorylate the three regulatory sites on FKHRL 1 . ^^^ These findings suggest that SGK and Akt may coordinately regulate the function of FKHRL 1 by phosphorylating this transcription factor at distinct sites . ^^^ The efficient phosphorylation of these three sites on FKHRL 1 by SGK and Akt appears to be critical to the ability of growth factors to suppress FKHRL 1 dependent transcription , thereby preventing FKHRL 1 from inducing cell cycle arrest and apoptosis . ^^^ |
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| Interacting proteins: O43524 and O00141 |
Pubmed |
SVM Score :0.0 |
| Sgk is known to phosphorylate and negatively regulate pro apoptotic forkhead transcription factor FKHRL 1 . ^^^ The environmental stress stimuli that induce Sgk , but not dexamethasone , strongly inhibited the nuclear transcriptional activity and increased the cytoplasmic retention of FKHRL 1 . ^^^ |
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| Interacting proteins: O43524 and O00141 |
Pubmed |
SVM Score :0.0 |
| FKHRL 1 in response to DNA damage through protein kinase SGK 1 . ^^^ Furthermore , inhibition of SGK 1 expression by a small interfering RNA knockdown experiment significantly decreased FKHRL 1 phosphorylation in response to DNA damage . ^^^ |
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| Interacting proteins: O43524 and O00141 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we provide evidence that the Forkhead transcription factor FKHRL 1 and some of the voltage gated potassium channels are physiological substrates of sgk 1 in vivo . ^^^ |
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| Interacting proteins: O43524 and O00141 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O43524 and O00141 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O43524 and O00141 |
Pubmed |
SVM Score :0.0 |
| NA |
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